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Purpose This phase III, randomized, placebo-controlled, double-blind study determined whether motesanib improved progression-free… Expand Cancer cells often become resistant to chemotherapy through a phenomenon known as multidrug resistance (MDR). Several factors are… Expand Medullary thyroid carcinoma (MTC), a rare malignancy arising from the parafollicular C cells of the thyroid gland, accounts for… Expand BACKGROUND
Neuroendocrine tumors (NETs) are neoplasms arising most often in the GI tract, pancreas, or lung. Diagnosis of NETs is… Expand  ten Bokkel Huinink W, Gore M, Carmichael J, Gordon A, Malfetano J, Hudson I, et al. Topotecan versus paclitaxel for the… Expand PURPOSE
AMG 706 is an investigational, orally bioavailable inhibitor of vascular endothelial growth factor receptors 1, 2, and 3… Expand The growth of solid tumors is dependent on the continued stimulation of endothelial cell proliferation and migration resulting in… Expand The epidermal growth factor receptor (EGFR) and its ligands figure prominently in the biology of gliomas, the most common tumors… Expand 7119 Introduction: AMG 706 is an investigational, oral, multi-kinase inhibitor with both antiangiogenic and direct antitumor… Expand 3030 Background: AMG 706 is an investigational, oral, small molecule multi-kinase inhibitor with both antiangiogenic and direct… Expand