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The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells
Thymic DC were surface positive for a number of markers characteristic of T cells, but they were distinct from T-lineage cells in expressing high levels of class II MHC, in lacking expression of the T cell receptor (TCR)-CD3 complex, and having TCR beta and gamma genes in germline state. Expand
NKT cells are phenotypically and functionally diverse
It is shown that NKT cells are phenotypically, functionally and developmentally heterogeneous, and that three distinct subsets (CD4+, DN and CD8+) are differentially distributed in a tissue‐specific fashion. Expand
The generation and fate of thymocytes.
In the adult thymus the majority of thymocytes are at a non-proliferating end stage, during which 3% of all CD4+CD8+ cortical thymocytes are selected on the basis of appropriate T-cellExpand
Thymus cell migration: Quantitative aspects of cellular traffic from the thymus to the periphery in mice
Intathymic injection of fluorescein isothiocyanate is used to label thymocytes in situ and so can be used to quantitate the extent of migration of cells from the thymus to the periphery. Expand
Regulation of TCR α and β gene allelic exclusion during T-cell development
The configuration and expression of T CR α and β genes in mature T-cell lines and TCR αβ transgenic mice are discussed and three nonexclusive models are proposed to account for the significant occurrence of T cells with two productive α gene rearrangements. Expand
Kinetics of mature T-cell development in the thymus.
The balance between cell birth, cell maturation, and cell death in the thymus is reexamined by labeling dividing thymocytes and their progeny in vivo with [3H], isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. Expand
Dynamics of Early T Cells: Prothymocyte Migration and Proliferation in the Adult Mouse Thymus
The object of this review has been to consider precursor cell migration into the normal adult thymus, using the mouse model, and to present a minimal model as a basis for further experiment. Expand
Recent thymic emigrants are distinct from most medullary thymocytes
The data indicate that export of cells from the medullary pool of SP thymocytes is not random, but that a series of maturational events within the SP stage are necessary before export can occur. Expand
Developmental potential of the earliest precursor cells from the adult mouse thymus
These findings indicate that this earliest intrathymic precursor population has become restricted (or strongly biased) to lymphoid lineage development, but not exclusively to T lymphocytes. Expand
Thrombopoietin, kit ligand, and flk2/flt3 ligand together induce increased numbers of primitive hematopoietic progenitors from human CD34+Thy-1+Lin- cells with preserved ability to engraft SCID-hu
Use of a combination of TPO, KL, and FL for short-term culture of CD34(+)Thy-1(+)Lin- cells increases the number of postdivision PHP, measured as CAFC, while preserving the capacity for in vivo engraftment. Expand