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Interleukin-1 beta

Known as: Interleukin-1beta, beta interleukin-1, Interleukin 1, Beta 
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1… 
National Institutes of Health

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Alzheimer's Disease Pathway KEGGApoptosisCell Differentiation processCell Proliferation

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Interleukin-1

Papers overview

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Highly Cited
1997
Highly Cited
1997
Constitutive intra-articular expression of human IL-1 beta following gene transfer to rabbit synovium produces all major pathologies of human rheumatoid arthritis.
To investigate the pathophysiologic effects of chronically elevated intra-articular levels of IL-1 beta, we used an ex vivo gene… 
Highly Cited
1997
Highly Cited
1997
The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis
Various pathogenic bacteria with the capacity to live within eukaryotic cells activate an apoptotic program in infected host… 
Highly Cited
1997
Highly Cited
1997
Acrolein-induced cell death in human alveolar macrophages.
Acrolein is an environmental air pollutant that is known to suppress respiratory host defense against infections. The mechanism… 
Highly Cited
1993
Highly Cited
1993
Kinetics of folding of the all-beta sheet protein interleukin-1 beta.
The folding of the all-beta sheet protein, interleukin-1 beta, was studied with nuclear magnetic resonance (NMR) spectroscopy… 
Highly Cited
1993
Highly Cited
1993
Transforming growth factor-beta and IL-1 beta act in synergy to enhance IL-6 secretion by the intestinal epithelial cell line, IEC-6.
Intestinal epithelial cells are a potentially important source for a number of cytokines that may modulate the immune response at… 
Highly Cited
1993
Highly Cited
1993
Interleukin-1 beta, -1 alpha, and -6 and prostaglandins in vaginal/cervical fluids of pregnant women before and during labor.
Interleukin-1 beta (IL-1 beta) is not detected in the amniotic fluid of normal human pregnancies before the initiation of… 
Highly Cited
1992
Highly Cited
1992
High-resolution three-dimensional structure of interleukin 1 beta in solution by three- and four-dimensional nuclear magnetic resonance spectroscopy.
The determination of the high-resolution three-dimensional solution structure of interleukin 1 beta (IL-1 beta), a protein of 153… 
Highly Cited
1991
Highly Cited
1991
Cytokine-mediated regulation of human leukocyte gelatinases and role in arthritis.
Gelatinases (type IV collagenases) produced by normal peripheral blood leukocytes were studied by the use of a substrate… 
Highly Cited
1991
Highly Cited
1991
Interleukin‐6 messenger RNA expression and interleukin‐6 protein secretion in cells isolated from normal human bone: Regulation by interleukin‐1
Recent evidence suggests that cytokines, in addition to regulating hematopoiesis and immune functions, may be important paracrine… 
Highly Cited
1990
Highly Cited
1990
Cytokine regulation of IL-1 beta gene expression in the human polymorphonuclear leukocyte.
Although recently polymorphonuclear leukocytes (PMN) have been identified as producers of IL-1 beta in response to LPS and… 
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