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Changes in α-adrenoceptor number and function in brains of morphine-dependent rats
Platelet alpha 2-adrenergic receptor binding and plasma catecholamines. Before and during imipramine treatment in patients with panic anxiety.
- O. Cameron, C. Smith, P. J. Hollingsworth, R. Nesse, G. Curtis
- Psychology, MedicineArchives of general psychiatry
- 1 December 1984
Treatment with imipramine hydrochloride decreased the number of sites, as measured with either ligand, in both patient groups and increased catecholamine levels in patients with panic attacks.
Platelet alpha2 adrenoreceptors are decreased in number after antidepressant therapy
Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment.
- J. García-Sevilla, A. Zis, P. J. Hollingsworth, J. Greden, C. Smith
- Psychology, BiologyArchives of general psychiatry
- 1 December 1981
The hypothesis that the depressive syndrome is related to an alpha 2-adrenergic receptor supersensitivity and that the clinical effectiveness of tricyclic antidepressant drugs is associated with a decrease in the number of these receptors is supported.
Adrenergic status in anxiety disorders: Platelet alpha2-adrenergic receptor binding, blood pressure, pulse, and plasma catecholamines in panic and generalized anxiety disorders patients and in normal…
Platelet alpha2-Adrenoreceptors, Catecholamines, Hemodynamic Variables, and Anxiety in Panic Patients and Their Asymptomatic Relatives
Both patients and relatives of patients showed significantly increased standing plasma norepinephrine in comparison to controls, suggesting there is a state-related decrease in binding, associated with symptom severity and norpinephrine, in panic disorder.
α2-Adrenoreceptors in rat brain are decreased after long-term tricyclic antidepressant drug treatment
Alpha 2-adrenoreceptors on human platelets: selective labelling by [3H]clonidine and [3H]yohimbine and competitive inhibition by antidepressant drugs.
Variation in cell surface features of Candida albicans with respect to carbon sources.
Clinical isolates of C. albicans were grown in defined media with various carbon sources then examined by scanning electron microscopy in an attempt to note changes in cell surface features. The mode…
Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension.
- D. Abrahm, P. J. Hollingsworth, A. Vinik
- Medicine, BiologyThe Journal of clinical endocrinology and…
- 1 October 1986
Diabetic patients with diabetic autonomic neuropathy and orthostatic hypotension had a 30-40% decrease in number of platelet alpha 2-adrenergic receptors, as demonstrated by [3H]clonidine and yohimbine binding, and reduced vascular responses to changes in posture would be expected despite normal or enhanced norepinephrine secretion.