ICI 207968

Inflammatory mediators have been implicated in the pathophysiology of ulcerative colitis. They may stimulate intestinal secretion… (More)

1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2… (More)

Metabolites of arachidonic acid have been implicated in the pathophysiology of ulcerative colitis-they can stimulate intestinal… (More)

Since the hypothetical mechanisms of hydroperoxydation of arachidonic acid by, respectively, 5-lipoxygenase (5-LPO) and… (More)

TNF is a potent cytokine which can induce many of the pathological changes associated with inflammatory disease.In vitro studies… (More)

1. This paper describes the pharmacological profile of ICI207968, a novel, orally-active and selective inhibitor of 5… (More)

The objective of this work was to investigate the role of leukotrienes in the production of IL-1 by activated human peripheral… (More)