obeticholic acid

Known as: 6-ethyl-3,7-dihydroxycholan-24-oic acid, 6-ethyl chenodeoxycholic acid, 6?-ethylchenodeoxycholic acid 
 
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
BACKGROUND Primary biliary cholangitis (formerly called primary biliary cirrhosis) can progress to cirrhosis and death despite… (More)
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2016
2016
Hepatic inflammation drives hepatic stellate cells (HSC), resulting in liver fibrosis. The Farnesoid-X receptor (FXR) antagonizes… (More)
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2016
2016
BACKGROUND & AIMS In advanced cirrhosis, gut bacterial translocation is the consequence of intestinal barrier disruption and… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The bile acid derivative 6-ethylchenodeoxycholic acid (obeticholic acid) is a potent activator of the farnesoid X… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND & AIMS We evaluated the efficacy and safety of obeticholic acid (OCA, α-ethylchenodeoxycholic acid) in a randomized… (More)
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2015
2015
BACKGROUND Bile acid diarrhoea is a common cause of chronic diarrhoea, occurring as a primary condition or secondary to ileal… (More)
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2015
2015
Bacterial translocation (BTL) drives pathogenesis and complications of cirrhosis. Farnesoid X-activated receptor (FXR) is a key… (More)
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Highly Cited
2014
Highly Cited
2014
UNLABELLED The farnesoid X receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and… (More)
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Highly Cited
2013
Highly Cited
2013
BACKGROUND & AIMS Obeticholic acid (OCA; INT-747, 6α-ethyl-chenodeoxycholic acid) is a semisynthetic derivative of the primary… (More)
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Highly Cited
2005
Highly Cited
2005
The farnesoid X receptor (FXR) is expressed by and regulates hepatic stellate cells (HSCs). In the present study, we investigated… (More)
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