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IFNL4 gene

Known as: IFNAN, IFNL4, INTERFERON, LAMBDA-4 
This gene plays a role in antiviral responses and JAK-STAT pathway activation.
National Institutes of Health

Related topics

Related topics

5 relations
Antiviral ResponseCytokine Receptor BindingCytokine SignalingIFNL4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
IFNL4 Genotypes Predict Clearance of RNA Viruses in Rwandan Children With Upper Respiratory Tract Infections
Polymorphisms in the interferon lambda gene locus (IFNL) such as the IFNL4 genetic variants rs12979860 and rs368234815 are… 
2016
2016
Association with Spontaneous Hepatitis C Viral Clearance and Genetic Differentiation of IL28B/IFNL4 Haplotypes in Populations from Mexico
Aim To analyze the genetic heterogeneity of the Amerindian and admixed population (Mestizos) based on the IL28B (rs12979860… 
Highly Cited
2015
Highly Cited
2015
Hepatitis C Virus Reinfection and Spontaneous Clearance of Reinfection--the InC3 Study.
BACKGROUND We aimed to characterize the natural history of hepatitis C virus (HCV) reinfection and spontaneous clearance… 
Highly Cited
2014
Highly Cited
2014
Selection on a Variant Associated with Improved Viral Clearance Drives Local, Adaptive Pseudogenization of Interferon Lambda 4 (IFNL4)
Interferon lambda 4 gene (IFNL4) encodes IFN-λ4, a new member of the IFN-λ family with antiviral activity. In humans IFNL4 open… 
Review
2014
Review
2014
Role of IL28B for chronic hepatitis C treatment toward personalized medicine
Genome‐wide association studies recently revealed that certain interleukin‐28B (IL28B) polymorphisms are strongly associated with… 
2014
2014
Lymphocytes degranulation in liver in hepatitis C virus carriers is associated with IFNL4 polymorphisms and ALT levels.
BACKGROUND The polymorphisms of IFNL4 are strongly associated with both spontaneous hepatitis C virus (HCV) clearance and… 
2014
2014
IFNL4 ss469415590 variant is a better predictor than rs12979860 of pegylated interferon-alpha/ribavirin therapy failure in hepatitis C virus/HIV-1 coinfected patients
A new transiently induced region (interferon-&lgr; 4 protein; IFNL4) harbouring a dinucleotide variant ss469415590 (TT or &Dgr;G… 
2014
2014
Regulation of interferon lambda-1 (IFNL1/IFN-λ1/IL-29) expression in human colon epithelial cells.
2014
2014
Predictive value of the IFNL4 polymorphism on outcome of telaprevir, peginterferon, and ribavirin therapy for older patients with genotype 1b chronic hepatitis C
BackgroundOlder patients with chronic hepatitis C have a lower virological response to interferon (IFN) treatment compared to… 
2013
2013
HLA-DQB1*03 Confers Susceptibility to Chronic Hepatitis C in Japanese: A Genome-Wide Association Study
Hepatitis C virus (HCV) establishes a chronic infection in 70-80% of infected individuals. Many researchers have examined the… 
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