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IkappaB Kinase beta

Known as: IKK 2 Kinase, IKBKB, IKK beta 
National Institutes of Health

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4 relations
IKBKB geneIKBKB wt AlleleInhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta

Broader (1)

IkappaB kinase

Papers overview

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2017
2017
BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer…
PurposeWe previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic… 
2016
2016
A negative feedback loop between miR‐200b and the nuclear factor‐κB pathway via IKBKB/IKK‐β in breast cancer cells
MicroRNAs (miRNAs) act as important post‐transcriptional regulators of gene expression in diverse signalling pathways. However… 
2008
2008
Teratogen-induced distortions in the classical NF-kappaB activation pathway: correlation with the ability of embryos to survive teratogenic stress.
2007
2007
Artemisolide is a typical inhibitor of IkappaB kinase beta targeting cysteine-179 residue and down-regulates NF-kappaB-dependent TNF-alpha expression in LPS-activated macrophages.
Nuclear factor (NF)-kappaB regulates a central common signaling for immunity and cell survival. Artemisolide (ATM) was previously… 
2005
2005
Cyclin D1 induction through IkappaB kinase beta/nuclear factor-kappaB pathway is responsible for arsenite-induced increased cell cycle G1-S phase transition in human keratinocytes.
Environmental and occupational exposure to arsenite is associated with an increased risk of human cancers, including skin… 
2004
2004
IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation.
Dok1 is an abundant Ras-GTPase-activating protein-associated tyrosine kinase substrate that negatively regulates cell growth and… 
2004
2004
The FcepsilonRIbeta immunoreceptor tyrosine-based activation motif exerts inhibitory control on MAPK and IkappaB kinase phosphorylation and mast cell cytokine production.
The high affinity IgE Fc receptor (FcepsilonRI) beta chain functions as a signal amplifier and has been linked to atopy, asthma… 
2004
2004
Inhibition of ICAM-1 gene expression, monocyte adhesion and cancer cell invasion by targeting IKK complex: molecular and functional study of novel alpha-methylene-gamma-butyrolactone derivatives.
The transcription factor nuclear factor-kappaB (NF-kappaB) is a regulator related to cellular inflammation, immune responses and… 
Highly Cited
2002
Highly Cited
2002
Inhibition of Interleukin-1β-induced NF-κB Activation by Calcium/Calmodulin-dependent Protein Kinase Kinase Occurs through Akt Activation Associated with Interleukin-1 Receptor-associated Kinase…
Calcium/calmodulin-dependent protein kinase kinase (CaMKK) and Akt are two multifunctional kinases involved in many cellular… 
2002
2002
Role of Ca(2+) on TNF-alpha and IL-6 secretion from RBL-2H3 mast cells.
Ca2+ acts as an important second messenger in mast cells. However, the mechanisms involved in the secretion of inflammatory… 
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