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The Cellular and Molecular Mechanisms of Immuno-Suppression by Human Type 1 Regulatory T Cells
The immuno-regulatory mechanisms of IL-10-producing type 1 regulatory T (Tr1) cells have been widely studied over the years. However, several recent discoveries have shed new light on the cellularExpand
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Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity
Cell-surface CD25 expression is critical for maintaining immune function and homeostasis. As in few reported cases, CD25 deficiency manifests with severe autoimmune enteritis and viral infections. ToExpand
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Insulin B chain 9–23 gene transfer to hepatocytes protects from type 1 diabetes by inducing Ag-specific FoxP3+ Tregs
Hepatocyte-targeted InsB9–23 gene transfer protects from type 1 diabetes by inducing antigen-specific regulatory T cells. Gene therapy for diabetes Gene therapy is being used with increasing successExpand
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Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk
Lentiviral vectors are attractive tools for liver‐directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, theExpand
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Identical β Cell-Specific CD8+ T Cell Clonotypes Typically Reside in Both Peripheral Blood Lymphocyte and Pancreatic Islets1
A major issue regarding T cell responses in autoimmunity is how the repertoire compares between the periphery and target organ. In type 1 diabetes, the status of at-risk or diabetic individuals canExpand
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Inducible Adeno-Associated Virus-Mediated IL-2 Gene Therapy Prevents Autoimmune Diabetes
IL-2 and TGF-β1 play key roles in the immunobiology of Foxp3-expressing CD25+CD4+ T cells (Foxp3+Treg). Administration of these cytokines offers an appealing approach to manipulate the Foxp3+TregExpand
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Immunotherapy for the Prevention and Treatment of Type 1 Diabetes
A major effort has been on-going to develop immunotherapies to prevent and/or treat type 1 diabetes (T1D). This autoimmune disease is characterized by the selective loss of the insulin-producing βExpand
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Adeno-associated virus vector-mediated IL-10 gene delivery prevents type 1 diabetes in NOD mice
The development of spontaneous autoimmune diabetes in nonobese diabetic (NOD) mice provides for their use as a model of human type 1 diabetes. To test the feasibility of muscle-directed gene therapyExpand
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Adeno-associated virus-mediated IL-10 gene therapy inhibits diabetes recurrence in syngeneic islet cell transplantation of NOD mice.
Islet transplantation represents a potential cure for type 1 diabetes, yet persistent autoimmune and allogeneic immunities currently limit its clinical efficacy. For alleviating the autoimmuneExpand
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Liver gene therapy by lentiviral vectors reverses anti-factor IX pre-existing immunity in haemophilic mice
A major complication of factor replacement therapy for haemophilia is the development of anti‐factor neutralizing antibodies (inhibitors). Here we show that liver gene therapy by lentiviral vectorsExpand
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