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IEM 1754

Known as: IEM-1754 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AdamantaneQuaternary Ammonium Compounds
analogs & derivatives

Papers overview

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2013
2013
[The action of ionotropic glutamate receptor channel blockers on effects of sleep deprivation in rats].
The action of non-competitive glutamate receptor antagonists on the effects of sleep deprivation has been studied on Krushinskii… 
2008
2008
Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor.
There is numerous experimental and conceptual proof that the extracellular portion of ionotropic glutamate receptors (iGluRs), i… 
2007
2007
Combined blockade of α3β4 nicotinic acetylcholine receptors and GluR1 AMPA receptors in rats prevents kainate-induced tonic-clonic seizures
Intramuscular injection of IEM-1754, a blocker of cerebral GluR1 AMPA receptors, in doses of 0.5–3.0 mg/kg decreased the… 
2000
2000
Voltage‐dependent block of native AMPA receptor channels by dicationic compounds
The kinetics of open channel block of GluR2‐containing and GluR2‐lacking AMPA receptors (AMPAR) by dicationic compounds (IEM‐1460… 
2000
2000
[A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats].
Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker… 
2000
2000
[The search for selective blockers of NMDA and AMPA/kainate receptors in a series of bis-ammonium compounds with adamantyl radicals].
Two groups of substances capable of selectively blocking the NMDA and AMPA/kainate receptors in experiments on intact animals… 
2000
2000
[Bis-ammonium adamantane derivatives--novel modulators of polyamine binding sites].
Experiments on intact rats and mice showed that the polyamine agonist spermine and the bis-ammonium adamantyl-containing… 
Highly Cited
1998
Highly Cited
1998
Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block
We report the presence of binding sites for permeant monovalent cations at the internal and external entrances to the channel of… 
1997
1997
Channel blocking drugs as tools to study glutamate receptors in insect muscles and molluscan neurons
The action of three dicationic drugs, derivatives of adamantane (IEM-1460 and IEM-1754) and phencyclidine (IEM-1925), on… 
Highly Cited
1995
Highly Cited
1995
Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants.
We examined the influence of the molecular structure of four novel adamantane derivatives on their ability to block the channels… 
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