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IL2 Signaling Pathway

Known as: IL 2 signaling pathway 
Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 receptors are found on activated B-cells, LPS… 
National Institutes of Health

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CSNK2A1 wt AlleleELK1 wt AlleleFOS wt AlleleHRAS wt Allele

Papers overview

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1993
1993
Both the alpha and beta chains of high-affinity interleukin 2 receptors are located in intracellular vesicles when their ligand is endocytosed.
The growth factor interleukin 2 (IL2) binds to high and low-affinity receptors (Kd approximately 10-100 pM and 10 nM… 
1991
1991
Differential inhibition of interleukin 2‐ and interleukin 4‐mediated human B cell proliferation by ionomycin: A possible regulatory role for apoptosis
Surface immunoglobulin (Ig) cross‐linking by anti‐IgM (μ) antibodies leads to B cell activation resulting in numerous early… 
1988
1988
COMPARISON OF THE STRUCTURE OF THE MURINE INTERLEUKIN 2 (IL 2) RECEPTOR ON CYTOTOXIC AND HELPER T CELL LINES BY CHEMICAL CROSS‐LINKING OF 125I‐LABELED IL 2
The structure of the murine interleukin 2 receptor (IL2R), on a cytotoxic (CTLL) and a helper (HT2) cell line, has been studied… 
1987
1987
Identity of common phosphoprotein substrates stimulated by interleukin 2 and diacylglycerol suggests a role of protein kinase C for IL 2 signal transduction
Interleukin 2 (IL 2) is a polypeptide growth factor essential for the proliferation and differentiation of T lymphocytes, large… 
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