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IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex.
TLDR
The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs. Expand
IFN-λs mediate antiviral protection through a distinct class II cytokine receptor complex
TLDR
The identification of a ligand-receptor system that, upon engagement, leads to the establishment of an antiviral state and may contribute to antiviral or other defenses by a mechanism similar to, but independent of, type I IFNs. Expand
Cytokine gene polymorphism in human disease: on-line databases
TLDR
A review of the findings of these studies presented shows that interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Expand
Cloning, expression and initial characterisation of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)
Interleukin-10 (IL-10) is a pleiotropic cytokine with important immunoregulatory functions whose actions influence activities of many of the cell-types in the immune system. We report hereExpand
Interleukin 10 secretion in relation to human IL-10 locus haplotypes.
TLDR
The ability to secrete interleukin 10 can vary in man according to the genetic composition of the IL-10 locus, and it is shown that the haplotype IL10.R2/IL10.G14 was associated with highestIL-10 secretion overall, whereas the haplotypes containing the allele IL 10.R3/IL11.R were associated with lowest IL- 10 secretion. Expand
Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus.
TLDR
The results show that there is an allelic imbalance between SLE patients and controls at the IL10.G microsatellite, and suggest that the IL-10 locus contributes to the genetic background important for the development of this disease. Expand
Mapping of the human IL10 gene and further characterization of the 5’ flanking sequence
TLDR
The mapping of the human IL10 gene to a discrete area of chromosome 1 is described, the definition of a potential cytokine-responsive segment 3 – 4 kilobases upstream of the transcription initiation site, and the identification of two new point mutations in the immediate promoter region with their distribution in a panel of 75 unrelated healthy individuals are described. Expand
A polymorphic dinucleotide repeat in the human IL-10 promoter
TLDR
A DNA sequence corresponding to the promoter and first exon of human IL-10 was recently deposited in the GenEMBL database and showed the presence of a CA repeat, approximately 1064 base pairs (bp) upstream of the proposed TATA box, which was examined for evidence of polymorphism. Expand
Human IL‐19 regulates immunity through auto‐induction of IL‐19 and production of IL‐10
TLDR
The results advance the understanding of the function of this novel cytokine and its regulation within the human immune system, in addition to providing a new insight into the control of the important immunoregulatory cytokine, IL‐10. Expand
A second polymorphic dinucleotide repeat in the 5′ flanking region of the human IL10 gene
TLDR
The potential importance of IL-10 in the epidemiology of autoimmune diseases and lymphoid malignancies has led us to search for polymorphic elements within the IL10 locus, which may provide insights into this cytokine’s involvement in genetic predisposition in human disease. Expand
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