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IKBKB wt Allele

Known as: IKK2, FLJ38368, FLJ33771 
Human IKBKB wild-type allele is located in the vicinity of 8p11.2 and is approximately 61 kb in length. This allele, which encodes inhibitor of… 
National Institutes of Health

Related topics

Related topics

19 relations
8p11.2Adipocytokine Signaling PathwayApoptosisB Cell Receptor Signaling Pathway

Broader (1)

IKBKB gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
BRCA1-mimetic compound NSC35446.HCl inhibits IKKB expression by reducing estrogen receptor-α occupancy in the IKKB promoter and inhibits NF-κB activity in antiestrogen-resistant human breast cancer…
PurposeWe previously identified small molecules that fit into a BRCA1-binding pocket within estrogen receptor-alpha (ERα), mimic… 
Review
2014
Review
2014
Bacterial safety of lettuce in primary production and fresh-cut processing industry
Fresh-cut or ready-to-eat produce including raw produce are becoming more popular due to changes in people’s lifestyle and… 
2011
2011
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
2011
2011
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl…
2008
2008
IκB kinase β inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ cells
Chronic myelogenous leukemia is a malignant disease of the hematopoietic stem cell compartment, which is characterized by… 
2008
2008
IkB kinase b (IKKb/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-kB
IKKb/IKBKB (IkB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkB molecules, the… 
2007
2007
Inhibition of NF-kappaB activation reduces the tissue effects of transgenic IL-13.
IL-13 is a major Th2 cytokine that is capable of inducing inflammation, excessive mucus production, airway hyperresponsiveness… 
2005
2005
Activation and function of hepatocyte NF-kappaB in postischemic liver injury.
The inhibitor of NF-kappaB (I-kappaB) kinase (IKK) complex consists of 3 subunits, IKK1, IKK2, and NF-kappaB essential modulator… 
2004
2004
Arresting NF-κB by β-arrestin2
Review
1998
Review
1998
Epstein – Barr virus-transforming protein latent infection membrane protein 1 activates transcription factor NFk B through a pathway that includes the NFk B-inducing kinase and the I k B kinases IKK…
The Epstein–Barr virus oncoprotein latent infection membrane protein 1 (LMP1) is a constitutively aggregated pseudo-tumor… 
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