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IEM 1754

Known as: IEM-1754 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AdamantaneQuaternary Ammonium Compounds
analogs & derivatives

Papers overview

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2013
2013
Effects of Ionotropic Glutamate Channel Blockers on Audiogenic Seizure Reactions in Krushinskii–Molodkina Rats
Experiments on Krushinskii–Molodkina rats, with an inherited predisposition to audiogenic seizures, addressed the actions of a… 
2008
2008
Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor.
There is numerous experimental and conceptual proof that the extracellular portion of ionotropic glutamate receptors (iGluRs), i… 
2006
2006
Channel blocking drugs as tools to study glutamate receptors in insect muscles and molluscan neurons
The action of three dicationic drugs, derivatives of adamantane (IEM-1460 and IEM-1754) and phencyclidine (IEM-1925), on… 
2000
2000
Voltage‐dependent block of native AMPA receptor channels by dicationic compounds
The kinetics of open channel block of GluR2‐containing and GluR2‐lacking AMPA receptors (AMPAR) by dicationic compounds (IEM‐1460… 
2000
2000
[A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats].
Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker… 
2000
2000
[The search for selective blockers of NMDA and AMPA/kainate receptors in a series of bis-ammonium compounds with adamantyl radicals].
Two groups of substances capable of selectively blocking the NMDA and AMPA/kainate receptors in experiments on intact animals… 
Highly Cited
1998
Highly Cited
1998
Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block
We report the presence of binding sites for permeant monovalent cations at the internal and external entrances to the channel of… 
Highly Cited
1997
Highly Cited
1997
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by Adamantane derivatives
1 The effects of two adamantane derivatives, 1‐trimethylammonio‐5‐(l‐adamantane‐methylammoniopentane dibromide) (IEM‐1460) and 1… 
Highly Cited
1996
Highly Cited
1996
Voltage‐dependent interaction of open‐channel blocking molecules with gating of NMDA receptors in rat cortical neurons.
1. The mechanisms by which four adamantane derivatives (IEM‐1857, ‐1592, ‐1460 and ‐1754) block the open NMDA‐activated channel… 
Highly Cited
1995
Highly Cited
1995
Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants.
We examined the influence of the molecular structure of four novel adamantane derivatives on their ability to block the channels… 
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