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Indoleamine 2,3-Dioxygenase, human

Known as: Indoleamine-Pyrrole 2,3-Dioxygenase, IDO, EC 1.13.11.52 
Indoleamine 2,3-dioxygenase (403 aa, ~45 kDa) is encoded by the human INDO gene. This protein is involved in the degradation of tryptophan.
National Institutes of Health

Related topics

Related topics

9 relations
Enzyme GeneHomo sapiensIDO1 geneOxidation-Reduction

Broader (2)

Indoleamine-Pyrrole 2,3,-DioxygenaseTryptophan Oxygenase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
A Phase I study of NLG919 for adult patients with recurrent advanced solid tumors
Meeting abstracts Clinical Trial Registration Number: [NCT02048709][1] The enzyme Indoleamine 2,3-dioxygenase (IDO1) catalyzes… 
Review
2013
Review
2013
The role of placental indoleamine 2,3-dioxygenase in human pregnancy
Munn et al. made a scientific observation of major biological importance. For the first time they showed that in the mammal the… 
2011
2011
Effects of PEG-interferon alpha plus ribavirin on tryptophan metabolism in patients with chronic hepatitis C.
Review
2010
Review
2010
Medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and invention of boron tracedrugs as innovative future-architectural drugs.
We describe herein for the first time our medicinal electronomics bricolage design of hypoxia-targeting antineoplastic drugs and… 
Highly Cited
2006
Highly Cited
2006
Inhibitors of human indoleamine 2,3-dioxygenase identified with a target-based screen in yeast.
Indoleamine 2,3-dioxygenase (IDO) is a tryptophan degradation enzyme that is emerging as an important drug target. IDO is… 
Review
2005
Review
2005
Marrying immunotherapy with chemotherapy: why say IDO?
Activation of the tryptophan catabolizing enzyme indoleamine 2,3-dioxygenase (IDO) in cancer cells facilitates immune escape. A… 
2003
2003
Tryptophan metabolism was accelerated by exercise in rat.
We have already reported that exercise activates kynurenine pathway. But, the mechanism for this activation by exercise is still… 
2002
2002
HeLa cells cocultured with peripheral blood lymphocytes acquire an immuno‐inhibitory phenotype through up‐regulation of indoleamine 2,3‐dioxygenase activity
The mechanisms by which tumour cells escape recognition by the immune system or subvert antitumour effector responses remain… 
Review
1996
Review
1996
Utilization of superoxide anion by indoleamine oxygenase-catalyzed tryptophan and indoleamine oxidation.
The following is our current working hypothesis concerning the biological significance of IDO induction. When tissues are invaded… 
Highly Cited
1995
Highly Cited
1995
Upregulation of interferon-induced indoleamine 2,3-dioxygenase in human macrophage cultures by lipopolysaccharide, muramyl tripeptide, and interleukin-1.
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