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Imetelstat Sodium

Known as: DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate], Sodium Salt (1:13), telomerase inhibitor GRN163L 
The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic… 
National Institutes of Health

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Papers overview

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2020
2020
JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L.
2016
2016
Identification and characterisation of telomere regulatory and signalling pathways after induction of telomere dysfunction
Telomeres are DNA-protein complexes which cap the ends of eukaryotic linear chromosomes. In normal somatic cells telomeres… 
2015
2015
Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status
Introduction. The high telomerase activity in leukemia cells protects them from proliferation arrest, senescence, and apoptosis… 
2013
2013
Progress in Telomerase Inhibitor GRN163L in the Treatment for Cancer
GRN163L(Geron Presentations on Imetelstat) is an antisense nucleotide drugs armming at hTR(telomerase RNA),which can inhibit the… 
2010
2010
Antimetastatic Effects of a Novel Telomerase Inhibitor, GRN163L, on Human Prostate Cancer
Abstract : Prostate adenocarcinoma is the most common type of cancer found in men, being second to lung cancer in terms of… 
2010
2010
Abstract 3207: Telomerase inhibition affects fludarabine sensitivity in quiescent primary chronic lymphocytic leukemia lymphocytes
B- Cell chronic leukemia (CLL) is the most common leukemia in adults. It is clinically very heterogeneous and has a highly… 
2009
2009
Telomerase Inhibitor GRN163L as a Potential Antiangiogenic Agent for Neovascular Eye Diseases
2009
2009
Leukemic T-PLL Cells Exhibit Short and Narrowly Distributed Telomere Lengths and High Telomerase Activities, Associated with Rapid and Dose-Dependent Cell Death Following Telomerase Inhibition by…
Abstract 2647 Poster Board II-623 Background/Aims: Reflecting their proliferative history, malignant cells generally have shorter… 
2007
2007
The novel telomerase inhibitor GRN163L targets drug-resistant cancer stem cells in multiple myeloma
A97 The majority of chronic hematologic malignancies are responsive to initial treatment using standard agents, but most patients… 
2006
2006
628 POSTER Single agent and combination treatment studies with the telomerase inhibitor GRN163L in ovarian cancer and non-small cell lung carcinoma (NSCLC) xenograft models
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