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Inositol 1,4,5-Trisphosphate

Known as: 1,4,5-IP3, INs-P3, Myo-Inositol 1,4,5-Trisphosphate 
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (3)

6-deoxyinositol 1,4,5-triphosphateinositol 1,4,5-triphosphorothioateinositol 1,4,6-trisphosphate
Calcium SignalingIn BloodProcess of secretionagonists

Broader (4)

Inositol PhosphatesSecond Messenger Systemsinositol triphosphatesecond messenger

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
Ca2+ entry into PC12 cells initiated by ryanodine receptors or inositol 1,4,5-trisphosphate receptors.
Capacitative Ca2+ entry (CCE) is a universal mechanism for refilling intracellular Ca2+ stores in electrically non-excitable… 
Highly Cited
1993
Highly Cited
1993
Inositol 1,4,5-trisphosphate mass changes from fertilization through first cleavage in Xenopus laevis.
After fertilization in Xenopus laevis, inositol 1,4,5-trisphosphate (IP3) mass increased from 53 to 261 fmol/cell and returned to… 
Highly Cited
1992
Highly Cited
1992
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Highly Cited
1990
Highly Cited
1990
The size of inositol 1,4,5-trisphosphate-sensitive Ca2+ stores depends on inositol 1,4,5-trisphosphate concentration.
An explanation of the complex effects of hormones on intracellular Ca2+ requires that the intracellular actions of Ins(1,4,5)P3… 
Highly Cited
1988
Highly Cited
1988
Cyclic Guanosine Monophosphate‐Enhanced Sequestration of Ca2+ by Sarcoplasmic Reticulum in Vascular Smooth Muscle
The purpose of this study was to investigate the effects of the intracellular messenger cyclic GMP (cGMP) on sequestration of… 
Highly Cited
1988
Highly Cited
1988
Inositol 1,4,5‐trisphosphate and diacylglycerol mimic bradykinin effects on mouse neuroblastoma x rat glioma hybrid cells.
1. The role of inositol 1,4,5‐trisphosphate (InsP3) and diacylglycerol (DAG) as possible mediators of the membrane current… 
Highly Cited
1986
Highly Cited
1986
Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein
To investigate the roles of inositol 1,4,5-trisphosphate (InsP3) and guanyl nucleotide binding proteins (G-proteins) in the… 
Highly Cited
1986
Highly Cited
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
Highly Cited
1985
Highly Cited
1985
Inositol 1,4,5-trisphosphate-induced release of sequestered Ca2+ from highly purified human platelet intracellular membranes.
Evidence has accumulated in support of a role for intracellularly generated inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] in… 
Highly Cited
1981
Highly Cited
1981
The polyphosphoinositide phosphodiesterase of erythrocyte membranes.
1. A new assay procedure has been devised for measurement of the Ca(2+)-activated polyphosphoinositide phosphodiesterase… 
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