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Platelet alpha 2-adrenergic receptor binding and plasma catecholamines. Before and during imipramine treatment in patients with panic anxiety.
Treatment with imipramine hydrochloride decreased the number of sites, as measured with either ligand, in both patient groups and increased catecholamine levels in patients with panic attacks.
Platelet alpha 2-adrenergic receptors in major depressive disorder. Binding of tritiated clonidine before and after tricyclic antidepressant drug treatment.
The hypothesis that the depressive syndrome is related to an alpha 2-adrenergic receptor supersensitivity and that the clinical effectiveness of tricyclic antidepressant drugs is associated with a decrease in the number of these receptors is supported.
Platelet alpha2-Adrenoreceptors, Catecholamines, Hemodynamic Variables, and Anxiety in Panic Patients and Their Asymptomatic Relatives
Both patients and relatives of patients showed significantly increased standing plasma norepinephrine in comparison to controls, suggesting there is a state-related decrease in binding, associated with symptom severity and norpinephrine, in panic disorder.
Variation in cell surface features of Candida albicans with respect to carbon sources.
Clinical isolates of C. albicans were grown in defined media with various carbon sources then examined by scanning electron microscopy in an attempt to note changes in cell surface features. The mode
Decreased alpha 2-adrenergic receptors on platelet membranes from diabetic patients with autonomic neuropathy and orthostatic hypotension.
Diabetic patients with diabetic autonomic neuropathy and orthostatic hypotension had a 30-40% decrease in number of platelet alpha 2-adrenergic receptors, as demonstrated by [3H]clonidine and yohimbine binding, and reduced vascular responses to changes in posture would be expected despite normal or enhanced norepinephrine secretion.