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IRF7 protein, human

Known as: IRF7, Interferon Regulatory Factor 7, IRF-7 
Interferon regulatory factor 7 (503 aa, ~54 kDa) is encoded by the human IRF7 gene. This protein plays a role in the cellular response to viral… 
National Institutes of Health

Related topics

Related topics

10 relations
Antiviral ResponseDNA-Binding ProteinsGenes, RegulatorIRF7 gene

Broader (1)

Interferon Regulatory Factor-7

Papers overview

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Highly Cited
2015
Highly Cited
2015
DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts
Highly Cited
2007
Highly Cited
2007
An Atomic Model of the Interferon-β Enhanceosome
Highly Cited
2005
Highly Cited
2005
IRF-7 is the master regulator of type-I interferon-dependent immune responses
The type-I interferon (IFN-α/β) response is critical to immunity against viruses and can be triggered in many cell types by… 
Highly Cited
2005
Highly Cited
2005
Spatiotemporal regulation of MyD88–IRF-7 signalling for robust type-I interferon induction
Robust type-I interferon (IFN-α/β) induction in plasmacytoid dendritic cells, through the activation of Toll-like receptor 9… 
Highly Cited
2004
Highly Cited
2004
Interferon-α induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
Toll-like receptors (TLRs) are involved in the recognition of microbial pathogens. A subset of TLRs, TLR7, TLR8 and TLR9, induces… 
Highly Cited
2004
Highly Cited
2004
Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.
Toll-like receptor (TLR) activation is central to immunity, wherein the activation of the TLR9 subfamily members TLR9 and TLR7… 
Highly Cited
2003
Highly Cited
2003
Triggering the Interferon Antiviral Response Through an IKK-Related Pathway
Rapid induction of type I interferon expression, a central event in establishing the innate antiviral response, requires… 
Highly Cited
2003
Highly Cited
2003
LPS-TLR4 Signaling to IRF-3/7 and NF-κB Involves the Toll Adapters TRAM and TRIF
Toll–IL-1–resistance (TIR) domain–containing adaptor-inducing IFN-β (TRIF)–related adaptor molecule (TRAM) is the fourth TIR… 
Highly Cited
2000
Highly Cited
2000
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
Induction of the interferon (IFN)-alpha/beta gene transcription in virus-infected cells is an event central to innate immunity… 
Highly Cited
1998
Highly Cited
1998
Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo.
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