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INT 747

Known as: INT-747, INT747 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

obeticholic acid

Papers overview

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2017
2017
Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on hepatic fibrosis
The farnesoid X receptor (FXR) agonist, a bile acid‐activated nuclear receptor, has been shown to improve the histologic features… 
2016
2016
Sweroside ameliorates α-naphthylisothiocyanate-induced cholestatic liver injury in mice by regulating bile acids and suppressing pro-inflammatory responses
Aim:Sweroside is an iridoid glycoside with diverse biological activities. In the present study we investigated the effects of… 
2013
2013
FXR Agonist INT-747 Upregulates DDAH Expression and Enhances Insulin Sensitivity in High-Salt Fed Dahl Rats
Aims Genetic and pharmacological studies have shown that impairment of the nitric oxide (NO) synthase (NOS) pathway is associated… 
Highly Cited
2012
Highly Cited
2012
Testosterone protects from metabolic syndrome-associated prostate inflammation: an experimental study in rabbit.
Metabolic syndrome (MetS) and benign prostatic hyperplasia (BPH)/lower urinary tract symptoms (LUTS) are often associated. One of… 
2011
2011
FXR activation inhibits inflammation and preserves the intestinal barrier in IBD
Bile salts are produced in the liver and delivered to the duodenum, where they emulsify lipids to facilitate absorption. After… 
Review
2011
Review
2011
Farnesoid X receptor activation improves erectile dysfunction in models of metabolic syndrome and diabetes.
Highly Cited
2011
Highly Cited
2011
Farnesoid X receptor activation improves erectile function in animal models of metabolic syndrome and diabetes.
INTRODUCTION The farnesoid X receptor (FXR) is critically involved in the regulation of the hepato-biliary system. Recent data… 
Highly Cited
2010
Highly Cited
2010
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist
Two dedicated receptors for bile acids (BAs) have been identified, the nuclear hormone receptor farnesoid X receptor (FXR) and… 
Highly Cited
2010
Highly Cited
2010
Farnesoid X Receptor Activation Prevents the Development of Vascular Calcification in ApoE−/− Mice With Chronic Kidney Disease
Rationale: Vascular calcification is highly associated with cardiovascular morbidity and mortality, especially in patients with… 
Highly Cited
2005
Highly Cited
2005
Protective Effects of 6-Ethyl Chenodeoxycholic Acid, a Farnesoid X Receptor Ligand, in Estrogen-Induced Cholestasis
The farnesoid X receptor (FXR), an endogenous sensor for bile acids, regulates a program of genes involved in bile acid… 
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