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Genome-wide analysis of estrogen receptor binding sites
All estrogen receptor and RNA polymerase II binding sites are mapped on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells, and distinct temporal mechanisms of estrogen-mediated gene regulation are demonstrated.
Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1
Genome-Wide Localization of the Nuclear Transport Machinery Couples Transcriptional Status and Nuclear Organization
Mutants Affecting the Structure of the Cortical Endoplasmic Reticulum in Saccharomyces cerevisiae
- W. Prinz, L. Grzyb, M. Veenhuis, J. Kahana, P. Silver, T. Rapoport
- BiologyThe Journal of cell biology
- 7 August 2000
It is demonstrated that, both in wild-type and mutant cells, the ER and mitochondria partially coalign, and that mutations that disrupt ER structure also affect mitochondrial structure, suggesting that proper ER structure may be required to maintain mitochondrial structure.
HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection.
The data suggest Vpr functionally resembles importin-beta in nuclear import of the HIV-1 pre-integration complex and this function is essential for the role of Vpr in macrophage infection, but not G2 arrest.
Toehold Switches: De-Novo-Designed Regulators of Gene Expression
Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin β homologs NMD5 and XPO1
These findings define the requirements for the regulated nuclear transport of a stress‐activated MAP kinase.
Elimination of replication block protein Fob1 extends the life span of yeast mother cells.
Spatially Ordered Dynamics of the Bacterial Carbon Fixation Machinery
It is shown that carboxysomes are linearly arranged within the cytoplasm in a process that involves the bacterial cytoskeleton, an organelle-like proteinaceous microcompartment that sequesters the enzymes of carbon fixation from the cy toplasm.