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AMG 706

Known as: AMG-706, AMG706 
An orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits… 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Imetelstatmotesanib diphosphate

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
E4206: AMG 706 and Octreotide in Patients with Low‐Grade Neuroendocrine Tumors
Abstract Lessons Learned. Rate of progression‐free survival at a particular point in time, i.e., a landmark analysis, is a… 
2016
2016
Vascular endothelial growth factor receptor-2 (VEGFr-2) genetic polymorphisms as predictors to antiangiogenic therapy.
e14561 Background: Vascular endothelial growth factor (VEGF) and its receptors (VEGFr-2) have important roles in angiogenesis… 
2009
2009
Primary Analysis of a Phase 1b Combination Study of Motesanib (AMG 706) with Paclitaxel or Docetaxel for the Treatment of Locally Recurrent, Unresectable or Metastatic Breast Cancer.
Background: Motesanib is an oral inhibitor of VEGF receptors 1, 2 and 3; PDGF and Kit receptors that is under investigation as an… 
2007
2007
Double resistance to imatinib and AMG 706 caused by multiple acquired KIT exon 17 mutations in a gastrointestinal stromal tumour
Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms that arise in the wall of the gastrointestinal tract and… 
2006
2006
Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and gemcitabine/cisplatin (GC) for the treatment of advanced solid malignancies.
13005 Background: AMG 706 is an investigational, oral, multi-kinase inhibitor with both antiangiogenic and direct antitumor… 
2006
2006
[Therapeutic targets in gastrointestinal stromal tumors].
Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumors in the gastrointestinal tract, metastasize in up to… 
2006
2006
Solid forms and pharmaceutical compositions thereof Amg706
The present invention relates to a compound AMG706 of formula (I), in particular a solid form of the drug, pharmaceutical… 
2006
2006
Gateways to clinical trials.
Gateways to Clinical Trials are a guide to the most recent clinical trials in current literature and congresses. The data in the… 
2005
2005
The effect of AMG 706, a novel multi-kinase inhibitor, on vascular permeability and blood flow as assessed by dynamic contrast enhanced magnetic resonance imaging in an in vivo preclinical tumor…
3134 Background: AMG 706 is a potent, oral, multi-kinase inhibitor with anti-angiogenic and anti-tumor activity achieved by… 
2005
2005
Safety and pharmacokinetics of AMG 706 in patients with advanced solid tumors
3013 Introduction: AMG 706 is a potent, oral, multi-kinase inhibitor with anti-angiogenic and antitumor activity achieved by… 
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