IEM 1754

Known as: IEM-1754 
 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (2)

AdamantaneQuaternary Ammonium Compounds
analogs & derivatives

Papers overview

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2008
2008
Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor.
There is numerous experimental and conceptual proof that the extracellular portion of ionotropic glutamate receptors (iGluRs), i… Expand
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2000
2000
Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
1. The kinetics of open channel block of GluR2-containing and GluR2-lacking AMPA receptors (AMPAR) by dicationic compounds (IEM… Expand
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2000
2000
[A comparative study of the central H-cholinergic-blocking and NMDA-blocking actions of MK-801, memantin, amantadine, pyrilen and IEM-1754 in experiments on intact rats].
Pyrilene acts as a central H-cholinoblocker upon intramuscular injection at a dose of 0.02-0.08 mg/kg, and as an NMDA-blocker… Expand
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2000
2000
[Glutamate receptor antagonists attenuate experimental catalepsy in rats].
A long-term akinesia induced by haloperidol used as an experimental model of catalepsy helped to reveal that a dicationic… Expand
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2000
2000
[The search for selective blockers of NMDA and AMPA/kainate receptors in a series of bis-ammonium compounds with adamantyl radicals].
Two groups of substances capable of selectively blocking the NMDA and AMPA/kainate receptors in experiments on intact animals… Expand
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1998
1998
Binding sites for permeant ions in the channel of NMDA receptors and their effects on channel block
We report the presence of binding sites for permeant monovalent cations at the internal and external entrances to the channel of… Expand
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Highly Cited
1997
Highly Cited
1997
Block of open channels of recombinant AMPA receptors and native AMPA/kainate receptors by adamantane derivatives.
1. The effects of two adamantane derivatives, 1-trimethylammonio-5-(1-adamantane-methyl-ammoniopentane dibromide) (IEM-1460) and… Expand
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1997
1997
Channel blocking drugs as tools to study glutamate receptors in insect muscles and molluscan neurons
The action of three dicationic drugs, derivatives of adamantane (IEM-1460 and IEM-1754) and phencyclidine (IEM-1925), on… Expand
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1996
1996
Voltage-dependent interaction of open-channel blocking molecules with gating of NMDA receptors in rat cortical neurons.
1. The mechanisms by which four adamantane derivatives (IEM-1857, -1592, -1460 and -1754) block the open NMDA-activated channel… Expand
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1995
1995
Novel adamantane derivatives act as blockers of open ligand-gated channels and as anticonvulsants.
We examined the influence of the molecular structure of four novel adamantane derivatives on their ability to block the channels… Expand
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