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AMG 706
Known as:
AMG-706
, AMG706
An orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Imetelstat
motesanib diphosphate
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
VEGF-A and VEGF-B Coordinate the Arteriogenesis to Repair the Infarcted Heart with Vagus Nerve Stimulation
Yan-xia Lv
,
Sen Zhong
,
+17 authors
Jun-Ming Tang
Cellular Physiology and Biochemistry
2018
Corpus ID: 51677998
Background/Aims: Vagus nerve stimulation (VNS) suppresses arrhythmic activity and minimizes cardiomyocyte injury. However, how…
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2014
2014
Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1.
Yi-Jun Wang
,
Rishil J. Kathawala
,
+7 authors
Zhe-Sheng Chen
Biochemical pharmacology
2014
Corpus ID: 25566581
Review
2012
Review
2012
The expanding role of somatostatin analogs in the management of neuroendocrine tumors.
E. Wolin
Gastrointestinal cancer research : GCR
2012
Corpus ID: 42865288
BACKGROUND Neuroendocrine tumors (NETs) are neoplasms arising most often in the GI tract, pancreas, or lung. Diagnosis of NETs is…
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2009
2009
Motesanib diphosphate (AMG 706), an oral angiogenesis inhibitor, demonstrates clinical efficacy in advanced thymoma
A. Azad
,
R. Herbertson
,
D. Pook
,
S. White
,
P. Mitchell
,
N. Tebbutt
Acta oncologica
2009
Corpus ID: 27263657
[1] ten Bokkel Huinink W, Gore M, Carmichael J, Gordon A, Malfetano J, Hudson I, et al. Topotecan versus paclitaxel for the…
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Highly Cited
2007
Highly Cited
2007
Safety, pharmacokinetics, and efficacy of AMG 706, an oral multikinase inhibitor, in patients with advanced solid tumors.
L. Rosen
,
R. Kurzrock
,
+13 authors
R. Herbst
Journal of clinical oncology : official journal…
2007
Corpus ID: 41909548
PURPOSE AMG 706 is an investigational, orally bioavailable inhibitor of vascular endothelial growth factor receptors 1, 2, and 3…
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Review
2006
Review
2006
Epidermal Growth Factor Receptor–Mediated Signal Transduction in the Development and Therapy of Gliomas
M. Nicholas
,
R. Lukas
,
N. Jafri
,
L. Faoro
,
R. Salgia
Clinical Cancer Research
2006
Corpus ID: 10153656
The epidermal growth factor receptor (EGFR) and its ligands figure prominently in the biology of gliomas, the most common tumors…
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Highly Cited
2006
Highly Cited
2006
AMG 706, an oral, multikinase inhibitor that selectively targets vascular endothelial growth factor, platelet-derived growth factor, and kit receptors, potently inhibits angiogenesis and induces…
A. Polverino
,
A. Coxon
,
+19 authors
R. Kendall
Cancer research
2006
Corpus ID: 3183605
The growth of solid tumors is dependent on the continued stimulation of endothelial cell proliferation and migration resulting in…
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2006
2006
Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and carboplatin/paclitaxel (CP) for the treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC).
G. Blumenschein
,
A. Sandler
,
+7 authors
K. Reckamp
Journal of clinical oncology : official journal…
2006
Corpus ID: 12376013
7119 Introduction: AMG 706 is an investigational, oral, multi-kinase inhibitor with both antiangiogenic and direct antitumor…
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2006
2006
Safety and pharmacokinetics (PK) of AMG 706, panitumumab, and gemcitabine/cisplatin (GC) for the treatment of advanced solid malignancies.
J. Crawford
,
H. Burris III
,
+7 authors
L. Schwartzberg
Journal of clinical oncology : official journal…
2006
Corpus ID: 37313543
13005 Background: AMG 706 is an investigational, oral, multi-kinase inhibitor with both antiangiogenic and direct antitumor…
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2006
2006
Safety and antitumor activity of AMG 706 in patients (pts) with thyroid cancer (TC): A subset analysis from a phase 1 dose-finding study.
D. Boughton
,
L. Rosen
,
+7 authors
R. Herbst
Journal of clinical oncology : official journal…
2006
Corpus ID: 39847395
3030 Background: AMG 706 is an investigational, oral, small molecule multi-kinase inhibitor with both antiangiogenic and direct…
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