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Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.
TLDR
A previously unidentified pro-apoptotic gene, Noxa, which encodes a Bcl-2 homology 3 (BH3)-only member of the BCl-2 family of proteins may represent a mediator of p53-dependent apoptosis.
IRF family of transcription factors as regulators of host defense.
TLDR
Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis.
Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction.
TLDR
The results demonstrate the essential and distinct roles of the two factors, which together ensure the transcriptional efficiency and diversity of IFN-alpha/beta genes for the antiviral response.
TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo.
TLDR
The studies suggests that TAK1 acts as an upstream activating kinase for IKKbeta and JNK, but not IKKalpha, revealing an unexpectedly specific role of TAK 1 in inflammatory signaling pathways.
p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation
TLDR
The results suggest that a positive-feedback loop exists, whereby glycolysis drives IKK–NF-κB activation, and that hyperactivation of this loop by loss of p53 is important in oncogene-induced cell transformation.
Mechanism of p38 MAP kinase activation in vivo.
TLDR
It is shown that MKK3 and MKK6 are essential for tumor necrosis factor-stimulated p38 MAPK activation, and loss of p38MAPK activation in the mutant cells was associated with defects in growth arrest and increased tumorigenesis.
Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system.
TLDR
The DNA sequences recognized by IRf-1 and IRF-2 are determined, using a polymerase chain reaction-assisted DNA-binding site selection method, and it is reported that sequences selected by this method and the affinities for each sequence were virtually indistinguishable between IRF's 1 and 2.
Anti-oncogenic and oncogenic potentials of interferon regulatory factors-1 and -2
TLDR
When the IRF-2 gene was overexpressed in NIH 3T3 cells, the cells became transformed and displayed enhanced tumorigenicity in nude mice, and this transformed phenotype was reversed by concomitant overexpression of theIRF-1 gene.
Gene induction pathways mediated by distinct IRFs during viral infection.
TLDR
Using cells with a gene disruption for the IRF family of transcription factors, evidence is provided that these genes, containing similar IRF-binding cis-elements, are classified into distinct groups, based on the gene induction pathway(s).
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