Skip to search formSkip to main contentSkip to account menu

Imetelstat Sodium

Known as: DNA, d(3'-amino-3'-deoxy-P-thio)(T-A-G-G-G-T-T-A-G-A-C-A-A), 5'-[O-[2-hydroxy-3- [(1-oxohexadecyl)amino]propyl] hydrogen phosphorothioate], Sodium Salt (1:13), telomerase inhibitor GRN163L 
The sodium salt of imetelstat, a synthetic lipid-conjugated, 13-mer oligonucleotide N3' P5'-thio-phosphoramidate with potential antineoplastic… 
National Institutes of Health

Related topics

Related topics

2 relations

Narrower (1)

Grn163l
Imetelstat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
Investigational non-JAK inhibitors for chronic phase myelofibrosis
ABSTRACT Introduction Patients with myelofibrosis (MF) have no effective treatment option after the failure of approved JAK… 
2020
2020
JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L.
2015
2015
Activity of the Telomerase Inhibitor GRN163L (Imetelstat) on Acute Myeloblastic Leukemia Blasts Is Enhanced By DNA Methyltransferase Inhibitors Irrespective of TERT Promoter Methylation Status
Introduction. The high telomerase activity in leukemia cells protects them from proliferation arrest, senescence, and apoptosis… 
2013
2013
Imetelstat (a telomerase antagonist) exerts off-target effects on the cytoskeleton
Telomerase is a cellular ribonucleoprotein reverse transcriptase that plays a crucial role in telomere maintenance. This enzyme… 
2010
2010
The Effect of Telomerase Template Antagonist GRN163L on Bone-Marrow-Derived Rat Mesenchymal Stem Cells is Reversible and Associated with Altered Expression of Cyclin d1, cdk4 and cdk6
Telomerase activity is essential for the continued growth and survival of malignant cells, therefore inhibition of this activity… 
Highly Cited
2010
Highly Cited
2010
The effects of telomerase inhibition on prostate tumor‐initiating cells
Prostate cancer is the most common malignancy in men, and patients with metastatic disease have poor outcome even with the most… 
2009
2009
Telomerase Inhibitor GRN163L as a Potential Antiangiogenic Agent for Neovascular Eye Diseases
Highly Cited
2008
Highly Cited
2008
Telomerase inhibitor GRN163L inhibits myeloma cell growth in vitro and in vivo
Human telomerase, the reverse transcriptase which extends the life span of a cell by adding telomeric repeats to chromosome ends… 
2007
2007
The novel telomerase inhibitor GRN163L targets drug-resistant cancer stem cells in multiple myeloma
A97 The majority of chronic hematologic malignancies are responsive to initial treatment using standard agents, but most patients… 
2006
2006
628 POSTER Single agent and combination treatment studies with the telomerase inhibitor GRN163L in ovarian cancer and non-small cell lung carcinoma (NSCLC) xenograft models
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)