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HIV Integrase

Known as: HIV Integration Protein, Integration Protein, HIV, HIV Integrase [Chemical/Ingredient] 
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is… 
National Institutes of Health

Papers overview

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2019
2019
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy… 
2019
2019
CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on… 
Highly Cited
2012
Highly Cited
2012
ABSTRACT Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel anti-HIV therapies. We have… 
Highly Cited
2012
Highly Cited
2012
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to… 
Highly Cited
2010
Highly Cited
2010
To establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA. This… 
Highly Cited
2008
Highly Cited
2008
Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV… 
2008
2008
Specific HIV integrase strand transfer inhibitors are thought to bind to the integrase active site, positioned to coordinate with… 
Highly Cited
2007