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IRF7 protein, human

Known as: IRF7, Interferon Regulatory Factor 7, IRF-7 
Interferon regulatory factor 7 (503 aa, ~54 kDa) is encoded by the human IRF7 gene. This protein plays a role in the cellular response to viral… 
National Institutes of Health

Related topics

Related topics

10 relations
Antiviral ResponseDNA-Binding ProteinsGenes, RegulatorIRF7 gene

Broader (1)

Interferon Regulatory Factor-7

Papers overview

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Highly Cited
2009
Highly Cited
2009
Chloroquine Modulates HIV-1-Induced Plasmacytoid Dendritic Cell Alpha Interferon: Implication for T-Cell Activation
ABSTRACT Plasmacytoid dendritic cells (pDC) contribute to antiviral immunity mainly through recognition of microbial products and… 
Highly Cited
2007
Highly Cited
2007
Involvement of TBK1 and IKKϵ in lipopolysaccharide‐induced activation of the interferon response in primary human macrophages
Interferon (IFN) is an important effector of the innate immune response, induced by different viral or bacterial components… 
Highly Cited
2006
Highly Cited
2006
Induction of IRF-3 and IRF-7 phosphorylation following activation of the RIG-I pathway.
The induction of type I interferon (IFN) and the development of the innate antiviral response are mediated by the activation of… 
2006
2006
Promoter Organization of the Interferon-A Genes Differentially Affects Virus-induced Expression and Responsiveness to TBK1 and IKKϵ*
Virus-induced expression of interferon (IFN)-A genes is regulated by two members of the IFN regulatory factor (IRF) family, IRF-3… 
Highly Cited
2005
Highly Cited
2005
Hepatitis C virus inhibits intracellular interferon alpha expression in human hepatic cell lines
The chronicity of hepatitis C virus (HCV) infection raises the question of how HCV is able to persist in hepatic cells. We show… 
Highly Cited
2002
Highly Cited
2002
Regulation of DNA-Raised Immune Responses by Cotransfected Interferon Regulatory Factors
ABSTRACT Interferon regulatory factor 1 (IRF-1), IRF-3, and IRF-7 have been tested as genetic adjuvants for influenza virus… 
Highly Cited
2002
Highly Cited
2002
Cell-type and Donor-specific Transcriptional Responses to Interferon-α
A sensitive, specific, reproducible, robust, and cost-effective customized cDNA array system based on established nylon membrane… 
Highly Cited
2002
Highly Cited
2002
Regression of tumors by IFN-α electroporation gene therapy and analysis of the responsible genes by cDNA array
The key to success with nonviral gene therapy as a treatment for cancer is to discover effective therapeutic genes and gene… 
Review
2002
Review
2002
Regulation of virus-induced interferon-A genes.
2001
2001
The Cell Cycle Control Element of Histone H4 Gene Transcription Is Maximally Responsive to Interferon Regulatory Factor Pairs IRF-1/IRF-3 and IRF-1/IRF-7*
Interferon regulatory factors (IRFs) are transcriptional mediators of interferon-responsive signaling pathways that are involved… 
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