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Loss of stearoyl–CoA desaturase-1 function protects mice against adiposity
TLDR
It is shown that mice with a targeted disruption of the SCD1 isoform have reduced body adiposity, increased insulin sensitivity, and are resistant to diet-induced weight gain, suggesting that a consequence ofSCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage.
Stearoyl-Coenzyme A Desaturase 1 Deficiency Protects against Hypertriglyceridemia and Increases Plasma High-Density Lipoprotein Cholesterol Induced by Liver X Receptor Activation
TLDR
It is suggested that SCD1 plays a pivotal role in the regulation of hepatic and plasma triglyceride accumulation, possibly by modulating the MUFA-to-SFA ratio.
Role for Stearoyl-CoA Desaturase-1 in Leptin-Mediated Weight Loss
TLDR
Ob/ob mice with mutations in SCD-1 were significantly less obese than ob/ob controls and had markedly increased energy expenditure, suggesting that down-regulation of SCD1 is an important component of leptin's metabolic actions.
Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver.
TLDR
The phosphorylation and activity of AMP-activated protein kinase (AMPK), a metabolic sensor that regulates lipid metabolism during increased energy expenditure is significantly increased and identified as a mediator of increased fatty acid oxidation in liver of SCD1-deficient mice.
A lipogenic diet in mice with a disruption of the stearoyl-CoA desaturase 1 gene reveals a stringent requirement of endogenous monounsaturated fatty acids for triglyceride synthesis.
TLDR
Observations demonstrate that induction of triglyceride synthesis is highly dependent on SCD1 gene expression.
Role of stearoyl-coenzyme A desaturase in lipid metabolism.
Relationship between stearoyl-CoA desaturase activity and plasma triglycerides in human and mouse hypertriglyceridemia Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200189-JLR200
TLDR
It is proposed that many of the factors that influence plasma triglyceride levels do so by converging upon the regulation of SCD activity and the desaturation index explains 44% of the variance in triglycerides.
Stearoyl-CoA Desaturase 1 Gene Expression Is Necessary for Fructose-mediated Induction of Lipogenic Gene Expression by Sterol Regulatory Element-binding Protein-1c-dependent and -independent
TLDR
It is demonstrated that oleate produced by SCD is necessary for fructose-mediated induction of lipogenic gene expression through SREBP-1c-dependent and -independent mechanisms and suggested that SCD1 gene expression is important in lipid and carbohydrate homeostasis.
Effects of diet and genetic background on sterol regulatory element-binding protein-1c, stearoyl-CoA desaturase 1, and the development of the metabolic syndrome.
TLDR
Dietary fat and genetic background act through SREBP-1c and SCD1 to affect hepatic lipid metabolism contributing to the development of the metabolic syndrome.
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