Integrase

Known as: Integrases, Integrases [Chemical/Ingredient] 
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
010020019762017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Human immunodeficiency virus type-1 (HIV-1) integrase is one of the three virally encoded enzymes required for replication and… (More)
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Highly Cited
2007
Highly Cited
2007
Germ-line transformation via transposable elements is a powerful tool to study gene function in Drosophila melanogaster. However… (More)
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Highly Cited
2004
Highly Cited
2004
The phiC31 integrase functions efficiently in vitro and in Escherichia coli, yeast, and mammalian cells, mediating unidirectional… (More)
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Highly Cited
2001
Highly Cited
2001
We previously established that the phage phiC31 integrase, a site-specific recombinase, mediates efficient integration in the… (More)
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Highly Cited
2001
Highly Cited
2001
Retroviral integrase, an essential enzyme for replication of human immunodeficiency virus type-1 (HIV-1) and other retroviruses… (More)
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Highly Cited
2000
Highly Cited
2000
The integrase from the Streptomyces phage phiC31 carries out efficient recombination between the attP site in the phage genome… (More)
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Highly Cited
1997
Highly Cited
1997
The karyophilic properties of the HIV-1 nucleoprotein complex facilitate infection of nondividing cells such as macrophages and… (More)
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Highly Cited
1995
Highly Cited
1995
The integration of a DNA copy of the human immunodeficiency virus type 1 (HIV-1) genome into a chromosome of an infected cell is… (More)
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Highly Cited
1994
Highly Cited
1994
HIV integrase is the enzyme responsible for inserting the viral DNA into the host chromosome; it is essential for HIV replication… (More)
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Highly Cited
1994
Highly Cited
1994
Upon entry into a host cell, retroviruses direct the reverse transcription of the viral RNA genome and the establishment of an… (More)
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