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obeticholic acid

Known as: 6-ethyl-3,7-dihydroxycholan-24-oic acid, 6-ethyl chenodeoxycholic acid, 6?-ethylchenodeoxycholic acid 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (1)

Chenodeoxycholic Acid

Narrower (1)

INT 747
analogs & derivativesobeticholic acid 5 MG Oral Tablet [Ocaliva]

Papers overview

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2018
2018
Structural optimization and in vitro profiling of N-phenylbenzamide-based farnesoid X receptor antagonists.
2018
2018
Discovery of new FXR agonists based on 6-ECDCA binding properties by virtual screening and molecular docking.
FXR is a member of the nuclear receptor superfamily, which regulates the expression of various genes involved in bile acid, lipid… 
Review
2018
Review
2018
The use of obeticholic acid for the management of non-viral liver disease: current clinical practice and future perspectives
ABSTRACT Introduction: Farnesoid X nuclear receptor is involved in the regulation of lipid and glucose metabolism, though mainly… 
2018
2018
The farnesoid X receptor agonist obeticholic acid upregulates biliary excretion of asymmetric dimethylarginine via MATE-1 during hepatic ischemia/reperfusion injury
Background We previously showed that increased asymmetric dimethylarginine (ADMA) biliary excretion occurs during hepatic… 
2018
2018
Occurrence of Jaundice Following Simultaneous Ursodeoxycholic Acid Cessation and Obeticholic Acid Initiation
Primary biliary cholangitis (PBC) is a chronic autoimmune cholestatic disease for which ursodeoxycholic acid (UDCA) has been the… 
2016
2016
Gene expression profiling in human precision-cut liver slices upon treatment with the FXR agonist obeticholic acid [human]
Background: The bile acid-activated farnesoid X receptor (FXR) is a nuclear receptor regulating bile acid, glucose and… 
2015
2015
Is obeticholic Acid the solution to nonalcoholic steatohepatitis?
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Although cardiovascular disease and… 
Review
2015
Review
2015
Recent advances in understanding/management of non-alcoholic steatohepatitis
Non-alcoholic steatohepatitis (NASH) can lead to advanced fibrosis, hepatocellular carcinoma, and end-stage liver disease… 
Review
2014
Review
2014
Therapeutic Role of Bile Acids and Nuclear Receptor Agonists in Fibrosing Cholangiopathies
Chronic inflammatory bile duct diseases such as primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) result… 
2011
2011
OP02 The first new monotherapy therapeutic PBC study in a decade? An international study evaluating the farnesoid X receptor agonist obeticholic acid in PBC
Introduction Obeticholic Acid (OCA), 6-ethyl chenodeoxycholic acid (CDCA) or INT-747, is a novel derivative of the primary human… 
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