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INT 747

Known as: INT-747, INT747 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

obeticholic acid

Papers overview

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Highly Cited
2015
Highly Cited
2015
The FXR agonist obeticholic acid prevents gut barrier dysfunction and bacterial translocation in cholestatic rats.
Highly Cited
2014
Highly Cited
2014
Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats
The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal… 
Highly Cited
2012
Highly Cited
2012
Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit.
Metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) are often associated. One of… 
Highly Cited
2011
Highly Cited
2011
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
Background & aims Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation, resulting from… 
Review
2011
Review
2011
Non-Alcoholic Fatty Liver Disease: The Bile Acid-Activated Farnesoid X Receptor as an Emerging Treatment Target
  • M. Fuchs
  • Journal of Lipids
  • 2011
  • Corpus ID: 18711040
Non-alcoholic fatty liver disease (NAFLD) is currently evolving as the most common liver disease worldwide. It may progress to… 
2011
2011
FXR activation inhibits inflammation and preserves the intestinal barrier in IBD
Bile salts are produced in the liver and delivered to the duodenum, where they emulsify lipids to facilitate absorption. After… 
Highly Cited
2010
Highly Cited
2010
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist
Two dedicated receptors for bile acids (BAs) have been identified, the nuclear hormone receptor farnesoid X receptor (FXR) and… 
Highly Cited
2009
Highly Cited
2009
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity1
The farnesoid X receptor (FXR) is a bile acid-regulated nuclear receptor expressed in enterohepatic tissues. In this study we… 
Highly Cited
2009
Highly Cited
2009
Antiatherosclerotic effect of farnesoid X receptor.
The farnesoid X receptor (FXR) is a member of the nuclear receptor superfamily that functions as an endogenous sensor for bile… 
Highly Cited
2005
Highly Cited
2005
Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis
The farnesoid X receptor (FXR), an endogenous sensor for bile acids, regulates a program of genes involved in bile acid… 
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