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HIV Integrase

Known as: HIV Integration Protein, Integration Protein, HIV, HIV Integrase [Chemical/Ingredient] 
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is… Expand
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
New genetic tools are needed to understand the functional interactions between HIV and human host factors in primary cells. We… Expand
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Highly Cited
2012
Highly Cited
2012
Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel anti-HIV therapies. We have… Expand
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2012
2012
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to… Expand
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2011
2011
Identification of cytotoxic T lymphocyte (CTL) epitopes from tumor antigens is essential for the development of peptide vaccines… Expand
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Highly Cited
2010
Highly Cited
2010
To establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA. This… Expand
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2008
2008
Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV… Expand
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2008
2008
Specific HIV integrase strand transfer inhibitors are thought to bind to the integrase active site, positioned to coordinate with… Expand
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2007
2007
The HIV integrase enzyme (IN) catalyzes the initial DNA breaking and joining reactions that integrate viral DNA in the host… Expand
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2007
2007
The two-metal binding model we previously reported as an inhibition mechanism of HIV integrase (HIV IN) produced a new direction… Expand
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2006
2006
We propose a two-metal binding model as a potential mechanism of chelating inhibitors against HIV integrase (HIV IN) represented… Expand
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