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ICI 207968

Known as: ICI-207968, ICI207968 
National Institutes of Health

Papers overview

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2005
2005
Tumour necrosis factor production in a rat airpouch model of inflammation: Role of eicosanoids
TNF is a potent cytokine which can induce many of the pathological changes associated with inflammatory disease.In vitro studies… 
1994
1994
Potential role for interleukin-1 in the pathophysiology of ulcerative colitis.
1. Biopsies of colonic mucosa from patients with ulcerative colitis liberated more interleukin-1 beta, prostaglandin E2… 
Highly Cited
1993
Highly Cited
1993
Inter-relationships between inflammatory mediators released from colonic mucosa in ulcerative colitis and their effects on colonic secretion.
Metabolites of arachidonic acid have been implicated in the pathophysiology of ulcerative colitis-they can stimulate intestinal… 
1990
1990
2‐Substituted indazolinones: orally active and selective 5‐lipoxygenase inhibitors with anti‐inflammatory activity
1 This paper describes the pharmacological profile of ICI207968, a novel, orally‐active and selective inhibitor of 5‐lipoxygenase… 
1990
1990
Leukotrienes do not regulate interleukin 1 production by activated macrophages.
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