INT 747

Known as: INT-747, INT747 
 
National Institutes of Health

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obeticholic acid

Papers overview

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Highly Cited
2014
Highly Cited
2014
Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats.
UNLABELLED The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and… (More)
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2013
2013
FXR Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats
AIMS Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated… (More)
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2012
2012
Testosterone and farnesoid X receptor agonist INT-747 counteract high fat diet-induced bladder alterations in a rabbit model of metabolic syndrome
In the male, metabolic syndrome (MetS) is associated to an increased risk of benign prostatic hyperplasia (BPH) and lower urinary… (More)
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Highly Cited
2012
Highly Cited
2012
Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit.
Metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) are often associated. One of… (More)
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Highly Cited
2011
Highly Cited
2011
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease.
BACKGROUND & AIMS Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from… (More)
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2011
2011
Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes.
INTRODUCTION The farnesoid X receptor (FXR) is critically involved in the regulation of the hepato-biliary system. Recent data… (More)
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Highly Cited
2010
Highly Cited
2010
Diabetic Nephropathy Is Accelerated by Farnesoid X Receptor Deficiency and Inhibited by Farnesoid X Receptor Activation in a Type 1 Diabetes Model
OBJECTIVE The pathogenesis of diabetic nephropathy is complex and involves activation of multiple pathways leading to kidney… (More)
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Highly Cited
2009
Highly Cited
2009
The bile acid receptor FXR is a modulator of intestinal innate immunity.
The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in enterohepatic tissues. In this study we… (More)
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Highly Cited
2009
Highly Cited
2009
Antiatherosclerotic effect of farnesoid X receptor.
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that functions as an endogenous sensor for bile… (More)
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Highly Cited
2004
Highly Cited
2004
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis.
The farnesoid X receptor (FXR), an endogenous sensor for bile acids, regulates a program of genes involved in bile acid… (More)
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