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IL1R1 wt Allele

Known as: IL1R, D2S1473, P80 
Human IL1R1 wild-type allele is located within 2q12 and is approximately 26 kb in length. This allele, which encodes interleukin-1 receptor type 1… 
National Institutes of Health

Related topics

Related topics

11 relations
2q12ApoptosisCytokine Signaling ProcessIL1R Signaling Pathway

Broader (1)

IL1R1 gene

Papers overview

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Highly Cited
2019
Highly Cited
2019
Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome
We recently reported successful treatment of a child with febrile infection‐related epilepsy syndrome (FIRES), a subtype of new… 
2017
2017
Katanin p80, NuMA and cytoplasmic dynein cooperate to control microtubule dynamics
Human mutations in KATNB1 (p80) cause severe congenital cortical malformations, which encompass the clinical features of both… 
Review
2013
Review
2013
How biologics targeting the IL‐1 system are being considered for the treatment of type 2 diabetes
Metabolic diseases are associated with activation of the innate immune system in various tissues and characterized by elevated… 
2012
2012
Footprints of genetic susceptibility to pulmonary tuberculosis: Cytokine gene variants in north Indians
Background & objectives: Tuberculosis is (TB) responsible for high morbidity and mortality worldwide. Cytokines play a major role… 
Highly Cited
2011
Highly Cited
2011
Hormonal and Inflammatory Responses to Different Types of Sprint Interval Training
Meckel, Y, Nemet, D, Bar-Sela, S, Radom-Aizik, S, Cooper, DM, Sagiv, M, and Eliakim, A. Hormonal and inflammatory responses to… 
2004
2004
IL1β and TNFα differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: evidence of changes associated to cell maturation
Highly Cited
2003
Highly Cited
2003
Leptin modulates inflammatory cytokine and neuroendocrine responses to endotoxin in the primate.
Leptin, which plays a crucial role in regulating energy balance, can also modulate the inflammatory response. Although leptin… 
2002
2002
Anti‐D (WinRho SD™) treatment of children with chronic autoimmune thrombocytopenic purpura stimulates transient cytokine/chemokine production
Intravenous anti‐D is often used in the treatment of autoimmune thrombocytopenic purpura (AITP), but little is known about its… 
Highly Cited
2000
Highly Cited
2000
Arguments for interleukin 1 as a target in chronic arthritis.
Tumour necrosis factor (TNF) and interleukin 1 (IL1) are considered as master cytokines in chronic, destructive arthritis… 
Highly Cited
1994
Highly Cited
1994
Intratracheal administration of endotoxin and cytokines. VII. The soluble interleukin-1 receptor and the soluble tumor necrosis factor receptor II (p80) inhibit acute inflammation.
Intratracheal administration of endotoxin (LPS) causes acute neutrophilic inflammation via induction of pulmonary tumor necrosis… 
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