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Inamrinone

Known as: Amrinona, Amrinone, Amrinonum 
A synthetic bipyridine phosphodiesterase inhibitor with inotropic and vasodilator properties. Inamrinone inhibits type III phosphodiesterase, which… 
National Institutes of Health

Related topics

Related topics

29 relations
100 ML Milrinone Lactate 0.2 MG/ML InjectionAortic Valve InsufficiencyCardiomyopathy, DilatedCongestive heart failure

Narrower (6)

AmcoralCordemcuraInocorN-acetylamrinone

Broader (4)

Calcium Channel BlockersCardiotonic AgentsPhosphodiesterase 3 InhibitorsVasodilator Agents

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Effect Unveils Inter-head Cooperativity and Strain-dependent ADP Release in Fast Skeletal Actomyosin
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle… 
1996
1996
The In Vitro Effects of Phosphodiesterase Inhibitors on the Human Internal Mammary Artery
The internal mammary artery (IMA) is the preferred conduit for myocardial revascularization, but it changes diameter in response… 
1987
1987
A novel class of cardiotonics. Synthesis and pharmacological properties of [4-(substituted-amino)phenyl]pyridazinones and related derivatives.
A series of [4-(substituted-amino)phenyl]pyridazinones and [4-(substituted-methyl)amino]phenyl]pyridazinones was synthesized and… 
Highly Cited
1986
Highly Cited
1986
Pharmacology of the bipyridines: amrinone and milrinone.
: The cardiovascular bipyridines amrinone and milrinone are positive inotropic agents with vasodilator properties. When their… 
1986
1986
Effect of amrinone on right ventricular function: predominance of afterload reduction.
Although the bipyridine agent amrinone is reported to have a positive inotropic effect on the left ventricle, the effect of this… 
1986
1986
Augmentation of cardiac function in end-stage heart failure by combined use of dobutamine and amrinone.
A patient with end-stage congestive cardiomyopathy had progressive hemodynamic deterioration while awaiting orthotopic heart… 
Highly Cited
1984
Highly Cited
1984
Comparison of the effects of amrinone and sodium nitroprusside on haemodynamics, contractility, and myocardial metabolism in patients with cardiac failure due to coronary artery disease and dilated…
The effects of intravenous amrinone and sodium nitroprusside on haemodynamic indices, left ventricular contractility, and… 
1984
1984
Amrinone-induced thrombocytopenia.
The frequency and characteristics of thrombocytopenia resulting from administration of amrinone, a new inotropic and vasodilator… 
1983
1983
Oral bioavailability and intravenous pharmacokinetics of amrinone in humans.
Fourteen healthy males received two 75-mg doses of amrinone as a single capsule and as an intravenous solution in a single-dose… 
1982
1982
Amrinone Activates K+‐Depolarized Atrial and Ventricular Myocardium of Guinea Pigs
Amrinone is a new synthetic drug that increases contractile strength of mammalian heart muscle; however, its mechanism of…