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IL2RA protein, human

Known as: IL2R, TAC Antigen, CD25 
Interleukin-2 receptor subunit alpha (272 aa, ~31 kDa) is encoded by the human IL2RA gene. This protein plays a role in interleukin-2-dependent… 
National Institutes of Health

Related topics

Related topics

25 relations

Broader (2)

Antigens, CD25Interleukin 2 Receptor, Alpha
ApoptosisB3(Fv)-PE38KDEL recombinant immunotoxinCell ProliferationCytokine Receptor Gene

Papers overview

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Highly Cited
1995
Highly Cited
1995
Distinct Functions of the FcεR1 γ and β Subunits in the Control of FcεR1-mediated Tyrosine Kinase Activation and Signaling Responses in RBL-2H3 Mast Cells (*)
In RBL-2H3 rat tumor mast cells, cross-linking the high affinity IgE receptor, FcεR1, activates the protein-tyrosine kinases Lyn… 
Highly Cited
1990
Highly Cited
1990
Characterization of murine lung dendritic cells: similarities to Langerhans cells and thymic dendritic cells
Dendritic cells (DC) are potent accessory cells (AC) for the initiation of primary immune responses. Although murine lymphoid DC… 
Highly Cited
1990
Highly Cited
1990
Thymosin alpha 1 modulates the expression of high affinity interleukin-2 receptors on normal human lymphocytes.
Review
1986
Review
1986
Human intestinal intraepithelial lymphocytes.
Of all the various cell types present within the lamina propria, it is remarkable that only lymphocytes predominantly gain access… 
Highly Cited
1986
Highly Cited
1986
Impairment of T cell activation in burn patients: a possible mechanism of thermal injury-induced immunosuppression.
In the burn patient, the mechanisms leading to impaired T lymphocyte activity are unclear. The capacity for T cell proliferation… 
Highly Cited
1985
Highly Cited
1985
Influence of the human T-lymphotropic virus/lymphadenopathy-associated virus on functions of human lymphocytes: evidence for immunosuppressive effects and polyclonal B-cell activation by banded viral…
The etiologic agent for the acquired immunodeficiency syndrome (AIDS) is now firmly established as the retrovirus termed the… 
Highly Cited
1985
Highly Cited
1985
Recombinant interleukin 2 enhanced natural killer cell-mediated cytotoxicity in human lymphocyte subpopulations expressing the Leu 7 and Leu 11 antigens.
Highly purified recombinant human interleukin 2 (rIL 2) markedly augments the natural killer (NK) cell-mediated cytotoxicity of… 
Highly Cited
1985
Highly Cited
1985
Regulatory role of a monomorphic determinant of HLA Class I antigens in T cell proliferation.
The role of HLA Class I antigens in T cell proliferation was investigated by using the anti-HLA Class I monoclonal antibodies… 
Highly Cited
1984
Highly Cited
1984
Stimulation of immunoglobulin secretion in human B lymphocytes as a direct effect of high concentrations of IL 2.
In certain human IgM and IgG cell lines, immunoglobulin (Ig) secretion is highly stimulated by a B cell inducing factor (BIF… 
Highly Cited
1982
Highly Cited
1982
Functional significance of Tac antigen expressed on activated human T lymphocytes: Tac antigen interacts with T cell growth factor in cellular proliferation.
Cultured human T cells (CTC), which are grown in conditioned medium containing T cell growth factor (TCGF), proliferate in… 
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