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Integrase

Known as: Integrases, Integrases [Chemical/Ingredient] 
Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate… 
National Institutes of Health

Related topics

Related topics

21 relations
Anti-HIV AgentsGenes, ViralHIV IntegraseIn Blood

Narrower (5)

Cre recombinaseInTI2 protein, E coliXerC protein, E coliXerD protein, E coli

Broader (2)

DNA NucleotidyltransferasesViral Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Dolutegravir monotherapy in HIV-infected naive patients with an HIV-RNA load <100 000 copies/mL: a medium-term follow-up
linezolid before introduction of tedizolid. Interestingly, in two cases, though we immediately introduced tedizolid after… 
2008
2008
HIV-1 Integrase Strand Transfer Inhibitors: Novel Insights into their Mechanism of Action.
Human immunodefi ciency virus type-1 integrase (IN) is a new and novel target for inhibitors. Strand transfer inhibitors… 
Highly Cited
2007
Highly Cited
2007
Transcriptional Coactivator LEDGF/p75 Modulates Human Immunodeficiency Virus Type 1 Integrase-Mediated Concerted Integration
ABSTRACT Human transcriptional coactivator p75/lens epithelium-derived growth factor (LEDGF) binds human immunodeficiency virus… 
2003
2003
Mutations in the C-terminal domain of ALSV (Avian Leukemia and Sarcoma Viruses) integrase alter the concerted DNA integration process in vitro.
Integrase (IN) is the retroviral enzyme responsible for the integration of the DNA copy of the retroviral genome into the host… 
Review
2002
Review
2002
Structure-based inhibitor design targeting HIV-1 integrase.
HIV integrase (IN) is a viral-encoded protein that catalyzes the breaking and joining reactions that mediate integration of viral… 
Review
2002
Review
2002
Novel aryl diketo-containing inhibitors of HIV-1 integrase
HIV-1 integrase is a promising therapeutic target for the development of drugs to treat HIV infection. Aryl diketo-based analogs… 
2002
2002
Mapping the Epitope of an Inhibitory Monoclonal Antibody to the C-terminal DNA-binding Domain of HIV-1 Integrase*
Integrase (IN) catalyzes the insertion of retroviral DNA into chromosomal DNA of a host cell and is one of three virus-encoded… 
2002
2002
Analysis of conserved and non-conserved amino acids critical for ALSV (Avian leukemia and sarcoma viruses) integrase functions in vitro
Summary. Retroviral integrase (IN) is the viral enzyme responsible for the integration of viral DNA into host cellular DNA. In… 
1999
1999
An active foamy virus integrase is required for virus replication.
Foamy viruses (FVs) make use of a replication strategy which is unique among retroviruses and shows analogies to hepadnaviruses… 
1995
1995
Substrate specificity of Ty1 integrase
Integration of the Saccharomyces cerevisiae retrotransposon Ty1 requires the element-encoded integrase (IN) protein, which is a… 
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