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AMG 706

Known as: AMG-706, AMG706 
An orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Imetelstatmotesanib diphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation
Background/Aims: Vagus nerve stimulation (VNS) suppresses arrhythmic activity and minimizes cardiomyocyte injury. However, how… 
2018
2018
E4206: AMG 706 and Octreotide in Patients with Low‐Grade Neuroendocrine Tumors
Abstract Lessons Learned. Rate of progression‐free survival at a particular point in time, i.e., a landmark analysis, is a… 
2014
2014
Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.
2013
2013
Tumour markers fluctuations in patients with medullary thyroid carcinoma receiving long-term RET inhibitor therapy: ordinary lapping or alarming waves foreshadowing disease progression?
Medullary thyroid carcinoma (MTC), a rare malignancy arising from the parafollicular C cells of the thyroid gland, accounts for… 
Review
2012
Review
2012
The expanding role of somatostatin analogs in the management of neuroendocrine tumors.
BACKGROUND Neuroendocrine tumors (NETs) are neoplasms arising most often in the GI tract, pancreas, or lung. Diagnosis of NETs is… 
2009
2009
Motesanib diphosphate (AMG 706), an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma
[1] ten Bokkel Huinink W, Gore M, Carmichael J, Gordon A, Malfetano J, Hudson I, et al. Topotecan versus paclitaxel for the… 
2007
2007
Double resistance to imatinib and AMG 706 caused by multiple acquired KIT exon 17 mutations in a gastrointestinal stromal tumour
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms that arise in the wall of the gastrointestinal tract and… 
2006
2006
Safety and antitumor activity of AMG 706 in patients (pts) with thyroid cancer (TC): A subset analysis from a phase 1 dose-finding study.
3030 Background: AMG 706 is an investigational, oral, small molecule multi-kinase inhibitor with both antiangiogenic and direct… 
2006
2006
Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and gemcitabine/cisplatin (GC) for the treatment of advanced solid malignancies.
13005 Background: AMG 706 is an investigational, oral, multi-kinase inhibitor with both antiangiogenic and direct antitumor… 
2005
2005
The effect of AMG 706, a novel multi-kinase inhibitor, on vascular permeability and blood flow as assessed by dynamic contrast enhanced magnetic resonance imaging in an in vivo preclinical tumor…
3134 Background: AMG 706 is a potent, oral, multi-kinase inhibitor with anti-angiogenic and anti-tumor activity achieved by… 
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