IkappaB kinase

Known as: I-kappa B Kinase [Chemical/Ingredient], Inhibitor of Nuclear Factor Kappa-B Kinase, I-Kappa-B Kinase 
An enzyme complex that is involved in serine/threonine phosphorylation, inflammation and the regulation of the nuclear factor kappa-light-chain… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1972-2017
02040608019722017

Papers overview

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Highly Cited
2004
Highly Cited
2004
Apoptosis induced by p53 has been proposed to involve activation of the transcription factor NF-kappaB. Here we describe the… (More)
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Highly Cited
2003
Highly Cited
2003
The signal-inducible phosphorylation of serines 32 and 36 of I kappa B alpha is critical in regulating the subsequent… (More)
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Highly Cited
2002
Highly Cited
2002
NF-kappa B is usually activated by signal-induced, ubiquitin-mediated degradation of its inhibitor, I kappa B. This process is… (More)
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Highly Cited
2001
Highly Cited
2001
Signals emanating from the receptor for interleukin-1 (IL-1), lipopolysaccharide (LPS) or osteoclast differentiation factor… (More)
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Highly Cited
2001
Highly Cited
2001
Nuclear factor-kappaB (NF-kappaB)/Rel transcription factors regulate genes that control cell proliferation, survival, and… (More)
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Highly Cited
2000
Highly Cited
2000
Phosphorylation of IkappaB by the IkappaB kinase (IKK) complex is a critical step leading to IkappaB degradation and activation… (More)
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Highly Cited
2000
Highly Cited
2000
IKK gamma/NEMO is the essential regulatory subunit of the I kappa B kinase (IKK), encoded by an X-linked gene in mice and humans… (More)
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Highly Cited
1999
Highly Cited
1999
IkappaB [inhibitor of nuclear factor kappaB (NF-kappaB)] kinase (IKK) phosphorylates IkappaB inhibitory proteins, causing their… (More)
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Highly Cited
1999
Highly Cited
1999
The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and… (More)
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Highly Cited
1999
Highly Cited
1999
NF-kappa B plays a critical role in the transcriptional regulation of proinflammatory gene expression in various cells. Cytokine… (More)
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