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Impromidine

Known as: Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, Impromidine [Chemical/Ingredient] 
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
National Institutes of Health

Related topics

Related topics

8 relations

Broader (1)

Histamine Agonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Receptor-specific functional efficacies of alkyl imidazoles as dual histamine H3/H4 receptor ligands.
Histamine H(3) and H(4) receptors are highly related G protein-coupled receptors. Preclinical and clinical data strongly suggest… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of noradrenaline release in the rat brain cortex via presynaptic H3 receptors
SummaryThe effects of histamine and related drugs on the evoked tritium overflow from superfused rat brain cortex slices… Expand
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Highly Cited
2004
Highly Cited
2004
Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex
SummaryRat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing… Expand
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Highly Cited
1998
Highly Cited
1998
Characteristics of histamine-induced leukocyte rolling in the undisturbed microcirculation of the rat mesentery.
1. The main objective of this study was to analyse the role and mode of action of the mast cell mediator histamine in leukocyte… Expand
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Highly Cited
1996
Highly Cited
1996
Histaminergic descending inputs to the mesopontine tegmentum and their role in the control of cortical activation and wakefulness in the cat.
We have demonstrated previously the importance of histaminergic neurons in arousal mechanisms. In addition to their ascending… Expand
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Highly Cited
1992
Highly Cited
1992
Histamine H3 receptors modulate the release of [3H]-acetylcholine from slices of rat entorhinal cortex: evidence for the possible existence of H3 receptor subtypes.
1. The effect of agents which interact with the histamine H3 receptor on potassium-stimulated tritium release from slices of rat… Expand
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Highly Cited
1987
Highly Cited
1987
Autoinhibition of histamine synthesis mediated by presynaptic H3-receptors
The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with L-[3H]histidine… Expand
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Highly Cited
1985
Highly Cited
1985
Actions of betahistine at histamine receptors in the brain.
The actions of betahistine (N alpha-methyl-2-pyridylethylamine) on brain histamine receptors were investigated in a series of… Expand
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Highly Cited
1985
Highly Cited
1985
Autoregulation of histamine release in brain by presynaptic H3-receptors
Regulation of histamine release was studied mainly on brain slices prelabeled with L-[3H]-histidine and depolarized by increased… Expand
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1978
1978
Impromidine (SK&F 92676) is a very potent and specific agonist for histamine H2 receptors
PREVIOUSLY described selective agonists for histamine H2 receptors are 4-methylhistamine1, related congeners2–6 and dimaprit7… Expand
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