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HIV Integrase
Known as:
HIV Integration Protein
, Integration Protein, HIV
, HIV Integrase [Chemical/Ingredient]
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Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is…
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National Institutes of Health
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Related topics
Related topics
9 relations
Broader (1)
DNA Nucleotidyltransferases
In Blood
Integrase
Process of secretion
aspects of radiation effects
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Narrower (1)
p31 integrase protein, Human immunodeficiency virus 1
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
Hajar Sirous
,
Giulia Chemi
,
+8 authors
M. Brindisi
Frontiers in Chemistry
2019
Corpus ID: 201119412
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy…
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2019
2019
RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration.
Kylie Standage-Beier
,
Nicholas Brookhouser
,
Parithi Balachandran
,
Qi Zhang
,
D. Brafman
,
Xiao Wang
The CRISPR Journal
2019
Corpus ID: 201274990
CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on…
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Highly Cited
2016
Highly Cited
2016
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.
J. Hultquist
,
Kathrin Schumann
,
+6 authors
A. Marson
Cell Reports
2016
Corpus ID: 21657331
Highly Cited
2012
Highly Cited
2012
Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization
F. Christ
,
Stephen M. Shaw
,
+8 authors
C. Pickford
Antimicrobial Agents and Chemotherapy
2012
Corpus ID: 12214310
ABSTRACT Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel anti-HIV therapies. We have…
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Highly Cited
2012
Highly Cited
2012
Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
T. Peat
,
D. Rhodes
,
+13 authors
J. Deadman
PLoS ONE
2012
Corpus ID: 6462043
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to…
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Highly Cited
2010
Highly Cited
2010
The mechanism of retroviral integration through X-ray structures of its key intermediates
G. Maertens
,
S. Hare
,
P. Cherepanov
Nature
2010
Corpus ID: 2597876
To establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA. This…
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Highly Cited
2008
Highly Cited
2008
Screening for Antiviral Inhibitors of the HIV Integrase—LEDGF/p75 Interaction Using the AlphaScreen™ Luminescent Proximity Assay
Yan Hou
,
Debra Mcguinness
,
+5 authors
J. Howe
Journal of biomolecular screening
2008
Corpus ID: 30073190
Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV…
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2008
2008
The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
D. Langley
,
H. Samanta
,
Zeyu Lin
,
M. A. Walker
,
M. Krystal
,
I. Dicker
Biochemistry
2008
Corpus ID: 25804729
Specific HIV integrase strand transfer inhibitors are thought to bind to the integrase active site, positioned to coordinate with…
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Highly Cited
2007
Highly Cited
2007
3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase.
T. Kawasuji
,
M. Fuji
,
T. Yoshinaga
,
A. Sato
,
T. Fujiwara
,
R. Kiyama
Bioorganic & Medicinal Chemistry
2007
Corpus ID: 29516375
Highly Cited
2006
Highly Cited
2006
A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
T. Kawasuji
,
M. Fuji
,
T. Yoshinaga
,
A. Sato
,
T. Fujiwara
,
R. Kiyama
Bioorganic & Medicinal Chemistry
2006
Corpus ID: 19791049
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