Interleukin 2 Receptor, Alpha

Known as: IL 2Ralpha, Interleukin-2Ralpha, CD25 Antigens 
A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA… (More)
National Institutes of Health

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12 relations

Broader (1)

Antigens, CD25
IL2RA geneIL2RA wt AlleleIn BloodInterleukin 2 Receptor
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Narrower (2)

IL2RA protein, humanInterleukin 2 Receptor, Alpha, Deficiency of

Papers overview

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Highly Cited
2010
Highly Cited
2010
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells.
Interleukin(IL)-2 and inflammation regulate effector and memory cytolytic T-lymphocyte (CTL) generation during infection. We… (More)
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Highly Cited
2007
Highly Cited
2007
Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7Rα–expressing cells
The common gamma chain cytokines interleukin (IL)-2 and IL-7 are important regulators of T cell homeostasis. Although IL-2 is… (More)
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Highly Cited
2007
Highly Cited
2007
The diagnostic significance of soluble CD163 and soluble interleukin-2 receptor alpha-chain in macrophage activation syndrome and untreated new-onset systemic juvenile idiopathic arthritis.
OBJECTIVE Macrophage activation syndrome is characterized by an overwhelming inflammatory reaction driven by excessive expansion… (More)
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Highly Cited
2005
Highly Cited
2005
Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
Interleukin-2 (IL-2) is an immunoregulatory cytokine that acts through a quaternary receptor signaling complex containing alpha… (More)
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Highly Cited
2001
Highly Cited
2001
Cutting edge: control of CD8+ T cell activation by CD4+CD25+ immunoregulatory cells.
CD4(+)CD25(+) regulatory T cells inhibit organ-specific autoimmune diseases induced by CD4(+)CD25(-) T cells and are potent… (More)
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Highly Cited
2001
Highly Cited
2001
The basis for IL-2-induced IL-2 receptor alpha chain gene regulation: importance of two widely separated IL-2 response elements.
The interleukin-2 receptor alpha (IL-2Ralpha) chain is an essential component of high-affinity IL-2 receptors. Accordingly, IL… (More)
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Highly Cited
2000
Highly Cited
2000
Daclizumab, a humanized anti-interleukin-2 receptor alpha chain antibody, for treatment of acute graft-versus-host disease.
Daclizumab, a humanized monoclonal IgG1 directed against the alpha chain of the interleukin-2 receptor (IL-2R), is a competitive… (More)
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Highly Cited
1999
Highly Cited
1999
Tumor rejection by in vivo administration of anti-CD25 (interleukin-2 receptor alpha) monoclonal antibody.
Immune regulation has been shown to be involved in the progressive growth of some murine tumors. In this study, we demonstrated… (More)
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Highly Cited
1997
Highly Cited
1997
Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor.
Profound cellular immunodeficiency occurs as the result of mutations in proteins involved in both the differentiation and… (More)
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Highly Cited
1988
Highly Cited
1988
HTLV-1 transactivator induces interleukin-2 receptor expression through an NF-kappa B-like factor.
Like other viruses that infect primate cells, the human T lymphotropic virus-I (HTLV-I) stimulates production of some host cell… (More)
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