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Impromidine

Known as: Guanidine, N-(3-(1H-imidazol-4-yl)propyl)-N'-(2-(((5-methyl-1H-imidazol-4-yl)methyl)thio)ethyl)-, Impromidine [Chemical/Ingredient] 
A highly potent and specific histamine H2 receptor agonist. It has been used diagnostically as a gastric secretion indicator.
National Institutes of Health

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Broader (1)

Histamine Agonists
In Bloodagonistsanalogs & derivativesantagonists & inhibitors

Papers overview

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1995
1995
Effect of the histamine-2 agonist impromidine on stem cell proliferation of rat oxyntic mucosa.
BACKGROUND The trophic effect of gastrin on the histamine-containing enterochromaffin-like cell is pronounced but on the stem… 
1994
1994
Histamine receptors in the human nose.
The aim of this study was to determine the role of histamine receptors in the nose. The effects of intranasal histamine challenge… 
1991
1991
Therapeutic value of H2-receptor stimulation in congestive heart failure. Hemodynamic effects of BU-E-76, BU-E-75 and arpromidine (BU-E-50) in comparison to impromidine.
Previous studies from our department revealed that congestive heart failure (CHF) is paralleled by a decrease in number of… 
1990
1990
Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine
SummaryHuman neutrophils possess an NADPH oxidase which catalyzes superoxide (Oinf2sup−) formation and is activated by… 
Highly Cited
1989
Highly Cited
1989
Histamine release in the isolated vascularly perfused stomach of the rat: regulation by autoreceptors
1 In the isolated vascularly‐perfused stomach of the rat, gastrin 1–17 (520 pmol l−1) increased acid output from basal values of… 
1988
1988
Characterization of histamine receptors in isolated human cerebral arteries
1 The subtypes of histamine‐receptors which mediate dilatation of small human cerebral arteries have been characterized in vitro… 
1986
1986
Impromidine is a partial histamine H2‐receptor agonist on human ventricular myocardium
1 The inotropic effects of impromidine have been studied and compared with those of histamine on human isolated left ventricular… 
Highly Cited
1982
Highly Cited
1982
Pharmacological modification of immunoregulatory T lymphocytes. I. Effect of adenosine, H1 and H2 histamine agonists upon T lymphocyte regulation of B lymphocyte differentiation in vitro.
Human peripheral blood T lymphocytes were fractionated according to the lability of their sheep red blood cell (E) receptors to… 
1980
1980
Prolactin responses to histamine H2 receptor antagonists.
We have compared the effects of cimetidine and SK&F 92994, a new more potent histamine H2 receptor antagonist, on serum prolactin… 
1979
1979
Cardiovascular studies with impromidine (SK&F 92676), a new very potent and specific histamine H2‐receptor agonist
Impromidine (SK & F 92676) has recently been identified as a potent and specific histamine H2‐receptor agonist. The present paper… 
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