The NAFLD fibrosis score: A noninvasive system that identifies liver fibrosis in patients with NAFLD
A simple scoring system accurately separates patients with nonalcoholic fatty liver disease with and without advanced fibrosis, rendering liver biopsy for identification ofAdvanced fibrosis unnecessary in a substantial proportion of patients.
Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome
The presence of multiple metabolic disorders is associated with a potentially progressive, severe liver disease and the increasing prevalence of obesity, coupled with diabetes, dyslipidemia, hypertension, and ultimately the metabolic syndrome puts a very large population at risk of forthcoming liver failure in the next decades.
Nonalcoholic fatty liver disease: a feature of the metabolic syndrome.
It is concluded that NAFLD, in the presence of normoglycemia and normal or moderately increased body weight, is characterized by clinical and laboratory data similar to those found in diabetes and obesity.
Association of nonalcoholic fatty liver disease with insulin resistance.
Prevalence of and risk factors for nonalcoholic fatty liver disease: The Dionysos nutrition and liver study
- G. Bedogni, L. Miglioli, F. Masutti, C. Tiribelli, G. Marchesini, S. Bellentani
- 1 July 2005
NAFLD is highly prevalent in the general population, is not associated with SLD, but is associated with many features of the metabolic syndrome.
Insulin resistance: A metabolic pathway to chronic liver disease
The ability of insulin‐sensitizing, pharmacological agents to treat NAFLD by reducing IR in the liver (metformin) and in the periphery (thiazolidinediones) are discussed.
A position statement on NAFLD/NASH based on the EASL 2009 special conference.
Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma.
Features suggestive of NASH are more frequently observed in HCC arising in patients with CC than in age- and sex-matched HCC patients of well-defined viral or alcoholic etiology.
Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
Normal ALT is not a valuable criterion to exclude patients from liver biopsy, and Alterations in glucose metabolism and insulin resistance in subjects with normal ALT should also be considered in the selection of NAFLD cases for histological assessment of disease severity and progression.