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Inositol 1,4,5-Trisphosphate

Known as: 1,4,5-IP3, INs-P3, Myo-Inositol 1,4,5-Trisphosphate 
Intracellular messenger formed by the action of phospholipase C on phosphatidylinositol 4,5-bisphosphate, which is one of the phospholipids that make… 
National Institutes of Health

Related topics

Related topics

17 relations

Narrower (3)

6-deoxyinositol 1,4,5-triphosphateinositol 1,4,5-triphosphorothioateinositol 1,4,6-trisphosphate
Calcium SignalingIn BloodProcess of secretionagonists

Broader (4)

Inositol PhosphatesSecond Messenger Systemsinositol triphosphatesecond messenger

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Regulation of single inositol 1,4,5‐trisphosphate receptor channel activity by protein kinase A phosphorylation
Phosphorylation of inositol 1,4,5‐trisphosphate receptors (InsP3R) by PKA represents an important, common route for regulation of… 
Highly Cited
1992
Highly Cited
1992
Three additional inositol 1,4,5-trisphosphate receptors: molecular cloning and differential localization in brain and peripheral tissues.
Three inositol 1,4,5-trisphosphate receptor (IP3R) cDNAs, designated IP3R-II, -III, and -IV, were cloned from a mouse placenta… 
Highly Cited
1992
Highly Cited
1992
Cross-talk regulation between cyclic AMP production and phosphoinositide hydrolysis induced by prostaglandin E2 in osteoblast-like cells.
Highly Cited
1990
Highly Cited
1990
An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.
Recent studies in our laboratory have revealed the existence of an ATP- and calmodulin-dependent Ca2+ uptake system in rat liver… 
Highly Cited
1988
Highly Cited
1988
Cyclic Guanosine Monophosphate‐Enhanced Sequestration of Ca2+ by Sarcoplasmic Reticulum in Vascular Smooth Muscle
The purpose of this study was to investigate the effects of the intracellular messenger cyclic GMP (cGMP) on sequestration of… 
Highly Cited
1988
Highly Cited
1988
Inositol 1,4,5‐trisphosphate and diacylglycerol mimic bradykinin effects on mouse neuroblastoma x rat glioma hybrid cells.
1. The role of inositol 1,4,5‐trisphosphate (InsP3) and diacylglycerol (DAG) as possible mediators of the membrane current… 
Highly Cited
1986
Highly Cited
1986
Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein
To investigate the roles of inositol 1,4,5-trisphosphate (InsP3) and guanyl nucleotide binding proteins (G-proteins) in the… 
Highly Cited
1986
Highly Cited
1986
Regulation of the phosphoinositide hydrolysis pathway in thrombin-stimulated platelets by a pertussis toxin-sensitive guanine nucleotide-binding protein. Evaluation of its contribution to platelet…
Highly Cited
1985
Highly Cited
1985
A role for inositol triphosphate in intracellular Ca2+ mobilization and granule secretion in platelets.
Highly Cited
1984
Highly Cited
1984
The rapid formation of inositol phosphates in human platelets by thrombin is inhibited by prostacyclin.
The biochemical events underlying the ability of thrombin to enhance the metabolism of inositol phospholipids in human platelets… 
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