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HIV Integrase

Known as: HIV Integration Protein, Integration Protein, HIV, HIV Integrase [Chemical/Ingredient] 
Enzyme of the HUMAN IMMUNODEFICIENCY VIRUS that is required to integrate viral DNA into cellular DNA in the nucleus of a host cell. HIV integrase is… 
National Institutes of Health

Related topics

Related topics

9 relations

Broader (1)

DNA Nucleotidyltransferases
In BloodIntegraseProcess of secretionaspects of radiation effects

Narrower (1)

p31 integrase protein, Human immunodeficiency virus 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Identification of Novel 3-Hydroxy-pyran-4-One Derivatives as Potent HIV-1 Integrase Inhibitors Using in silico Structure-Based Combinatorial Library Design Approach
We describe herein the development and experimental validation of a computational protocol for optimizing a series of 3-hydroxy… 
2019
2019
RNA-Guided Recombinase-Cas9 Fusion Targets Genomic DNA Deletion and Integration.
CRISPR-based technologies have become central to genome engineering. However, CRISPR-based editing strategies are dependent on… 
Highly Cited
2016
Highly Cited
2016
A Cas9 Ribonucleoprotein Platform for Functional Genetic Studies of HIV-Host Interactions in Primary Human T Cells.
Highly Cited
2012
Highly Cited
2012
Small-Molecule Inhibitors of the LEDGF/p75 Binding Site of Integrase Block HIV Replication and Modulate Integrase Multimerization
ABSTRACT Targeting the HIV integrase (HIV IN) is a clinically validated approach for designing novel anti-HIV therapies. We have… 
Highly Cited
2012
Highly Cited
2012
Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design
A fragment-based screen against human immunodeficiency virus type 1 (HIV) integrase led to a number of compounds that bound to… 
Highly Cited
2010
Highly Cited
2010
The mechanism of retroviral integration through X-ray structures of its key intermediates
To establish productive infection, a retrovirus must insert a DNA replica of its genome into host cell chromosomal DNA. This… 
Highly Cited
2008
Highly Cited
2008
Screening for Antiviral Inhibitors of the HIV Integrase—LEDGF/p75 Interaction Using the AlphaScreen™ Luminescent Proximity Assay
Small-molecule inhibitors of HIV integrase (HIV IN) have emerged as a promising new class of antivirals for the treatment of HIV… 
2008
2008
The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
Specific HIV integrase strand transfer inhibitors are thought to bind to the integrase active site, positioned to coordinate with… 
Highly Cited
2007
Highly Cited
2007
3-Hydroxy-1,5-dihydro-pyrrol-2-one derivatives as advanced inhibitors of HIV integrase.
Highly Cited
2006
Highly Cited
2006
A platform for designing HIV integrase inhibitors. Part 2: a two-metal binding model as a potential mechanism of HIV integrase inhibitors.
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