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Indoleamine 2,3-Dioxygenase, human

Known as: Indoleamine-Pyrrole 2,3-Dioxygenase, IDO, EC 1.13.11.52 
Indoleamine 2,3-dioxygenase (403 aa, ~45 kDa) is encoded by the human INDO gene. This protein is involved in the degradation of tryptophan.
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneHomo sapiensIDO1 geneOxidation-Reduction

Broader (2)

Indoleamine-Pyrrole 2,3,-DioxygenaseTryptophan Oxygenase

Papers overview

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2017
2017
Engineering and preclinical evaluation of a human enzyme immune checkpoint inhibitor for cancer therapy
The work presented here builds on the findings that the amino acid kynurenine (L-Kyn) synthesized via the enzymes indoleamine… 
2015
2015
Correction: IDO1 and IDO2 Non-Synonymous Gene Variants: Correlation with Crohn's Disease Risk and Clinical Phenotype
Review
2013
Review
2013
Inflammatory programming and immune modulation in cancer by IDO
Immune dysregulation is one of the hallmarks of tumor growth and progression, a key event that allows for tumor evasion of the… 
2012
2012
Tryptophan Metabolism-Indoleamine 2,3-Dioxygenase-Friend and Foe
1Indoleamine 2,3-dioxygenase (IDO) (EC 1.13.11.42) is a cytoplasmic, heme-containing enzyme that mediates the initial and rate… 
2010
2010
Synthesis of indole derivatives as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
Das immunsuppressive Enzym Indoleamine 2,3-dioxygenase, das eine Schlusselfunktion im Tryptophan- Metabolismus einnimmt, wird… 
2009
2009
Abstract #5670: Genetic definition of cancer inflammation: immune escape gene IDO is essential for inflammatory carcinogenesis
Chronic inflammation can drive tumor outgrowth but the precise nature of the pathways that define \#8216;cancer-associated… 
2008
2008
Indoleamine 2,3-dioxygenase (IDO) expression and malignant transformation in prostate cancer
2006
2006
EFFECT OF FLUORIDE AND MAGNESIUM ON IN VIVO ACTIVITY OF INDOLEAMINE 2 , 3-DIOXYGENASE IN RAT LUNGS
The physiological significance of the enzyme indoleamine 2,3,dioxygenase (IDO) (EC 1.13.11.17), which consumes superoxide anion… 
2005
2005
Stimulation of the immunotolerance-related molecule indoleamine 2,3-dioxygenase (IDO) in dendritic cells
2003
2003
Does chronic lung inflammation induce an increase in tryptophan catabolism through IDO (indoleamine 2,3-dioxygenase) pathway in pigs?