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IRF1 protein, human
Known as:
Interferon Regulatory Factor 1
, IRF-1
, interferon regulatory factor 1, human
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Interferon regulatory factor 1 (325 aa, ~37 kDa) is encoded by the human IRF1 gene. This protein plays a role in the regulation of interferon gene…
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National Institutes of Health
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Related topics
Related topics
11 relations
Apoptosis
DNA-Binding Proteins
Genes, Regulator
IRF1 gene
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Broader (1)
Interferon Regulatory Factor 1
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
IFN Regulatory Factor-1 Bypasses IFN-Mediated Antiviral Effects through Viperin Gene Induction
A. Stirnweiss
,
Antje Ksienzyk
,
+4 authors
A. Kröger
Journal of Immunology
2010
Corpus ID: 83918740
Viperin is an antiviral protein whose expression is highly upregulated during viral infections via IFN-dependent and/or IFN…
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Highly Cited
2008
Highly Cited
2008
The contribution of transcription factor IRF1 to the interferon-γ–interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
S. Kano
,
Kojiro Sato
,
+6 authors
T. Taniguchi
Nature Immunology
2008
Corpus ID: 7442254
Interleukin-12 (IL-12) and interferon-γ (IFN-γ) drive T helper type 1 (TH1) differentiation, but the mechanisms underlying the…
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Highly Cited
2002
Highly Cited
2002
Regulation of the IRF-1 tumour modifier during the response to genotoxic stress involves an ATM-dependent signalling pathway
J. Pamment
,
E. Ramsay
,
Michael O. Kelleher
,
D. Dornan
,
K. Ball
Oncogene
2002
Corpus ID: 17676135
The mechanism by which genotoxic stress induces IRF-1 and the signalling components upstream of this anti-oncogenic transcription…
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Highly Cited
2001
Highly Cited
2001
A Specific Interferon (IFN)-stimulated Response Element of the Distal HLA-G Promoter Binds IFN-regulatory Factor 1 and Mediates Enhancement of This Nonclassical Class I Gene by IFN-β*
S. Lefebvre
,
S. Berrih-Aknin
,
+6 authors
P. Paul
Journal of Biological Chemistry
2001
Corpus ID: 13285129
Type I interferons display a broad range of immunomodulatory functions. Interferon β increases gene expression at the…
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Highly Cited
2000
Highly Cited
2000
The IFN Regulatory Factor Family Participates in Regulation of Fas Ligand Gene Expression in T Cells
W. A. Chow
,
J. J. Fang
,
J. Yee
Journal of Immunology
2000
Corpus ID: 38033117
TCR engagement leads to the transcriptional activation of cytokine genes and activation-induced cell death. Activated T cells…
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Highly Cited
2000
Highly Cited
2000
Deficiency in the Transcription Factor Interferon Regulatory Factor (Irf)-2 Leads to Severely Compromised Development of Natural Killer and T Helper Type 1 Cells
M. Lohoff
,
G. Duncan
,
+7 authors
Tak W. Mak
Journal of Experimental Medicine
2000
Corpus ID: 11243806
Interferon (IFN) regulatory factor (IRF)-2 was originally described as an antagonist of IRF-1–mediated transcriptional regulation…
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Highly Cited
1998
Highly Cited
1998
Structure of IRF-1 with bound DNA reveals determinants of interferon regulation
C. Escalante
,
J. Yie
,
D. Thanos
,
A. Aggarwal
Nature
1998
Corpus ID: 4394514
The family of interferon regulatory factor (IRF) transcription factors is important in the regulation of interferons in response…
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Highly Cited
1998
Highly Cited
1998
Two families of GTPases dominate the complex cellular response to IFN-gamma.
Ulrich Boehm
,
L. Guethlein
,
+5 authors
Jonathan C. Howard
Journal of Immunology
1998
Corpus ID: 10501289
IFN-gamma induces a number of cellular programs functional in innate and adaptive resistance to infectious pathogens. It has…
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Highly Cited
1994
Highly Cited
1994
Suppression of c-myc or fosB-induced cell transformation by the transcription factor IRF-1.
N. Tanaka
,
M. Ishihara
,
T. Taniguchi
Cancer Letters
1994
Corpus ID: 31027950
Highly Cited
1990
Highly Cited
1990
Absence of the type I IFN system in EC cells: Transcriptional activator (IRF-1) and repressor (IRF-2) genes are developmentally regulated
H. Harada
,
K. Willison
,
J. Sakakibara
,
M. Miyamoto
,
T. Fujita
,
T. Taniguchi
Cell
1990
Corpus ID: 37124893
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