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Imetelstat

Known as: DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate] 
A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the… Expand
National Institutes of Health

Papers overview

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2016
2016
Telomerase activation is critical in many cancers including central nervous system (CNS) tumors. Imetelstat is an oligonucleotide… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Current drugs for myeloproliferative neoplasm-associated myelofibrosis, including Janus kinase (JAK) inhibitors, do… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Continuation or 'switch' maintenance therapy is commonly used in patients with advancd non-small-cell lung cancer… Expand
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2014
2014
Telomerase is required for the unlimited lifespan of cancer cells. The vast majority of pancreatic adenocarcinomas overexpress… Expand
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2012
2012
Telomerase is mainly active in human tumor cells, which provides an opportunity for a therapeutic window on telomerase targeting… Expand
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Highly Cited
2011
Highly Cited
2011
Specific information about how telomerase acts in vivo is necessary for understanding telomere dynamics in human tumor cells. Our… Expand
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Highly Cited
2010
Highly Cited
2010
PURPOSE Telomerase activity is one of the hallmarks of cancer and is a highly relevant therapeutic target. The effects of a novel… Expand
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Review
2010
Review
2010
Telomeres and telomerase play essential roles in the regulation of the lifespan of human cells. While normal human somatic cells… Expand
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Highly Cited
2010
Highly Cited
2010
Cancer stem cells (CSC) are rare drug-resistant cancer cell subsets proposed to be responsible for the maintenance and recurrence… Expand
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