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Insulin-Like Growth Factor Binding Protein 4

Known as: Insulin Like Growth Factor Binding Protein 4, IGFBP-4, IGF Binding Protein 4 
One of the six homologous soluble proteins that bind insulin-like growth factors (SOMATOMEDINS) and modulate their mitogenic and metabolic actions at… 
National Institutes of Health

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IGFBP4 geneIGFBP4 wt AlleleIn BloodProcess of secretion
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Insulin-Like Growth Factor-Binding Protein 4, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
Regulation of insulin-like growth factor (IGF) bioactivity by sequential proteolytic cleavage of IGF binding protein-4 and -5.
The biological activity of IGF-I and -II is controlled by six binding proteins (IGFBPs), preventing the IGFs from interacting… 
Review
2004
Review
2004
Insulin-Like Growth Factor-1 as a Vascular Protective Factor
Recent advances in cardiology have focused on proliferation and regeneration as potential cardiovascular defense mechanisms… 
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Review
2004
Review
2004
The multi-functional role of insulin-like growth factor binding proteins in bone
The insulin-like growth factor (IGF) system is an important regulator of bone formation. The IGFs (IGF-I and IGF-II) are the most… 
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Review
2004
Review
2004
Proteolytic Degradation of Insulin-Like Growth Factor Binding Proteins by Ovarian Follicles: A Control Mechanism for Selection of Dominant Follicles1
  • L. Spicer
  • Biology of reproduction
  • 2004
  • Corpus ID: 24104448
Abstract This review summarizes evidence for the role of proteolytic enzymes that degrade and inactivate insulin-like growth… 
Highly Cited
2001
Highly Cited
2001
Insulin-like growth factor binding proteins (IGFBPs) as potential physiological substrates for human kallikreins hK2 and hK3.
Insulin-like growth factors (IGFs) are important growth regulators of both normal and malignant prostate cells. Their action is… 
Highly Cited
2001
Highly Cited
2001
Pregnancy‐associated plasma protein‐A (PAPP‐A) cleaves insulin‐like growth factor binding protein (IGFBP)‐5 independent of IGF: implications for the mechanism of IGFBP‐4 proteolysis by PAPP‐A
Pregnancy‐associated plasma protein‐A (PAPP‐A) has recently been identified as the proteinase responsible for cleavage of insulin… 
Highly Cited
1994
Highly Cited
1994
Evidence that human bone cells in culture produce insulin-like growth factor-binding protein-4 and -5 proteases.
Previous studies have shown that the actions of insulin-like growth factor-II (IGF-II) in bone are determined by both its… 
Highly Cited
1994
Highly Cited
1994
Glucocorticoid regulation of insulin-like growth factor-binding protein expression in normal human osteoblast-like cells.
Glucocorticoid (GC) modulates insulin-like growth factor (IGF) action in bone through mechanisms that are complex and not well… 
Highly Cited
1994
Highly Cited
1994
Complex pattern of insulin‐like growth factor binding protein expression in primary rat osteoblast enriched cultures: Regulation by prostaglandin E2, growth hormone, and the insulin‐like growth…
Primary osteoblast‐enriched (Ob) cultures from fetal rat bone synthesize insulinlike growth factor (IGF) I and IGF‐II, which each… 
Highly Cited
1992
Highly Cited
1992
Identification of the forms of insulin-like growth factor-binding proteins produced by human fibroblasts and the mechanisms that regulate their secretion.
Human fibroblasts secrete insulin-like growth factor-binding proteins (IGFBPs) that can modify insulin-like growth factor (IGF) I… 
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