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Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells.
TLDR
Endothelin (ET) 1 may act as a paracrine and autocrine factor for activated HSC and contribute to the increased resistance to portal flow in cirrhotic liver.
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Age-related changes in general and sexual health in middle-aged and older men: results from the European Male Ageing Study (EMAS).
TLDR
Sexual health declined while concomitant morbidities increased in European men as a function of age, emphasizing the need to develop more effective strategies to promote healthy aging for men in transitional countries.
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Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment.
TLDR
A standardized process for diagnosis and treatment of Testosterone (T) deficiency is proposed, and the knowledge on T therapy (Tth) and prostate and cardiovascular safety is updated.
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Summary of the recommendations on sexual dysfunctions in men.
TLDR
Specific evaluation, treatment guidelines, and algorithms were developed for every sexual dysfunction in men, including erectile dysfunction; disorders of libido, orgasm, and ejaculation; Peyronie's disease; and priapism.
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A systematic review and meta-analysis on the use of phosphodiesterase 5 inhibitors alone or in combination with α-blockers for lower urinary tract symptoms due to benign prostatic hyperplasia.
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Testosterone and metabolic syndrome: a meta-analysis study.
TLDR
A meta-analysis of the available cross-sectional data suggests that MetS can be considered an independent association of male hypogonadism and TRT seems to improve metabolic control, as well as central obesity.
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Seminal plasma cytokines and chemokines in prostate inflammation: interleukin 8 as a predictive biomarker in chronic prostatitis/chronic pelvic pain syndrome and benign prostatic hyperplasia.
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Critical analysis of the relationship between sexual dysfunctions and lower urinary tract symptoms due to benign prostatic hyperplasia.
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Hypogonadism as a risk factor for cardiovascular mortality in men: a meta-analytic study.
TLDR
Lower testosterone and higher E(2) levels correlate with increased risk of CVD and CV mortality, and TRT in hypogonadism moderates metabolic components associated with CV risk.
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Identification and characterization of functional nongenomic progesterone receptors on human sperm membrane.
TLDR
A significant correlation exists among affinity constants (as determined by binding studies) and EC50 values for the effects of P, 11betaOHP, and 17alphaOHP on intracellular Ca2+ in fura-2-loaded spermatozoa, strongly indicating the involvement of P-binding sites in the biological effect of the steroid.
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