Impromidine

Histamine H(3) and H(4) receptors are highly related G protein-coupled receptors. Preclinical and clinical data strongly suggest… Expand

We have demonstrated previously the importance of histaminergic neurons in arousal mechanisms. In addition to their ascending… Expand

Cats were chronically implanted with electrodes for polygraphic recordings and cannulae for intracerebral microinjections in… Expand

1 The effect of agents which interact with the histamine H3 receptor on potassium‐stimulated tritium release from slices of rat… Expand

The H3-histamine receptor provides feedback inhibition of histamine synthesis and release as well as inhibition of other… Expand

The regulation of histamine synthesis was studied on rat brain slices or synaptosomes labeled with L-[3H]histidine… Expand

Regulation of histamine release was studied mainly on brain slices prelabeled with L-[3H]-histidine and depolarized by increased… Expand

The actions of betahistine (N alpha-methyl-2-pyridylethylamine) on brain histamine receptors were investigated in a series of… Expand

Impromidine (1) is a potent and selective histamine H2 receptor agonist and its structure comprises a strongly basic guanidine… Expand

PREVIOUSLY described selective agonists for histamine H2 receptors are 4-methylhistamine1, related congeners2–6 and dimaprit7… Expand