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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
We report here the identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state. Three closely positioned genes on human chromosome 19 encodeExpand
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Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
Interleukin-10 (IL-10) is a pleiotropic cytokine with important immunoregulatory functions whose actions influence activities of many of the cell-types in the immune system. We report hereExpand
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Mapping of the human IL10 gene and further characterization of the 5’ flanking sequence
Abstract Interleukin-10 (IL-10) is an important regulatory cytokine whose involvement extends into diverse areas of the human immune system. Recent characterization of the promoter and 5’ flankingExpand
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A polymorphic dinucleotide repeat in the human IL-10 promoter
Interleukin-10 (IL-10) was originally defined as a cytokine able to alter the balance of mouse Thl and Th2 activity (Fiorentino et al. 1989). It has since been shown to have many roles, oftenExpand
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A second polymorphic dinucleotide repeat in the 5′ flanking region of the human IL10 gene
Interleukin-10 (IL10) is an important multifunctional cytokine, secreted by many cell types and to which a number of cell types are responsive (Moore 1992). IL-10 is steadily assuming a role as aExpand
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Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10
IL‐19 is a novel, recently identified member of the IL‐10 family of cytokines. We identified IL‐10 as a cytokine that was strongly induced in IL‐19‐stimulated PBMC. IL‐19‐induced IL‐10 secretion wasExpand
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Human interleukin-19 and its receptor: a potential role in the induction of Th2 responses.
Interleukin-19 (IL-19) is a newly discovered member of the IL-10 family of ligands whose function is presently undefined. We recently described its cloning and initial characterization and in soExpand
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Interleukin 10 (IL-10) influences autoimmune response in primary Sjögren's syndrome and is linked to IL-10 gene polymorphism.
OBJECTIVE To investigate the association between serum levels of interleukin 10 (IL-10), the synthesis of autoantibodies, salivary gland disease activity, clinical manifestations, and IL-10Expand
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Polymorphisms in the TNF gene cluster and MHC serotypes in the West of Scotland
Abstract We examined the distribution of polymorphic elements within the tumor necrosis factor (TNF) gene cluster in 105 unrelated individuals and determined their relationship to class I and classExpand
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Human β-Defensin 2 Induces a Vigorous Cytokine Response in Peripheral Blood Mononuclear Cells
ABSTRACT β-Defensins are a family of small cationic peptides involved in the innate response to microbial infection. Although their role in microbial killing is well established, the mechanismsExpand
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