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Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
TLDR
Observations indicate that the functions of γc are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling. Expand
Development and characterization of IL-21–producing CD4+ T cells
TLDR
IL-21–producing CD4+ T cells exhibit distinct characteristics from Th17 cells and develop preferentially in an IL-6–rich environment devoid of TGF-β, and that IL-21 functions as an autocrine growth factor for IL–21– producing CD4- T cells is suggested. Expand
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
TLDR
A novel subset of natural killer T cells that expresses the interleukin 17 receptor B for IL-25 and is essential for the induction of AHR is identified, suggesting that IL-17RB+ CD4+ NKT cells play a crucial role in the pathogenesis of asthma. Expand
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.
TLDR
IL-23 and Th17 cells not only induce Th17-cell-mediated neutrophilic airway inflammation but also up-regulate Th2- cell-mediated eosinophil recruitment into the airways and airway hyperresponsiveness. Expand
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.
TLDR
An MDS mouse model is established by transducing a RUNX1S291fs mutant into hematopoietic stem cells and subsequently deleting Ezh2, providing a comprehensive picture of how Ezh 2 loss collaborates with RUNX 1 mutants in the pathogenesis of MDS in both cell autonomous and non-autonomous manners. Expand
Interleukin 21 prevents antigen-induced IgE production by inhibiting germ line C(epsilon) transcription of IL-4-stimulated B cells.
TLDR
IL-21 down-regulates IgE production from IL-4-stimulated B cells through the inhibition of germ line C(epsilon) transcription and thus suggest that IL-21 may be useful for the treatment of IgE-dependent allergic diseases. Expand
An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction.
TLDR
It is shown that Stat5a is essential for maximal responsiveness to antigenic stimuli in vivo, underscoring the physiological importance of IL-2-induced IL- 2R alpha expression. Expand
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by
TLDR
Both single locus and haplotype analyses suggest that polymorphisms within the MTHFR gene are associated with both the efficacy and toxicity of MTX in rheumatoid arthritis patients. Expand
IL-5 and eosinophilia.
TLDR
It is emphasized that IL-5 plays a pivotal role in the innate and acquired immune response and eosinophilia and the biologic effects of IL- 5 are best characterized for eOSinophils. Expand
IL-25 enhances allergic airway inflammation by amplifying a TH2 cell-dependent pathway in mice.
TLDR
The enforced expression of IL-25 in the lung itself failed to induce allergic airway inflammation, whereas the expression ofIL-25 significantly enhanced antigen-induced T(H)2 cytokine production, eosinophil and CD4(+) T cell recruitment, and goblet cell hyperplasia in the airways. Expand
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