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Indoleamine 2,3-Dioxygenase, human
Known as:
Indoleamine-Pyrrole 2,3-Dioxygenase
, IDO
, EC 1.13.11.52
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Indoleamine 2,3-dioxygenase (403 aa, ~45 kDa) is encoded by the human INDO gene. This protein is involved in the degradation of tryptophan.
National Institutes of Health
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Related topics
Related topics
9 relations
Enzyme Gene
Homo sapiens
IDO1 gene
Oxidation-Reduction
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Broader (2)
Indoleamine-Pyrrole 2,3,-Dioxygenase
Tryptophan Oxygenase
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A Phase I study of NLG919 for adult patients with recurrent advanced solid tumors
Asha Nayak
,
Zhonglin Hao
,
+13 authors
S. Khleif
Journal of Immunotherapy for Cancer
2014
Corpus ID: 44346057
Meeting abstracts Clinical Trial Registration Number: [NCT02048709][1] The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes…
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Review
2013
Review
2013
The role of placental indoleamine 2,3-dioxygenase in human pregnancy
Y. Kudo
Obstetrics & Gynecology Science
2013
Corpus ID: 4785273
Munn et al. made a scientific observation of major biological importance. For the first time they showed that in the mammal the…
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2011
2011
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
S. Comai
,
L. Cavalletto
,
+4 authors
A. Bertazzo
Pharmacological Research
2011
Corpus ID: 24288862
Review
2010
Review
2010
Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs.
H. Hori
,
Y. Uto
,
Eiji Nakata
Anticancer Research
2010
Corpus ID: 24528479
We describe herein for the first time our medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and…
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Highly Cited
2006
Highly Cited
2006
Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast.
E. Vottero
,
A. Balgi
,
+5 authors
M. Roberge
Biotechnology Journal
2006
Corpus ID: 21759384
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan degradation enzyme that is emerging as an important drug target. IDO is…
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Review
2005
Review
2005
Marrying immunotherapy with chemotherapy: why say IDO?
A. Muller
,
G. Prendergast
Cancer Research
2005
Corpus ID: 6925725
Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A…
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2003
2003
Tryptophan metabolism was accelerated by exercise in rat.
Yasuhiro Ito
,
Reiko Yonekura
,
+5 authors
Y. Nagamura
Advances in Experimental Medicine and Biology
2003
Corpus ID: 37726858
We have already reported that exercise activates kynurenine pathway. But, the mechanism for this activation by exercise is still…
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2002
2002
HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno‐inhibitory phenotype through up‐regulation of indoleamine 2,3‐dioxygenase activity
G. Logan
,
C. Smyth
,
+4 authors
I. Alexander
Immunology
2002
Corpus ID: 20791545
The mechanisms by which tumour cells escape recognition by the immune system or subvert antitumour effector responses remain…
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Review
1996
Review
1996
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation.
O. Hayaishi
Advances in Experimental Medicine and Biology
1996
Corpus ID: 10389681
The following is our current working hypothesis concerning the biological significance of IDO induction. When tissues are invaded…
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Highly Cited
1995
Highly Cited
1995
Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1.
B. Hissong
,
G. Byrne
,
M. Padilla
,
J. Carlin
Cellular Immunology
1995
Corpus ID: 33302158
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