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IL2RA gene

Known as: IL2R, TAC ANTIGEN, CD25 
This gene plays a role in clathrin-independent endocytosis and immune functions.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25… Expand
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Highly Cited
2013
Highly Cited
2013
IL-2 receptor (IL-2R) signaling is essential for optimal stability and function of CD4+CD25hiFOXP3+ regulatory T cells (Treg); a… Expand
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Highly Cited
2012
Highly Cited
2012
Numerous reports have demonstrated that CD4+CD25+ regulatory T cells (Tregs) from individuals with a range of human autoimmune… Expand
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Highly Cited
2010
Highly Cited
2010
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS) comprising 6,333 affected individuals… Expand
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Highly Cited
2009
Highly Cited
2009
Genome-wide association studies (GWAS) have identified over 300 regions associated with more than 70 common diseases. However… Expand
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Highly Cited
2009
Highly Cited
2009
Multiple sclerosis (MS) and type 1 diabetes (T1D) are organ-specific autoimmune disorders with significant heritability, part of… Expand
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Highly Cited
2009
Highly Cited
2009
Variation in the genes encoding the interleukin (IL) 7 and IL2 receptor alpha chains (IL7RA, IL2RA) was recently found associated… Expand
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Highly Cited
2007
Highly Cited
2007
Genome-wide association studies are now identifying disease-associated chromosome regions. However, even after convincing… Expand
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Highly Cited
2007
Highly Cited
2007
A novel type 1 diabetes locus was mapped to the interleukin-2 receptor α gene (IL2RA) on chromosome 10p15.1, encoding an… Expand
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Highly Cited
2005
Highly Cited
2005
As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the… Expand
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