IEM 1754

Experiments on Krushinskii–Molodkina rats, with an inherited predisposition to audiogenic seizures, addressed the actions of a… Expand

There is numerous experimental and conceptual proof that the extracellular portion of ionotropic glutamate receptors (iGluRs), i… Expand

Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5–3.0 mg/kg decreased the… Expand

The action of three dicationic drugs, derivatives of adamantane (IEM-1460 and IEM-1754) and phencyclidine (IEM-1925), on… Expand

The kinetics of open channel block of GluR2‐containing and GluR2‐lacking AMPA receptors (AMPAR) by dicationic compounds (IEM‐1460… Expand

Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker… Expand

We report the presence of binding sites for permeant monovalent cations at the internal and external entrances to the channel of… Expand

1 The effects of two adamantane derivatives, 1‐trimethylammonio‐5‐(l‐adamantane‐methylammoniopentane dibromide) (IEM‐1460) and 1… Expand

1. The mechanisms by which four adamantane derivatives (IEM‐1857, ‐1592, ‐1460 and ‐1754) block the open NMDA‐activated channel… Expand

We examined the influence of the molecular structure of four novel adamantane derivatives on their ability to block the channels… Expand