IEM 1754

The action of non-competitive glutamate receptor antagonists on the effects of sleep deprivation has been studied on Krushinskii… (More)

The action of noncompetitive blockers of glutamate receptors has been investigated on Krushinski-Molodkina rats genetically-prone… (More)

There is numerous experimental and conceptual proof that the extracellular portion of ionotropic glutamate receptors (iGluRs), i… (More)

The action of three dicationic drugs, derivatives of adamantane (IEM-1460 and IEM-1754) and phencyclidine (IEM-1925), on… (More)

1. The kinetics of open channel block of GluR2-containing and GluR2-lacking AMPA receptors (AMPAR) by dicationic compounds (IEM… (More)

Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker… (More)

We report the presence of binding sites for permeant monovalent cations at the internal and external entrances to the channel of… (More)

1. The effects of two adamantane derivatives, 1-trimethylammonio-5-(1-adamantane-methyl-ammoniopentane dibromide) (IEM-1460) and… (More)

1. The mechanisms by which four adamantane derivatives (IEM-1857, -1592, -1460 and -1754) block the open NMDA-activated channel… (More)

We examined the influence of the molecular structure of four novel adamantane derivatives on their ability to block the channels… (More)