Imipramine Hydrochloride

Known as: Imipramine Hydrochloride [Chemical/Ingredient], Imipramine Monohydrochloride, imipramine hcl 
The hydrochloride salt form of imipramine, a synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in… (More)
National Institutes of Health

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1958-2016
0519582016

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Affective Disorders, PsychoticAntidepressive AgentsAttention deficit hyperactivity disorderCYP1A2 protein, human
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Tofranil

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1936-2019
19401960198020002020
Imipramine Hydrochloride
Depressive disorder
Pain
Drug Allergy
Myocardial Infarction
Pregnancy

Papers overview

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Highly Cited
2002
Highly Cited
2002
Transdermal drug delivery of imipramine hydrochloride. I. Effect of terpenes.
The objective of this investigation was to study the effect of different terpenes on IMH permeation in EtOH:W (2:1) system… (More)
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Highly Cited
1993
Highly Cited
1993
Antidepressants for the treatment of generalized anxiety disorder. A placebo-controlled comparison of imipramine, trazodone, and diazepam.
OBJECTIVE The current study examines whether antidepressants, contrary to current thinking, are safe and effective treatments for… (More)
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Highly Cited
1992
Highly Cited
1992
Cognitive therapy and pharmacotherapy for depression. Singly and in combination.
Cognitive therapy and imipramine hydrochloride tricyclic pharmacotherapy, each singly and in combination, were compared in the… (More)
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Highly Cited
1992
Highly Cited
1992
Differential relapse following cognitive therapy and pharmacotherapy for depression.
Patients successfully treated during a 3-month period with either imipramine hydrochloride pharmacotherapy, cognitive therapy, or… (More)
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Highly Cited
1990
Highly Cited
1990
Three-year outcomes for maintenance therapies in recurrent depression.
We conducted a randomized 3-year maintenance trial in 128 patients with recurrent depression who had responded to combined short… (More)
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Highly Cited
1989
Highly Cited
1989
National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments.
We investigated the effectiveness of two brief psychotherapies, interpersonal psychotherapy and cognitive behavior therapy, for… (More)
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1988
1988
Imipramine treatment for chronic depression.
Antidepressant drugs in the treatment of chronic depressions have received little systematic study. We used a two-week, single… (More)
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Highly Cited
1984
Highly Cited
1984
Drug therapy in the prevention of recurrences in unipolar and bipolar affective disorders. Report of the NIMH Collaborative Study Group comparing lithium carbonate, imipramine, and a lithium…
In a double-blind, long-term follow-up study, 117 bipolar patients received lithium carbonate, imipramine hydrochloride, or both… (More)
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1983
1983
Treatment of phobias. I. Comparison of imipramine hydrochloride and placebo.
In a controlled-outcome study of phobias, 218 adult phobic patients (147 women and 71 men) received a course of 26 weekly… (More)
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1979
1979
The electrocardiographic and antiarrhythmic effects of imipramine hydrochloride at therapeutic plasma concentrations.
The electrocardiographic effects of imipramine hydrochloride at therapeutic plasma concentrations were determined in 44 depressed… (More)
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