IDO1 gene

Known as: INDO, INDOLEAMINE 2,3-DIOXYGENASE, IDO 
This gene is involved in the metabolism of the amino acid tryptophan.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1985-2018
05019852018

Papers overview

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Highly Cited
2013
Highly Cited
2013
The cytotoxic T lymphocyte antigen-4 (CTLA-4)-blocking antibody ipilimumab results in durable responses in metastatic melanoma… (More)
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Highly Cited
2011
Highly Cited
2011
Regulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) is a highly versatile modulator… (More)
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Highly Cited
2010
Highly Cited
2010
Cytokine-induced activation of indoleamine 2,3-dioxygenase (IDO) catabolizes L-tryptophan (TRP) into L-kynurenine (KYN), which is… (More)
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Highly Cited
2010
Highly Cited
2010
Ipilimumab, a fully human monoclonal antibody that blocks cytotoxic T-lymphocyte antigen-4, has demonstrated an improvement in… (More)
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Highly Cited
2009
Highly Cited
2009
Although elevated activity of the tryptophan-degrading enzyme indoleamine 2,3-dioxygenase (IDO) has been proposed to mediate… (More)
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Highly Cited
2008
Highly Cited
2008
Indoleamine-2,3-Dioxygenase (IDO) is an immunosuppressive molecule inducible in various cells. In addition to classic IDO (IDO1… (More)
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Highly Cited
2005
Highly Cited
2005
Immune escape is a crucial feature of cancer progression about which little is known. Elevation of the immunomodulatory enzyme… (More)
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Highly Cited
2005
Highly Cited
2005
Local catabolism of the amino acid tryptophan (Trp) by indoleamine 2,3-dioxygenase (IDO) is considered an important mechanism of… (More)
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Highly Cited
2002
Highly Cited
2002
Macrophages exposed to macrophage colony-stimulating factor acquire the capacity to suppress T cell proliferation; this effect is… (More)
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Highly Cited
2002
Highly Cited
2002
Antigen-presenting cells (APCs) can induce tolerance or immunity. We describe a subset of human APCs that express indoleamine 2,3… (More)
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