Mutation of Jak3 in a Patient with SCID: Essential Role of Jak3 in Lymphoid Development
Observations indicate that the functions of γc are dependent on Jak3 and that Jak3 is essential for lymphoid development and signaling.
Development and characterization of IL-21–producing CD4+ T cells
IL-21–producing CD4+ T cells exhibit distinct characteristics from Th17 cells and develop preferentially in an IL-6–rich environment devoid of TGF-β, and that IL-21 functions as an autocrine growth factor for IL–21– producing CD4- T cells is suggested.
Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation.
An MDS mouse model is established by transducing a RUNX1S291fs mutant into hematopoietic stem cells and subsequently deleting Ezh2, providing a comprehensive picture of how Ezh 2 loss collaborates with RUNX 1 mutants in the pathogenesis of MDS in both cell autonomous and non-autonomous manners.
A novel subset of mouse NKT cells bearing the IL-17 receptor B responds to IL-25 and contributes to airway hyperreactivity
- Asuka Terashima, H. Watarai, M. Taniguchi
- Biology, ChemistryJournal of Experimental Medicine
- 24 November 2008
A novel subset of natural killer T cells that expresses the interleukin 17 receptor B for IL-25 and is essential for the induction of AHR is identified, suggesting that IL-17RB+ CD4+ NKT cells play a crucial role in the pathogenesis of asthma.
IL-23 and Th17 cells enhance Th2-cell-mediated eosinophilic airway inflammation in mice.
- H. Wakashin, K. Hirose, H. Nakajima
- Biology, MedicineAmerican Journal of Respiratory and Critical Care…
- 15 November 2008
IL-23 and Th17 cells not only induce Th17-cell-mediated neutrophilic airway inflammation but also up-regulate Th2- cell-mediated eosinophil recruitment into the airways and airway hyperresponsiveness.
Update on eosinophilic granulomatosis with polyangiitis.
Polymorphisms in the methylenetetrahydrofolate reductase gene were associated with both the efficacy and the toxicity of methotrexate used for the treatment of rheumatoid arthritis, as evidenced by…
Both single locus and haplotype analyses suggest that polymorphisms within the MTHFR gene are associated with both the efficacy and toxicity of MTX in rheumatoid arthritis patients.
Stat5b Is Essential for Natural Killer Cell–mediated Proliferation and Cytolytic Activity
An essential nonredundant role for Stat5b for potent NK cell–mediated proliferation and cytolytic activity is indicated for the immune system in Stat5-deficient mice.
IL-5 and eosinophilia.
Involvement of TNF Receptor-Associated Factor 6 in IL-25 Receptor Signaling1
Results indicate that TNFR-associated factor (TRAF)6 plays a critical role in IL-25R-mediated NF-κB activation and gene expression, and it is found that IL- 25R- mediated gene expression of IL-6, TGF-β, G-CSF, and thymus and activation-regulated chemokine was diminished in TRAF6-deficient murine embryonic fibroblast.