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Grn163l

Known as: GRN163L, Sodium Salt 
National Institutes of Health

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Broader (1)

Imetelstat Sodium

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
JAK2 inhibition in JAK2V617F-bearing leukemia cells enriches CD34+ leukemic stem cells that are abolished by the telomerase inhibitor GRN163L.
2017
2017
Inhibitors of telomerase and poly(ADP-ribose) polymerases synergize to limit the lifespan of pancreatic cancer cells
Imetelstat (GRN163L) is a potent and selective inhibitor of telomerase. We have previously reported that GRN163L could shorten… 
2015
2015
TR-11A MOLECULAR BIOLOGY AND PHASE II STUDY OF IMETELSTAT (GRN163L) IN CHILDREN WITH RECURRENT OR REFRACTORY CENTRAL NERVOUS SYSTEM (CNS) MALIGNANCIES: A PEDIATRIC BRAIN TUMOR CONSORTIUM STUDY
INTRODUCTION: Telomerase activation is critical in many cancers including CNS tumors making telomerase inhibition a potential… 
2014
2014
Imetelstat (GRN163L), a Telomerase Inhibitor Selectively Affects Malignant Megakaryopoiesis in Myeloproliferative Neoplasms (MPN)
Imetelstat is a telomerase inhibitor which has been shown to have therapeutic activity in patients with myelofibrosis (MF… 
2010
2010
Anticancer activity of a broccoli derivative, sulforaphane, in barrett adenocarcinoma: potential use in chemoprevention and as adjuvant in chemotherapy.
2007
2007
The novel telomerase inhibitor GRN163L targets drug-resistant cancer stem cells in multiple myeloma
A97 The majority of chronic hematologic malignancies are responsive to initial treatment using standard agents, but most patients… 
2006
2006
Cancer Stem Cell Targeting in Multiple Myeloma by GRN163L, a Novel and Potent Telomerase Inhibitor.
Telomerase activity (TA) is required within normal cells capable of long-term replication, including stem cells and is… 
2005
2005
GRN163L Inhibits Telomerase Activity in B-CLL Cells.
B-CLL cells, like many solid and hematologic malignancies, are characterized by short telomeres, suggesting that they would be… 
2005
2005
Novel and potent telomerase antagonist (GRN163L) inhibits telomerase activity, resulting in telomere shortening and apoptosis of multiple myeloma cells
6605 In cancer cells, telomerase activity helps maintain telomere length, provide enhanced replicative potential and avoid… 
2005
2005
Preclinical efficacy, safety, and ADME of GRN163L, a novel telomerase inhibitor developed for the treatment of cancer
3168 Background: Telomerase maintains telomeric DNA and plays a critical role in tumor cell immortality. Human telomerase is… 
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