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Fiber Orientation in the Canine Left Ventricle during Diastole and Systole
The wall has a well-ordered distribution of fiber angles varying from about 60° (from the circumferential direction) at the inner surface to about –60° on the outer surface, and the greatest change in angle occurs at the two surfaces (endocardial and epicardial). Expand
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.
Programmed myocyte cell death is the major form of myocardial damage produced by occlusion of a major epicardial coronary artery, whereas necrotic myocytes cell death follows apoptosis and contributes to the progressive loss of cells with time after infarction. Expand
Myocyte Death in Streptozotocin-Induced Diabetes in Rats Is Angiotensin II- Dependent
Diabetes may be viewed as an AT II-dependent process in which that peptide plays a critical role in myocyte death and hypertrophy, which prevented AT II synthesis and myocytes death at their peaks with diabetes. Expand
Altered Myocardial Mechanics in Diabetic Rats
A cardiomyopathic state has been produced in the rat consequent to the induction of experimental diabetes mellitus, showing abnor-malities in calcium uptake by sarcoplasmic reticulum and depressed actomyosin ATPase activity. Expand
Structural basis of end-stage failure in ischemic cardiomyopathy in humans.
Results are consistent with the contention that both myocyte and collagen compartments participate in the development of decompensated eccentric ventricular hypertrophy in the cardiomyopathic heart of ischemic origin. Expand
Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.
In conclusion, myocyte cellular hyperplasia tends to regenerate the ventricular mass being lost with age in the adult mammalian rat heart. Expand
Force-velocity relations in mammalian heart muscle.
  • E. Sonnenblick
  • Chemistry, Medicine
  • The American journal of physiology
  • 1 May 1962
Force-velocity relations were studied in the cat papillary muscle and a characteristic relation has been demonstrated between the velocity of shortening (V) and the force deve... Expand
Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure
It is concluded that congestive heart failure is associated with extreme quantitative abnormalities of the intrinsic contractile state of each unit of heart muscle, which reflect a depression in the intensity of the active state. Expand
Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats.
Side-to-side slippage of myocytes in the myocardium occurs in association with ventricular dilatation after a large myocardial infarction and contributes to ventricular remodeling and the occurrence of decompensated eccentric hypertrophy. Expand
Depressed cardiac sarcoplasmic reticular function from diabetic rats.
Calcium uptake by isolated sarcoplasmic reticulum in the absence of oxalate were significantly lower in preparations from hearts of diabetic males and females than from controls, which may partially explain the abnormalities in contraction and relaxation previously observed in Hearts of diabetic animals. Expand