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Inositol 1,4,5-Trisphosphate

Known as: 1,4,5-IP3, INs-P3, Myo-Inositol 1,4,5-Trisphosphate 
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make… Expand
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (3)

6-deoxyinositol 1,4,5-triphosphateinositol 1,4,5-triphosphorothioateinositol 1,4,6-trisphosphate
Calcium SignalingIn BloodProcess of secretionagonists
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Broader (4)

Inositol PhosphatesSecond Messenger Systemsinositol triphosphatesecond messenger

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2011
Review
2011
Modulation of striatal projection systems by dopamine.
The basal ganglia are a chain of subcortical nuclei that facilitate action selection. Two striatal projection systems--so-called… Expand
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Review
2009
Review
2009
Inositol trisphosphate and calcium signalling mechanisms.
Studies on control of fluid secretion by an insect salivary gland led to the discovery of inositol trisphosphate (IP3) and its… Expand
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Highly Cited
2004
Highly Cited
2004
Bcl-2 functionally interacts with inositol 1,4,5-trisphosphate receptors to regulate calcium release from the ER in response to inositol 1,4,5-trisphosphate
Inositol 1,4,5-trisphosphate (InsP3) receptors (InsP3Rs) are channels responsible for calcium release from the endoplasmic… Expand
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Highly Cited
1999
Highly Cited
1999
Spatiotemporal dynamics of inositol 1,4,5-trisphosphate that underlies complex Ca2+ mobilization patterns.
Inositol 1,4,5-trisphosphate (IP3) is a second messenger that elicits complex spatiotemporal patterns of calcium ion (Ca2… Expand
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Highly Cited
1997
Highly Cited
1997
Xestospongins: Potent Membrane Permeable Blockers of the Inositol 1,4,5-Trisphosphate Receptor
Xestospongins (Xe's) A, C, D, araguspongine B, and demethylxestospongin B, a group of macrocyclic bis-1-oxaquinolizidines… Expand
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Highly Cited
1992
Highly Cited
1992
Range of messenger action of calcium ion and inositol 1,4,5-trisphosphate.
The range of messenger action of a point source of Ca2+ or inositol 1,4,5-trisphosphate (IP3) was determined from measurements of… Expand
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Review
1989
Review
1989
Inositol phosphates and cell signalling
Inositol 1,4,5-trisphosphate is a second messenger which regulates intracellular calcium both by mobilizing calcium from internal… Expand
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Highly Cited
1989
Highly Cited
1989
Primary structure and functional expression of the inositol 1,4,5-trisphosphate-binding protein P400
Cloning and expression of functional P400 protein from cerebellar Purkinje neurons shows that this protein is a receptor for… Expand
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Highly Cited
1988
Highly Cited
1988
Inositol trisphosphate and calcium signaling.
The primary function of inositol 1,4,5-trisphosphate (InsP 3 ) is to function as a second messenger to release Ca 2+ from… Expand
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Highly Cited
1983
Highly Cited
1983
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate
Activation of receptors for a wide variety of hormones and neurotransmitters leads to an increase in the intracellular level of… Expand
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