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Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase.
TLDR
The results demonstrate that the aggressive tumor behavior associated with a high-energy diet has similar effects on this signaling pathway and suggests a potential role for this agent in the management of a metabolically defined subset of colon cancers. Expand
Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
TLDR
It is predicted that any clinical utility of metformin or similar compounds in oncology will be restricted to subpopulations defined by host insulin levels and/or loss of function of LKB1, which can accelerate proliferation in contexts where it functions as a tumor suppressor. Expand
Metformin Reduces Endogenous Reactive Oxygen Species and Associated DNA Damage
TLDR
It is shown that metformin attenuates paraquat-induced elevations in reactive oxygen species (ROS), and related DNA damage and mutations, but has no effect on similar changes induced by H202, indicating a reduction in endogenous ROS production. Expand
Small Molecules, Inhibitors of DNA-PK, Targeting DNA Repair, and Beyond
Many current chemotherapies function by damaging genomic DNA in rapidly dividing cells ultimately leading to cell death. This therapeutic approach differentially targets cancer cells that generallyExpand
Differential expression of nm23 genes in adult mouse dorsal root ganglia
TLDR
Investigation of the expression of three NDPK isotypes in mouse dorsal root ganglia indicates a high expression of NDPK isoforms, not only in the central but also in the peripheral nervous system, and suggests that they have isoform‐specific roles in neuronal cell physiology. Expand
Chlorambucil Cytotoxicity in Malignant B Lymphocytes Is Synergistically Increased by 2-(Morpholin-4-yl)-benzo[h]chomen-4-one (NU7026)-Mediated Inhibition of DNA Double-Strand Break Repair via
TLDR
Results indicate that in a CLL cell line and in primary CLL-lymphocytes, chlorambucil plus NU7026 has synergistic cytotoxic activity at nontoxic doses of NU 7026, suggesting that the synergy of the combination is mediated by N U7026 inhibition of DNA-PK with subsequent inhibition of DSB repair. Expand
Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabine in vitro.
TLDR
The results suggest that dasatinib in combination with chlorambucil or fludarabine may improve the therapy of CLL. Expand
Effects of the novel DNA dependent protein kinase inhibitor, IC486241, on the DNA damage response to doxorubicin and cisplatin in breast cancer cells
TLDR
Improved cytotoxicity and significant synergy were observed with both anticancer agents in the presence of nontoxic concentrations of ICC and Enhanced efficacy of doxorubicin was achieved by inhibiting non-homologous end joining resulting in increased accumulation of DNA damage. Expand
Expression patterns of nm23 genes during mouse organogenesis
TLDR
In situ hybridization data has revealed the differential expression of nm23 mRNA during organogenesis, and the diverse NDPK isoforms are sequentially involved in various developmental processes. Expand
Characterization of the nm23-M2, nm23-M3 and nm23-M4 mouse genes: comparison with their human orthologs.
TLDR
The striking similarities between the human and mouse nm23 genes enable the use of mouse transgenic and knock-out models for studying the role of nucleoside diphosphate kinase isoforms in human physiopathology. Expand
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