Indoleamine 2,3-Dioxygenase, human

Known as: Indoleamine-Pyrrole 2,3-Dioxygenase, IDO, EC 1.13.11.52 
Indoleamine 2,3-dioxygenase (403 aa, ~45 kDa) is encoded by the human INDO gene. This protein is involved in the degradation of tryptophan.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1979-2018
051019792018

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Highly Cited
2012
Highly Cited
2012
Pain and depression are frequently comorbid disorders, but the mechanism underlying this association is unknown. Here, we report… (More)
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2009
2009
The role of the tryptophan-metabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in down-regulating human alloresponses has… (More)
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2009
2009
Human indoleamine 2,3-dioxygenase (hIDO) is an intracellular heme-containing enzyme, which catalyzes the initial and rate… (More)
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2008
2008
The initial step in the l-kynurenine pathway is oxidation of l-tryptophan to N-formylkynurenine and is catalyzed by one of two… (More)
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Highly Cited
2007
Highly Cited
2007
Indoleamine 2,3-dioxygenase (IDO) is induced by proinflammatory cytokines and by CTLA-4-expressing T cells and constitutes an… (More)
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Highly Cited
2007
Highly Cited
2007
Tryptophan 2,3-dioxygenase (TDO) and indoleamine 2,3-dioxygenase (IDO) constitute an important, yet relatively poorly understood… (More)
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Highly Cited
2006
Highly Cited
2006
Human indoleamine 2,3-dioxygenase (IDO) catalyzes the cleavage of the pyrrol ring of L-Trp and incorporates both atoms of a… (More)
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2004
2004
BACKGROUND Indoleamine 2,3-dioxygenase (IDO) is a tryptophan catabolic enzyme. Recent studies have focused on the… (More)
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2002
2002
Indoleamine 2,3-dioxygenase (IDO) has been implicated in regulation of feto-maternal tolerance and protection against… (More)
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1994
1994
Studies were carried out to evaluate the proposed role of indoleamine 2,3-dioxygenase (INDO) induction in the antimicrobial and… (More)
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