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Interleukin‐29 uses a type 1 interferon‐like program to promote antiviral responses in human hepatocytes
TLDR
IL‐29 and IFN‐α stimulate identical antiviral responses despite their utilization of different receptors, which suggests that IL‐29 may have therapeutic value against chronic viral hepatitis in human patients. Expand
Functions of glutathione and glutathione disulfide in immunology and immunopathology
TLDR
It is proposed that the well‐known immunological consequences of GSH depletion ultimately may be results of the accompanying GSSG deficiency, and hypothesize that AIDS may be the consequence of a G SSG deficiency as well. Expand
Modulation of transcription factor NF kappa B activity by intracellular glutathione levels and by variations of the extracellular cysteine supply.
TLDR
It is shown that a depletion of intracellular glutathione in a human T cell line (Molt-4) inhibits the activation and nuclear translocation of the transcription factor NF kappa B, whereas incubation with increasing extracellular concentrations of cysteine inhibits the DNA-binding and transactivating activity of NF k Kappa B. Expand
Diet high in fructose leads to an overexpression of lipocalin-2 in rat fatty liver.
TLDR
Fructose diet up-regulates hepatic LCN-2 expression, which correlates with the increased indicators of oxidative stress and mitochondrial dysfunction, and may be involved in liver protection. Expand
Distinct effects of glutathione disulphide on the nuclear transcription factor kappa B and the activator protein-1.
TLDR
It is shown that both the activation of NF kappa B and the inhibition of its DNA binding activity is modulated in intact cells by the physiological oxidant glutathione disulphide (GSSG), and a shift of redox conditions may support optimal oxidative activation with minimal inhibition of DNA binding. Expand
Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype
TLDR
The data support the hypothesis that distinct genotypes of HCV appear to be associated with distinct manifestations of disease and suggest interrelationships between virus genotype, patient's age, and a history of intravenous drug abuse. Expand
HIV-induced cysteine deficiency and T-cell dysfunction--a rationale for treatment with N-acetylcysteine.
TLDR
The intact immune system appears to require a delicate balance between pro-oxidant and antioxidant conditions, maintained by a limited and well-regulated supply of cysteine, which is obviously disturbed in HIV infection and may contribute to the pathogenesis of AIDS. Expand
Interferon‐γ inhibits replication of subgenomic and genomic hepatitis C virus RNAs
TLDR
It is suggested that cytotoxic T cells and natural killer cells may contribute to HCV clearance not only by cell killing but also by producing IFN‐γ, thereby enhancing the intracellular inhibition of viral replication. Expand
Modulation of lymphocyte functions and immune responses by cysteine and cysteine derivatives.
TLDR
The more detailed analysis revealed that the extracellular supply of cysteine influences strongly the intracellular level of glutathione and also the activity of the transcription factor NF kappa B that regulates the expression of several immunologically relevant genes. Expand
Toll‐like receptor 7 rs179008/Gln11Leu gene variants in chronic hepatitis C virus infection
TLDR
Analysis of epidemiological and clinical data from 136 patients with HCV infection with regard to rs179008/Gln11Leu, a non‐synonymous polymorphism within exon 3 of the X‐linked TLR7 gene, found the variant allele of which is suggested to code for a functionally impaired protein to have implications for responsiveness to future IFN‐λ‐based approaches. Expand
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