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IKBKB wt Allele

Known as: IKK2, FLJ38368, FLJ33771 
Human IKBKB wild-type allele is located in the vicinity of 8p11.2 and is approximately 61 kb in length. This allele, which encodes inhibitor of… 
National Institutes of Health

Related topics

Related topics

19 relations
8p11.2Adipocytokine Signaling PathwayApoptosisB Cell Receptor Signaling Pathway

Broader (1)

IKBKB gene

Papers overview

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2011
2011
Hepatocyte IKK2 Protects Mdr2−/− Mice from Chronic Liver Failure
Mice lacking the Abc4 protein encoded by the multidrug resistance-2 gene (Mdr2 −/−) develop chronic periductular inflammation and… 
2011
2011
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl…
2010
2010
BI 5700, a Selective Chemical Inhibitor of IκB Kinase 2, Specifically Suppresses Epithelial-Mesenchymal Transition and Metastasis in Mouse Models of Tumor Progression.
Increasing evidence suggests that processes termed epithelial-mesenchymal transitions (EMTs) play a key role in therapeutic… 
2008
2008
Flt3 receptor inhibition reduces constitutive NFκB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia
High-risk myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are characterized by the activation of the anti… 
2008
2008
IκB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells
Chronic myelogenous leukemia is a malignant disease of the hematopoietic stem cell compartment, which is characterized by… 
2007
2007
AS602868, a dual inhibitor of IKK2 and FLT3 to target AML cells
Acute myeloid leukemia (AML) cells carry molecular defects that promote their leukemic proliferation, resistance to apoptosis and… 
2007
2007
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
IL-13 is a major Th2 cytokine that is capable of inducing inflammation, excessive mucus production, airway hyperresponsiveness… 
Highly Cited
2003
Highly Cited
2003
AS602868, a pharmacological inhibitor of IKK2, reveals the apoptotic potential of TNF-α in Jurkat leukemic cells
NF-κB transcription factors promote survival in numerous cell types via induction of antiapoptotic genes. Pharmacological… 
2003
2003
Molecular genetic analysis of human herpes virus 8-encoded viral FLICE inhibitory protein-induced NF-kappaB activation.
The human herpes virus 8 (HHV8)-encoded viral FLICE inhibitory protein (vFLIP), also known as K13, is known to activate the NF… 
Review
1998
Review
1998
Epstein – Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NFk B through a pathway that includes the NFk B-inducing kinase and the I k B kinases IKK…
The Epstein–Barr virus oncoprotein latent infection membrane protein 1 (LMP1) is a constitutively aggregated pseudo-tumor… 
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