An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

  title={An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.},
  author={Pierluigi Nicotera and Sten Orrenius and Tina Nilsson and Per Olof Berggren},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 17},
Recent studies in our laboratory have revealed the existence of an ATP- and calmodulin-dependent Ca2+ uptake system in rat liver nuclei that can promote increases in the free Ca2+ concentration in the nuclear matrix. In the present investigation we show that liver nuclei possess a marked ability to sequester and buffer Ca2+, suggesting a potential role for the nucleus in the regulation of the cytosolic free Ca2+ concentration. In addition, we demonstrate that the intracellular messenger… CONTINUE READING


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J . Biol . Chem . 264 , 20863 - 20866

  • R. J. Tsien, D. J. Rink
  • 1989

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