Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta

Known as: IKK2, NFKBIKB, IKK-Beta 
Inhibitor of nuclear factor kappa-B kinase subunit beta (756 aa, ~87 kDa) is encoded by the human IKBKB gene. This protein is involved in serine… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Genetic mutations that give rise to active mutant forms of Ras are oncogenic and found in several types of tumor. However, such… (More)
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Highly Cited
2010
Highly Cited
2010
The transcription factor NF-kappaB is constitutively active in pancreatic adenocarcinoma. Here we explore the contribution of NF… (More)
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Review
2008
Review
2008
IKKbeta/IKBKB (IkappaB kinase beta), also designated as IKK2, was named after its function of phosphorylating IkappaB molecules… (More)
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Highly Cited
2008
Highly Cited
2008
S6K1 (p70S6K) is a serine kinase downstream from Akt in the insulin signaling pathway that is involved in negative feedback… (More)
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Highly Cited
2007
Highly Cited
2007
Activation of the inhibitor of NF-kappaB kinase/NF-kappaB (IKK/NF-kappaB) system and expression of proinflammatory mediators are… (More)
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Highly Cited
2006
Highly Cited
2006
This study explores the roles of genome copy number abnormalities (CNAs) in breast cancer pathophysiology by identifying… (More)
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Highly Cited
2003
Highly Cited
2003
The transcription factor NF-kappaB is implicated in various aspects of T cell development and function. The IkappaB kinase (IKK… (More)
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Highly Cited
2001
Highly Cited
2001
Activated hepatic stellate cells (HSCs) are the main producers of extracellular matrix in the fibrotic liver and contribute to… (More)
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Highly Cited
2000
Highly Cited
2000
The adapter protein RIP plays a crucial role in NF-kappaB activation by TNF. Here we show that triggering of the p55 TNF receptor… (More)
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Highly Cited
1999
Highly Cited
1999
IkappaB kinases (IKKs) IKK1 and IKK2 are two putative IkappaBalpha kinases involved in NF-kappaB activation. To examine the in… (More)
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