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IL2RG protein, human

Known as: Cytokine Receptor Common Subunit Gamma, Interleukin 2 Receptor Gamma, IL2RG 
Cytokine receptor common subunit gamma (369 aa, ~42 kDa) is encoded by the human IL2RG gene. This protein plays a role in both immune responses and… 
National Institutes of Health

Related topics

Related topics

19 relations
Cytokine Receptor GeneCytokine Signaling ProcessIL2 Signaling PathwayIL2RG gene

Broader (1)

Interleukin Receptor Common gamma Subunit

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2009
Review
2009
Functions of γC cytokines in immune homeostasis: current and potential clinical applications.
Highly Cited
2000
Highly Cited
2000
Janus kinase 3 (Jak3) is essential for common cytokine receptor gamma chain (gamma(c))-dependent signaling: comparative analysis of gamma(c), Jak3, and gamma(c) and Jak3 double-deficient mice.
The common cytokine receptor gamma chain (gamma(c)) is an essential receptor component for IL-2, IL-4, IL-7, IL-9 and IL-15, and… 
Highly Cited
1999
Highly Cited
1999
Restoration of lymphoid populations in a murine model of X-linked severe combined immunodeficiency by a gene-therapy approach.
X-linked severe combined immunodeficiency (XSCID) is a life-threatening syndrome in which both cellular and humoral immunity are… 
Highly Cited
1998
Highly Cited
1998
Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
Interleukin-2 (IL-2) induces heterodimerization of the IL-2 receptor beta (IL-2Rbeta) and gammac chains of its receptor and… 
Highly Cited
1998
Highly Cited
1998
γc Gene Transfer in the Presence of Stem Cell Factor, FLT-3L, Interleukin-7 (IL-7), IL-1, and IL-15 Cytokines Restores T-Cell Differentiation From γc(−) X-Linked Severe Combined Immunodeficiency…
X-linked severe combined immunodeficiency (SCID-Xl) is a rare human inherited disorder in which early T and natural killer (NK… 
Highly Cited
1997
Highly Cited
1997
Homodimerization of the human interleukin 4 receptor alpha chain induces Cepsilon germline transcripts in B cells in the absence of the interleukin 2 receptor gamma chain.
The cytokines interleukin (IL)-4 and IL-13 play a critical role in inducing Cepsilon germline transcripts and IgE isotype… 
Highly Cited
1997
Highly Cited
1997
Modulation of Interleukin (IL)-13 Binding and Signaling by the γc Chain of the IL-2 Receptor*
Interleukin (IL)-13 and IL-4 are cytokine products of TH2 cells which exert similar effects in a variety of cell types. We… 
Highly Cited
1996
Highly Cited
1996
Critical role for the common cytokine receptor gamma chain in intrathymic and peripheral T cell selection
The common cytokine receptor gamma chain (gammac), which is a functional subunit of the receptors for interleukins (IL)-2, -4, -7… 
Highly Cited
1991
Highly Cited
1991
Transformation by pp60src or stimulation of cells with epidermal growth factor induces the stable association of tyrosine-phosphorylated cellular proteins with GTPase-activating protein
GTPase-activating protein (GAP) is a cytosolic protein that stimulates the rate of hydrolysis of GTP (GTP to GDP) bound to normal… 
Highly Cited
1989
Highly Cited
1989
Identification of a novel fatty acylated protein that partitions between the plasma membrane and cytosol and is deacylated in response to serum and growth factor stimulation.
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