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IL1RN gene

Known as: IL-1RN, INTERLEUKIN 1 RECEPTOR ANTAGONIST, MGC10430 
This gene is involved in the inhibition of signaling.
National Institutes of Health

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Cytokine Receptor BindingCytokine SignalingIL1R1 geneIL1R1 wt Allele

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IL1RN wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
Genetic and immunological markers predict titanium implant failure: a retrospective study.
Highly Cited
2006
Highly Cited
2006
Most of the interleukin 1 receptor antagonist, cathepsin S, macrophage migration inhibitory factor, nerve growth factor, and interleukin 18 release by explants of human adipose tissue is by the non…
Highly Cited
2005
Highly Cited
2005
Interleukin 1B gene (IL-1B) and interleukin 1 receptor antagonist gene (IL-1RN) polymorphisms in Helicobacter pylori-negative gastric cancer of intestinal and diffuse histotype.
BACKGROUND Polymorphisms in the interleukin 1beta gene (IL-1B-31T/C and IL-1B-511C/T single nucleotide changes) and in the… 
Highly Cited
2001
Highly Cited
2001
A polymorphism within the interleukin 1 receptor antagonist (IL-1Ra) gene is associated with ankylosing spondylitis.
OBJECTIVE Genetic factors that predispose individuals to ankylosing spondylitis (AS) are not fully understood, but are unlikely… 
Highly Cited
2000
Highly Cited
2000
Arterial Inflammation in Mice Lacking the Interleukin 1 Receptor Antagonist Gene
Branch points and flexures in the high pressure arterial system have long been recognized as sites of unusually high turbulence… 
Highly Cited
2000
Highly Cited
2000
Genetic factors determine extent of bone loss in inflammatory bowel disease.
BACKGROUND & AIMS Although bone loss and osteoporosis are well-known long-term sequelae of inflammatory bowel disease (IBD), the… 
Highly Cited
1999
Highly Cited
1999
Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro.
The beta-cells in the pancreatic islets of Langerhans are the targets of autoreactive T-cells and are destroyed in type 1… 
Highly Cited
1994
Highly Cited
1994
Interleukin 1 receptor antagonist gene polymorphism association with lichen sclerosus
Cytokines play key roles in immune responses, inflammation and fibrosis. The balance between levels of cytokines, their receptors… 
Highly Cited
1994
Highly Cited
1994
Suppression of intra-articular responses to interleukin-1 by transfer of the interleukin-1 receptor antagonist gene to synovium.
We have developed an ex vivo method for delivering genes to the synovial lining of joints and expressing them intra-articularly… 
Highly Cited
1993
Highly Cited
1993
The effect of an interleukin-1 receptor antagonist protein on type II collagen-induced arthritis and antigen-induced arthritis in mice.
OBJECTIVE To investigate the anti-arthritic effect of recombinant human interleukin-1 receptor antagonist protein (IRAP) in two… 
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