HlPT-1, a membrane-bound prenyltransferase responsible for the biosynthesis of bitter acids in hops.
- Yusuke Tsurumaru, Kanako Sasaki, K. Yazaki
- Biology, ChemistryBiochemical and Biophysical Research…
- 6 January 2012
Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolis.
- N. Paulino, S. Abreu, W. Bretz
- Biology, MedicineEuropean Journal of Pharmacology
- 10 June 2008
Suppression of tumor-induced angiogenesis by Brazilian propolis: major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation.
- Mok-Ryeon Ahn, Kazuhiro Kunimasa, T. Nakayama
- Biology, MedicineCancer Letters
- 18 July 2007
Sequential Aldol Condensation Catalyzed by Hyperthermophilic 2-Deoxy-d-Ribose-5-Phosphate Aldolase
- H. Sakuraba, K. Yoneda, T. Ohshima
- Chemistry, BiologyApplied and Environmental Microbiology
- 28 September 2007
To the authors' surprise, the two hyperthermophilic DERAs showed much greater catalysis of sequential aldol condensation using three acetaldehydes as substrates than the E. coli DERA, although both enzymes showed much less 2-deoxy-d-ribose-5-phosphate synthetic activity.
Tumor cell alpha-N-acetylgalactosaminidase activity and its involvement in GcMAF-related macrophage activation.
- S. Mohamad, H. Nagasawa, Y. Uto, H. Hori
- Biology, ChemistryComparative biochemistry and physiology. Part A…
- 1 May 2002
Gc protein (vitamin D-binding protein): Gc genotyping and GcMAF precursor activity.
- H. Nagasawa, Y. Uto, H. Hori
- BiologyAnticancer Research
- 1 November 2005
In this review, the structure and function of the Gc protein is focused on especially with regard to Gc genotyping and GcMAF precursor activity.
Correlation between antiangiogenic activity and antioxidant activity of various components from propolis.
- Mok-Ryeon Ahn, Kazuhiro Kunimasa, Toshiro Ohta
- BiologyMolecular Nutrition & Food Research
- 1 May 2009
Propolis components such as artepillin C, caffeic acid phenethyl ester, galangin, kaempferol, and quercetin might represent a new class of dietary-derived antioxidative compounds with antiangiogenic activities that may have the potential to be developed into pharmaceutical drugs for the treatment of angiogenesis-dependent human diseases such as tumors.
Hypoxia accelerates cancer invasion of hepatoma cells by upregulating MMP expression in an HIF-1alpha-independent manner.
- A. Miyoshi, Y. Kitajima, K. Miyazaki
- BiologyInternational Journal of Oncology
- 1 December 2006
In hepatoma cells, evidence is provided that hypoxic stress accelerates cancer invasion by upregulating ETS-1 and the MMP family by an HIF-1alpha-independent pathway.
Artepillin C (ARC) in Brazilian green propolis selectively blocks oncogenic PAK1 signaling and suppresses the growth of NF tumors in mice
- S. Messerli, Mok-Ryeon Ahn, H. Maruta
- BiologyPhytotherapy Research
- 1 March 2009
It was confirmed that ARC as well as GPE suppress almost completely the growth of human NF tumor xenografts in mice, as does Bio 30, suggesting that both CAPE‐based and ARC‐based propolis extracts are natural anti‐PAK1 remedies and could be among the first effective NF therapeutics available on the market.
TX-1123: an antitumor 2-hydroxyarylidene-4-cyclopentene-1,3-dione as a protein tyrosine kinase inhibitor having low mitochondrial toxicity.
- H. Hori, H. Nagasawa, Y. Uehara
- Biology, ChemistryBioorganic & Medicinal Chemistry
- 1 October 2002
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