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Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells.
Endothelin (ET) 1 may act as a paracrine and autocrine factor for activated HSC and contribute to the increased resistance to portal flow in cirrhotic liver.
Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS).
Sexual health declined while concomitant morbidities increased in European men as a function of age, emphasizing the need to develop more effective strategies to promote healthy aging for men in transitional countries.
Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment.
A standardized process for diagnosis and treatment of Testosterone (T) deficiency is proposed, and the knowledge on T therapy (Tth) and prostate and cardiovascular safety is updated.
Summary of the recommendations on sexual dysfunctions in men.
Specific evaluation, treatment guidelines, and algorithms were developed for every sexual dysfunction in men, including erectile dysfunction; disorders of libido, orgasm, and ejaculation; Peyronie's disease; and priapism.
A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.
Testosterone and metabolic syndrome: a meta-analysis study.
A meta-analysis of the available cross-sectional data suggests that MetS can be considered an independent association of male hypogonadism and TRT seems to improve metabolic control, as well as central obesity.
Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia.
Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia.
Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study.
Lower testosterone and higher E(2) levels correlate with increased risk of CVD and CV mortality, and TRT in hypogonadism moderates metabolic components associated with CV risk.
Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane.
- M. Luconi, L. Bonaccorsi, E. Baldi
- Biology, ChemistryThe Journal of clinical endocrinology and…
- 1 March 1998
A significant correlation exists among affinity constants (as determined by binding studies) and EC50 values for the effects of P, 11betaOHP, and 17alphaOHP on intracellular Ca2+ in fura-2-loaded spermatozoa, strongly indicating the involvement of P-binding sites in the biological effect of the steroid.