Interleukin 1 Receptor Antagonist Protein

Known as: Interleukin 1 Inhibitor, Urine, IL1 Inhibitor, Urine-Derived, Urine-Derived IL1 Inhibitor 
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER… (More)
National Institutes of Health

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23 relations

Broader (1)

Antirheumatic Agents

Narrower (7)

AntrilIL-1ra-Fc-IL-18bp fusion proteinIL1RN protein, humanINTERLEUKIN 1 RECEPTOR ANTAGONIST DEFICIENCY
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IL1RN geneIL1RN wt AlleleIn BloodInterleukin 1 Receptor Antagonist Measurement
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Papers overview

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Review
2010
Review
2010
Interleukin-1 (IL-1) pathway.
The interleukin-1 (IL-1) family of cytokines comprises 11 proteins (IL-1F1 to IL-1F11) encoded by 11 distinct genes in humans and… (More)
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Highly Cited
2005
Highly Cited
2005
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines.
Cytokines of the interleukin-1 (IL-1) family, such as IL-1 alpha/beta and IL-18, have important functions in host defense, immune… (More)
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Highly Cited
2000
Highly Cited
2000
Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice
Interleukin (IL)-1 is a proinflammatory cytokine that plays important roles in inflammation, host defense, and the neuro-immuno… (More)
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Highly Cited
2000
Highly Cited
2000
High altitude increases circulating interleukin-6, interleukin-1 receptor antagonist and C-reactive protein.
Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the development of high-altitude pulmonary… (More)
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Review
1998
Review
1998
Interleukin-1 receptor antagonist: role in biology.
The interleukin-1 receptor antagonist (IL-1Ra) is a member of the IL-1 family that binds to IL-1 receptors but does not induce… (More)
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Review
1998
Review
1998
Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist.
IL-1 (IL-1 alpha or IL-1 beta) is the prototypic "multifunctional" cytokine. Unlike the lymphocyte and colony stimulating growth… (More)
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Highly Cited
1998
Highly Cited
1998
Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist.
OBJECTIVE To evaluate the efficacy and safety of interleukin-1 receptor antagonist (IL-1Ra) in patients with rheumatoid arthritis… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin-6 and interleukin-1 receptor antagonist in acute stroke.
Elevated plasma levels of interleukin-6 (IL-6), a key regulator of the acute phase response that includes increased fibrinogen… (More)
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Review
1993
Review
1993
Interleukin-1 receptor antagonist.
IL-1ra is the first described naturally occurring receptor antagonist of any cytokine or hormone-like molecule. IL-1ra is a… (More)
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Highly Cited
1990
Highly Cited
1990
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
Human monocytes induced with adherent IgG secrete an interleukin-1 receptor antagonist which could be important for the in vivo… (More)
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