Fiber Orientation in the Canine Left Ventricle during Diastole and Systole
- D. D. Streeter, H. Spotnitz, D. P. Patel, J. Ross, E. Sonnenblick
- BiologyCirculation Research
- 1 March 1969
The wall has a well-ordered distribution of fiber angles varying from about 60° (from the circumferential direction) at the inner surface to about –60° on the outer surface, and the greatest change in angle occurs at the two surfaces (endocardial and epicardial).
Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.
- J. Kajstura, W. Cheng, P. Anversa
- BiologyLaboratory investigation; a journal of technical…
- 1996
Programmed myocyte cell death is the major form of myocardial damage produced by occlusion of a major epicardial coronary artery, whereas necrotic myocytes cell death follows apoptosis and contributes to the progressive loss of cells with time after infarction.
Myocyte Death in Streptozotocin-Induced Diabetes in Rats Is Angiotensin II- Dependent
- F. Fiordaliso, Baosheng Li, J. Kajstura
- BiologyLaboratory Investigation
- 1 April 2000
Diabetes may be viewed as an AT II-dependent process in which that peptide plays a critical role in myocyte death and hypertrophy, which prevented AT II synthesis and myocytes death at their peaks with diabetes.
Altered Myocardial Mechanics in Diabetic Rats
- F. Fein, L. Kornstein, J. Strobeck, J. Capasso, E. Sonnenblick
- Biology, MedicineCirculation Research
- 1 December 1980
A cardiomyopathic state has been produced in the rat consequent to the induction of experimental diabetes mellitus, showing abnor-malities in calcium uptake by sarcoplasmic reticulum and depressed actomyosin ATPase activity.
Structural basis of end-stage failure in ischemic cardiomyopathy in humans.
- C. Beltrami, N. Finato, P. Anversa
- Medicine, BiologyCirculation
- 1994
Results are consistent with the contention that both myocyte and collagen compartments participate in the development of decompensated eccentric ventricular hypertrophy in the cardiomyopathic heart of ischemic origin.
Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.
- P. Anversa, T. Palackal, E. Sonnenblick, G. Olivetti, L. Meggs, J. Capasso
- Biology, MedicineCirculation Research
- 1 October 1990
In conclusion, myocyte cellular hyperplasia tends to regenerate the ventricular mass being lost with age in the adult mammalian rat heart.
Force-velocity relations in mammalian heart muscle.
- E. Sonnenblick
- Education, BiologyAmerican Journal of Physiology
- 1 May 1962
Force-velocity relations were studied in the cat papillary muscle and a characteristic relation has been demonstrated between the velocity of shortening (V) and the force deve...
Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure
- J. Spann, R. Buccino, E. Sonnenblick, E. Braunwald
- Biology, MedicineCirculation Research
- 1 September 1967
It is concluded that congestive heart failure is associated with extreme quantitative abnormalities of the intrinsic contractile state of each unit of heart muscle, which reflect a depression in the intensity of the active state.
Influence of Right Ventricular Filling Pressure on Left Ventricular Pressure and Dimension
- C. Bemis, J. Serur, D. Borkenhagen, E. Sonnenblick, C. W. Urschel
- Engineering, MedicineCirculation Research
- 1 April 1974
The data suggest that the high RV filling pressures that characterize certain diseases can secondarily alter LV filling pressures and geometry, and that LV end- diastolic geometry was increasingly distorted at elevated RV end-diastolic pressure.
Relation of Ultrastructure to Function in the Intact Heart: Sarcomere Structure Relative to Pressure Volume Curves of Intact Left Ventricles of Dog and Cat
- H. Spotnitz, E. Sonnenblick, D. Spiro
- BiologyCirculation Research
- 1 January 1966
The present results indicate that the normal left ventricle functions along the ascending portion of the length-tension curve, where the end diastolic sarcomere lengths are 2.2 μ or less.
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