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Insulin-Like Growth Factor Binding Protein 4

Known as: Insulin Like Growth Factor Binding Protein 4, IGFBP-4, IGF Binding Protein 4 
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at… 
National Institutes of Health

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IGFBP4 geneIGFBP4 wt AlleleIn BloodProcess of secretion

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Insulin-Like Growth Factor-Binding Protein 4, human

Papers overview

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Review
2003
Review
2003
IGF-binding protein-4: biochemical characteristics and functional consequences.
IGFs have multiple functions regarding cellular growth, survival and differentiation under different physiological and… 
1997
1997
Effect of celiac disease and gluten-free diet on growth hormone-binding protein, insulin-like growth factor-I, and insulin-like growth factor-binding proteins.
Failure to thrive is common in children with celiac disease. As alterations in the growth hormone-insulin-like growth factor I… 
Highly Cited
1996
Highly Cited
1996
Insulin-like growth factor-binding proteins produced by Vero cells, human oviductal cells and human endometrial cells, and the role of insulin-like growth factor-binding protein-3 in mouse embryo co…
Co-culturing embryos on helper cells can mimic the in-vivo environment, thereby enhancing embryo development in vitro. Insulin… 
Highly Cited
1996
Highly Cited
1996
Insulin-like growth factors stimulate the release of insulin-like growth factor-binding protein-3 (IGFBP-3) and degradation of IGFBP-4 in nonsmall cell lung cancer cell lines.
Insulin-like growth factors (IGFs) are potent mitogens for lung cancer cells. Their proliferative activity is influenced by their… 
1996
1996
Physiological role of insulin-like-growth-factor-binding protein-4 in human folliculogenesis.
Insulin-like growth factor (IGF)-I and IGF-II, and their binding proteins (IGFBPs) have been demonstrated to play important roles… 
Highly Cited
1996
Highly Cited
1996
Nutritional regulation of gene expression of insulin-like growth factor-binding proteins and the acid-labile subunit in various tissues of rats.
The plasma concentration and liver mRNA content of IGF-I are regulated by the quantity and quality of dietary proteins. To… 
Highly Cited
1995
Highly Cited
1995
IGF binding proteins-4, -5 and -6 may play specialized roles during L6 myoblast proliferation and differentiation.
It is well known that IGFs-I and -II stimulate both the proliferation and differentiation of myoblasts, but the role of the IGF… 
Highly Cited
1994
Highly Cited
1994
Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth…
Primary osteoblast‐enriched (Ob) cultures from fetal rat bone synthesize insulinlike growth factor (IGF) I and IGF‐II, which each… 
Highly Cited
1994
Highly Cited
1994
Expression of insulin‐like growth factor binding protein‐4 and ‐5 mRNAs in adult rat forebrain
Accumulating evidence indicates that the insulin‐like growth factors (IGFs) can act as neurotrophic factors. A family of at least… 
Highly Cited
1993
Highly Cited
1993
Insulin-like growth factors (IGFs) block FSH-induced proteolysis of IGF-binding protein-5 (BP-5) in cultured rat granulosa cells.
Rat granulosa cells (GC), in vitro, express IGFBPs under the influence of both FSH and IGF-I. The major IGFBP produced by GC is a… 
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