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Fiber Orientation in the Canine Left Ventricle during Diastole and Systole
Fiber orientation across the left ventricular myocardial wall has been studied. Specimens were obtained from 18 dog hearts rapidly fixed in situ in systole, in diastole, and in dilated diastole.Expand
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Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats.
Programmed cell death in the myocardium has been linked to ischemia reperfusion injury as well as to excessive mechanical forces associated with increases in ventricular loading. Moreover, hypoxiaExpand
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Myocyte Death in Streptozotocin-Induced Diabetes in Rats Is Angiotensin II- Dependent
To determine whether myocyte death and angiotensin II (AT II) formation are implicated in the development of diabetic cardiomyopathy, rats were injected with streptozotocin, and apoptosis andExpand
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Altered Myocardial Mechanics in Diabetic Rats
Diabetes mellitus is associated frequently with congestive heart failure in humans, even in the absence of associated coronary disease or hypertension. Nevertheless, the effects of the diabetic stateExpand
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Structural basis of end-stage failure in ischemic cardiomyopathy in humans.
BACKGROUND Ischemic cardiomyopathy is characterized by myocyte loss, reactive cellular hypertrophy, and ventricular scarring. However, the relative contribution of these tissue and cellular processesExpand
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Myocyte cell loss and myocyte cellular hyperplasia in the hypertrophied aging rat heart.
To determine the effects of age on the myocardium, the functional and structural characteristics of the heart were studied in rats at 4, 12, 20, and 29 months of age. Mean arterial pressure, leftExpand
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Force-velocity relations in mammalian heart muscle.
  • E. Sonnenblick
  • Medicine, Chemistry
  • The American journal of physiology
  • 1 May 1962
Force-velocity relations were studied in the cat papillary muscle. As with skeletal muscle, a characteristic relation has been demonstrated between the velocity of shortening (V) and the forceExpand
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Side-to-side slippage of myocytes participates in ventricular wall remodeling acutely after myocardial infarction in rats.
To determine whether acute left ventricular failure associated with myocardial infarction leads to architectural changes in the spared nonischemic portion of the ventricular wall, large infarcts wereExpand
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Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure
The contractile state of papillary muscles from hypertrophied and from failing right ventricles of cats with pulmonary artery constriction was studied. In muscles from failing hearts, the maximumExpand
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Cellular basis of chronic ventricular remodeling after myocardial infarction in rats.
To determine whether the hypertrophic response of the surviving myocardium after infarction leads to normalization of ventricular hemodynamics and wall stress, the left coronary artery was ligated inExpand
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