FAQ

Inositol 1,4,5-Trisphosphate

Known as: 1,4,5-IP3, INs-P3, Myo-Inositol 1,4,5-Trisphosphate 
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1959-2017
020040019592017

Related topics

Related topics

17 relations
Calcium SignalingIn BloodProcess of secretionadministration & dosage
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Broader (4)

Inositol PhosphatesSecond Messenger Systemsinositol triphosphatesecond messenger

Narrower (2)

inositol 1,4,5-triphosphorothioateinositol 1,4,6-trisphosphate

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Inositol 1,4,5-Trisphosphate
physiological aspects
agonists
chemical synthesis
Inositol Phosphates
Calcium Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
Inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are channels responsible for calcium release from the endoplasmic… (More)
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Highly Cited
2000
Highly Cited
2000
A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control.
Phospholipase C and two inositol polyphosphate (IP) kinases constitute a signaling pathway that regulates nuclear messenger RNA… (More)
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Highly Cited
1999
Highly Cited
1999
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns.
Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2… (More)
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Highly Cited
1996
Highly Cited
1996
Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor.
The inositol 1,4,5-trisphosphate (InsP3) receptor acts as an InsP3-gated Ca2+ release channel in a variety of cell types. Type 1… (More)
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Highly Cited
1992
Highly Cited
1992
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
The range of messenger action of a point source of Ca2+ or inositol 1,4,5-trisphosphate (IP3) was determined from measurements of… (More)
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Highly Cited
1992
Highly Cited
1992
A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.
Relying on quantitative measurements of Ca2+ activation and inhibition of the inositol 1,4,5-trisphosphate (IP3) receptor in the… (More)
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Highly Cited
1991
Highly Cited
1991
Calcium as a coagonist of inositol 1,4,5-trisphosphate-induced calcium release.
Inositol 1,4,5-trisphosphate (IP3)-induced calcium release from intracellular stores is a regulator of cytosolic-free calcium… (More)
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Highly Cited
1989
Highly Cited
1989
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400.
Cloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for… (More)
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Highly Cited
1989
Highly Cited
1989
Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.
Hepatocytes are well coupled by gap junctions, which allow the diffusion of small molecules between cells. Although gap junctions… (More)
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Highly Cited
1983
Highly Cited
1983
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate.
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… (More)
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