Imetelstat

Known as: DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate] 
A synthetic lipid-conjugated, 13-mer oligonucleotide N3'-P5'-thio-phosphoramidate with potential antineoplastic activity. Complementary to the… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2018
0520102018

Papers overview

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2015
2015
BACKGROUND Current drugs for myeloproliferative neoplasm-associated myelofibrosis, including Janus kinase (JAK) inhibitors, do… (More)
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2015
2015
BACKGROUND Imetelstat, a 13-mer oligonucleotide that is covalently modified with lipid extensions, competitively inhibits… (More)
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2015
2015
BACKGROUND Continuation or 'switch' maintenance therapy is commonly used in patients with advancd non-small-cell lung cancer… (More)
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2015
2015
The unsatisfactory outcomes for osteosarcoma necessitate novel therapeutic strategies. This study evaluated the effect of the… (More)
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2013
2013
PURPOSE Imetelstat is a covalently-lipidated 13-mer thiophosphoramidate oligonucleotide that acts as a potent specific inhibitor… (More)
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2012
2012
Telomerase is mainly active in human tumor cells, which provides an opportunity for a therapeutic window on telomerase targeting… (More)
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2010
2010
Cancer stem cells (CSC) are rare drug-resistant cancer cell subsets proposed to be responsible for the maintenance and recurrence… (More)
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Highly Cited
2010
Highly Cited
2010
PURPOSE Telomerase activity is one of the hallmarks of cancer and is a highly relevant therapeutic target. The effects of a novel… (More)
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2010
2010
Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most… (More)
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