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motesanib

An orally bioavailable receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular… 
National Institutes of Health

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Broader (1)

Imetelstat
NCIt Antineoplastic Agent TerminologyReceptor Tyrosine Kinase Inhibitionmotesanib diphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Molecular Pathways Associated with Aggressiveness of Papillary Thyroid Cancer
The most common thyroid malignancy is papillary thyroid cancer (PTC). Mortality rates from PTC mainly depend on its… 
2014
2014
Ab-initio and Conformational Analysis of a Potent VEGFR-2 Inhibitor: A Case Study on Motesanib
Vascular endothelial growth factor receptor-2 (VEGFR-2); a cell surface receptor for vascular endothelial growth factors, is a… 
Review
2012
Review
2012
Challenges in the current antiangiogenic treatment paradigm for patients with non-small cell lung cancer.
2011
2011
An international, randomized, placebo-controlled, double-blind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer…
LBA7512 The full, final text of this abstract will be available in Part II of the 2011 Annual Meeting Proceedings, distributed… 
Review
2010
Review
2010
Randomized, open-label phase II study of motesanib or bevacizumab in combination with paclitaxel and carboplatin (P/C) for advanced nonsquamous non-small cell lung cancer (NSCLC).
7528 Background: Motesanib is a small molecule antagonist of VEGF (1, 2, and 3), PDGF, and Kit receptors. The objective of this… 
2010
2010
Augmentation of Radiation Response by Motesanib, a Multikinase Inhibitor that Targets Vascular Endothelial Growth Factor Receptors
Background: Motesanib is a potent inhibitor of vascular endothelial growth factor receptors (VEGFR) 1, 2, and 3, platelet-derived… 
2010
2010
Motesanib with or without panitumumab (pmab) plus FOLFIRI or FOLFOX for the treatment of metastatic colorectal cancer (mCRC).
3538 Background: Motesanib is an oral inhibitor of VEGF, PDFG, and Kit receptors. Pmab, a fully human monoclonal antibody against… 
Highly Cited
2009
Highly Cited
2009
Targeting RET for thyroid cancer therapy.
Review
2009
Review
2009
Novel treatment of medullary thyroid cancer
Purpose of reviewMetastatic medullary thyroid cancer (MTC) is an incurable disease once metastasis becomes unresectable. Many… 
Review
2009
Review
2009
CIRG/TORI 010: 10-Month Analysis of a Randomized Phase II Trial of Motesanib Plus Weekly Paclitaxel as First Line Therapy in HER2-Negative Metastatic Breast Cancer (MBC).
Background: We assessed, in a double-blinded placebo-controlled trial, the effect of adding motesanib (M), a small molecule… 
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