Leukotrienes do not regulate interleukin 1 production by activated macrophages.

@article{Parkar1990LeukotrienesDN,
  title={Leukotrienes do not regulate interleukin 1 production by activated macrophages.},
  author={B. A. Parkar and M. McCormick and S. J. Foster},
  journal={Biochemical and biophysical research communications},
  year={1990},
  volume={169 2},
  pages={
          422-9
        }
}
The objective of this work was to investigate the role of leukotrienes in the production of IL-1 by activated human peripheral blood monocytes and mouse peritoneal macrophages. Using overnight adherent macrophages, stimulation with lipopolysaccharide or zymosan caused a time-dependent increase in IL-1 production. LTC4 was detected and preceded IL-1 production only in zymosan-treated macrophages. Lipopolysaccharide did not stimulate macrophages to produce LTC4. Zymosan-stimulated LTC4 production… Expand
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