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Insulin-Like Growth Factor Binding Protein 4

Known as: Insulin Like Growth Factor Binding Protein 4, IGFBP-4, IGF Binding Protein 4 
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at… Expand
National Institutes of Health

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IGFBP4 geneIGFBP4 wt AlleleIn BloodProcess of secretion
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Insulin-Like Growth Factor-Binding Protein 4, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5.
The biological activity of IGF-I and -II is controlled by six binding proteins (IGFBPs), preventing the IGFs from interacting… Expand
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2003
2003
Serum levels of insulin-like growth factor (IGF)-I and IGF binding protein (IGFBP)-1 to -6 and their relationship to bone metabolism in osteoporosis patients.
BACKGROUND: Insulin-like growth factor (IGF) system components are important regulators of bone formation. Alterations of… Expand
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Highly Cited
2002
Highly Cited
2002
Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the…
The IGF family plays an important role in implantation and placental physiology. IGF-II is abundantly expressed by placental… Expand
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Highly Cited
2001
Highly Cited
2001
Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.
Insulin-like growth factors (IGFs) are important growth regulators of both normal and malignant prostate cells. Their action is… Expand
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Highly Cited
2001
Highly Cited
2001
Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A
Pregnancy‐associated plasma protein‐A (PAPP‐A) has recently been identified as the proteinase responsible for cleavage of insulin… Expand
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Highly Cited
2001
Highly Cited
2001
Evidence that IGF-binding protein-5 functions as a growth factor.
Recent studies support the concept that IGF-binding protein-5 (IGFBP-5) stimulates bone formation, at least in part, via IGF… Expand
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Highly Cited
1998
Highly Cited
1998
Regulation of insulin-like growth factors I and II and their binding proteins in human bone marrow stromal cells by dexamethasone.
Glucocorticoids inhibit the proliferation, but induce the differentiation, of bone marrow stromal cells into osteoblast-like… Expand
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Highly Cited
1994
Highly Cited
1994
Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.
Previous studies have shown that the actions of insulin-like growth factor-II (IGF-II) in bone are determined by both its… Expand
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Highly Cited
1994
Highly Cited
1994
Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells.
Glucocorticoid (GC) modulates insulin-like growth factor (IGF) action in bone through mechanisms that are complex and not well… Expand
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Highly Cited
1994
Highly Cited
1994
Complex pattern of insulin-like growth factor binding protein expression in primary rat osteoblast enriched cultures: regulation by prostaglandin E2, growth hormone, and the insulin-like growth…
Primary osteoblast-enriched (Ob) cultures from fetal rat bone synthesize insulin-like growth factor (IGF) I and IGF-II, which… Expand
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