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IFNL4 gene

Known as: IFNAN, IFNL4, INTERFERON, LAMBDA-4 
This gene plays a role in antiviral responses and JAK-STAT pathway activation.
National Institutes of Health

Related topics

Related topics

5 relations
Antiviral ResponseCytokine Receptor BindingCytokine SignalingIFNL4 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Activation of Type I and Type III Interferons in Chronic Hepatitis C
Infection with hepatitis C virus (HCV) results in chronic and progressive liver disease. Persistency rates add up to 85%. Despite… 
2015
2015
The relationships between IFNL4 genotype, intrahepatic interferon‐stimulated gene expression and interferon treatment response differs in HCV‐1 compared with HCV‐3
The biological mechanism underlying the association between IFNL4/IFNL3 polymorphism and peginterferon/ribavirin (PR) response in… 
2015
2015
The Correlation between Hepatitis C Core Antigen and Hepatitis C Virus RNA Levels with Respect to Human Immunodeficiency Virus Status, Hepatitis C Virus Genotype and Interferon-Lambda-4 Polymorphism
Objectives: Serum hepatitis C virus (HCV) core antigen (HCVcAg) concentrations correlate with HCV RNA levels in HCV monoinfected… 
2015
2015
Relevance of low viral load in haemodialysed patients with chronic hepatitis C virus infection.
AIM To identify predictors of sustained virological response in hemodialysed patients treated by PEGinterferon α for chronic… 
2014
2014
Regulation of interferon lambda-1 (IFNL1/IFN-λ1/IL-29) expression in human colon epithelial cells.
2014
2014
Interferon lambda 4 polymorphism affects on outcome of telaprevir, pegylated interferon and ribavirin combination therapy for chronic hepatitis C
The predictive value of the recently identified interferon‐λ (IFNL)4 polymorphism on the outcome of telaprevir (TVR), pegylated… 
2014
2014
IFNL3 (IL28B) and IFNL4 polymorphisms are associated with treatment response in Thai patients infected with HCV genotype 1, but not with genotypes 3 and 6
Recent studies have shown an association between single nucleotide polymorphisms (SNPs) in the interferon lambda‐3 (IFNL3 or IL… 
2014
2014
The Impact of IFNL4 rs12979860 Polymorphism on Spontaneous Clearance of Hepatitis C; A Case-Control Study
Background: About 30% of individuals with hepatitis C virus (HCV) infection are able to clear HCV spontaneously. Differences in… 
2014
2014
IL28B Polymorphisms and Clinical Implications for Hepatitis C Virus Infection in Uzbekistan
Aims Genome-wide association studies highlighted single nucleotide polymorphisms (SNPs) within the IFNL3/IL28B locus predict the… 
2013
2013
Variation in IFNL4 genotype and response to interferon-based therapy of hepatitis C in HIV-positive patients with acute and chronic hepatitis C
The IFNL4 ss469415590 polymorphism has recently be shown to better predict treatment response in chronic hepatitis than the IL28B… 
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