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Insulin-Like Growth Factor Binding Protein 4
Known as:
Insulin Like Growth Factor Binding Protein 4
, IGFBP-4
, IGF Binding Protein 4
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One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at…
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National Institutes of Health
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Related topics
Related topics
11 relations
IGFBP4 gene
IGFBP4 wt Allele
In Blood
Process of secretion
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Insulin-Like Growth Factor-Binding Protein 4, human
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5.
L. Laursen
,
Kasper Kjaer-Sorensen
,
M. H. Andersen
,
C. Oxvig
Molecular Endocrinology
2007
Corpus ID: 28123938
The biological activity of IGF-I and -II is controlled by six binding proteins (IGFBPs), preventing the IGFs from interacting…
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Review
2004
Review
2004
Insulin-Like Growth Factor-1 as a Vascular Protective Factor
E. Conti
,
C. Carrozza
,
+4 authors
F. Andreotti
Circulation
2004
Corpus ID: 11526588
Recent advances in cardiology have focused on proliferation and regeneration as potential cardiovascular defense mechanisms…
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Highly Cited
2002
Highly Cited
2002
Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the…
L. Giudice
,
C. Conover
,
+9 authors
C. Oxvig
Journal of Clinical Endocrinology and Metabolism
2002
Corpus ID: 1013160
The IGF family plays an important role in implantation and placental physiology. IGF-II is abundantly expressed by placental…
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Highly Cited
2001
Highly Cited
2001
Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.
S. Réhault
,
P. Monget
,
+4 authors
T. Moreau
European Journal of Biochemistry
2001
Corpus ID: 21434677
Insulin-like growth factors (IGFs) are important growth regulators of both normal and malignant prostate cells. Their action is…
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Highly Cited
2001
Highly Cited
2001
Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A
L. Laursen
,
M. Overgaard
,
+5 authors
C. Oxvig
FEBS Letters
2001
Corpus ID: 6468895
Highly Cited
1994
Highly Cited
1994
Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells.
R. Okazaki
,
B. Riggs
,
C. Conover
Endocrinology
1994
Corpus ID: 32497891
Glucocorticoid (GC) modulates insulin-like growth factor (IGF) action in bone through mechanisms that are complex and not well…
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Highly Cited
1994
Highly Cited
1994
Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.
S. Kanzaki
,
S. Hilliker
,
D. Baylink
,
S. Mohan
Endocrinology
1994
Corpus ID: 24261389
Previous studies have shown that the actions of insulin-like growth factor-II (IGF-II) in bone are determined by both its…
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Highly Cited
1994
Highly Cited
1994
Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth…
T. McCarthy
,
S. Casinghino
,
M. Centrella
,
E. Canalis
Journal of Cellular Physiology
1994
Corpus ID: 6161049
Primary osteoblast‐enriched (Ob) cultures from fetal rat bone synthesize insulinlike growth factor (IGF) I and IGF‐II, which each…
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Highly Cited
1993
Highly Cited
1993
Vascular smooth muscle cells synthesize two forms of insulin‐like growth factor binding proteins which are regulated differently by the insulin‐like growth factors
W. Cohick
,
A. Gockerman
,
D. Clemmons
Journal of Cellular Physiology
1993
Corpus ID: 7282628
Vascular smooth muscle cells (SMC) synthesize insulin‐like growth factor‐I (IGF‐I), which is a mitogen for this cell type in…
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Highly Cited
1992
Highly Cited
1992
Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.
C. Camacho‐Hubner
,
W. Busby
,
R. McCusker
,
G. Wright
,
D. Clemmons
Journal of Biological Chemistry
1992
Corpus ID: 6647202
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